Mechanical stress connects cortical folding to fiber organization in the developing brain [0.03%]
机械应力连接皮层折叠与发育性大脑纤维组织状态
Kara E Garcia,Christopher D Kroenke,Philip V Bayly
Kara E Garcia
During development of the gyrencephalic brain, both the formation of cortical folds and the establishment of axonal tracts require large, coordinated mechanical deformations. Cortical folding enables a high ratio of cortical surface area to...
Qiyue Zhang,Jingfeng Zhou
Qiyue Zhang
A recent study by González et al. provides causal evidence that the anterior cingulate cortex (ACC) is crucial for rats to maintain persistence in reward-seeking behaviors across both information- and effort-based choice tasks, highlightin...
Pierre Dourlen,Devrim Kilinc,Isabelle Landrieu et al.
Pierre Dourlen et al.
Bridging integrator 1 (BIN1) is a ubiquitously expressed protein that plays a critical role in endocytosis, trafficking and cytoskeletal dynamics. In 2010, BIN1 gene was reported as a major genetic risk factor for Alzheimer's disease (AD), ...
Kami Koldewyn,Hilary Richardson
Kami Koldewyn
In a recent study, Im, Shirahatti, and Isik used voxel-wise encoding modelling to show that cues to social interaction predict brain activity in children aged 3-12 years. Their findings have implications for understanding early social devel...
[11C]ER176 images brain inflammation across TSPO genotypes and colocalizes with tau [0.03%]
[11C]ER176 影像图显示小胶质细胞活化并可与tau蛋白共定位
Aisling M Chaney,Brian A Gordon
Aisling M Chaney
Accurately measuring brain inflammation in Alzheimer's disease (AD) is crucial due to the role of inflammatory processes in neurodegeneration. In a recent study, Appleton, Finn, et al. used [11C]ER176, a novel translocator protein 18 kDa (T...
Baruch Haimson,Adi Mizrahi
Baruch Haimson
Understanding how innate predispositions and learned experiences interact to shape behavior is a central question in systems neuroscience. Traditionally, innate behaviors, that is, those present without prior learning and governed by evolut...
Epigenetic and metabolic regulation of developmental timing in neocortex evolution [0.03%]
新大脑皮层进化中发育时机的表观遗传和代谢调控
Matilde Aquilino,Nora Ditzer,Takashi Namba et al.
Matilde Aquilino et al.
The human brain is characterized by impressive cognitive abilities. The neocortex is the seat of higher cognition, and neocortex expansion is a hallmark of human evolution. While developmental programs are similar in different species, the ...
Spatiotemporal calcium dynamics orchestrate oligodendrocyte development and myelination [0.03%]
空间时间钙动态协调少突胶质细胞的发育和髓鞘形成
Jiaxing Li,Frederic Fiore,Kelly R Monk et al.
Jiaxing Li et al.
Oligodendrocyte lineage cells (OLCs), comprising oligodendrocyte precursor cells (OPCs) and oligodendrocytes, are pivotal in sculpting central nervous system (CNS) architecture and function. OPCs mature into oligodendrocytes, which enwrap a...
Understanding disrupted motivation in Parkinson's disease through a value-based decision-making lens [0.03%]
通过基于价值的决策制定视角来了解帕金森病中受损的动力机制
Campbell Le Heron,Lee-Anne Morris,Sanjay Manohar
Campbell Le Heron
Neurobehavioural disturbances such as loss of motivation have profound effects on the lives of many people living with Parkinson's disease (PD), as well as other brain disorders. The field of decision-making neuroscience, underpinned by a p...
Marc Shenouda,Paul M McKeever,Janice Robertson
Marc Shenouda
In a recent study, Dykstra and colleagues show that shortened TAR DNA Binding Protein 43 (sTDP-43) isoforms are generated as by-products of TDP-43 autoregulation. sTDP-43 levels are regulated through nonsense-mediated decay and proteasomal ...