Gioia De Franceschi,Karl Farrow
Gioia De Franceschi
A recent comparative transcriptomics study by Liu et al. highlights that conserved neuronal identity and synaptic gene expression in the superior colliculus of mice, tree shrews, and humans coexist with species-specific differences in prima...
Aksheev Bhambri,Lu O Sun
Aksheev Bhambri
Myelin formation involves massive lipid production, which requires extensive choline uptake and metabolism. Highlighting two recent studies conducted by Liu et al. and Chen et al., we discuss the identification of Slc44a1 as the primary oli...
David A Vinson,Ian Maze
David A Vinson
Monoaminergic neurotransmission has long been recognized as essential for the development, maintenance, and plasticity of the nervous system, with classical models defining serotonin, dopamine, and histamine as extracellular messengers acti...
Anna Flury,Marie-Kim St-Pierre,Pinar Ayata et al.
Anna Flury et al.
Microglia are the brain's primary innate immune cells, which maintain neural homeostasis through surveillance, debris clearance, and synaptic remodeling. Dark microglia represent a distinct state of microglia that came into recent focus due...
Sarah R Heilbronner,R Clay Reid,Tanya K Casta et al.
Sarah R Heilbronner et al.
The human brain's long-range axonal connections are the scaffolding for communication across functionally distinct areas. Yet knowledge of the human brain's wiring diagram remains limited, largely due to longstanding technological challenge...
Molecular insights into anticonvulsant and botulinum neurotoxin binding of synaptic vesicle glycoprotein 2 [0.03%]
关于突触囊泡糖蛋白2的抗惊厥和肉毒杆菌神经毒素结合作用的分子见解
Richard A Kammerer,Volodymyr M Korkhov
Richard A Kammerer
Synaptic vesicle glycoprotein 2 (SV2) isoforms are crucial for synaptic function and neurotransmission. Although their precise physiological roles remain unclear, SV2 proteins serve as receptors for several botulinum neurotoxins (BoNTs) and...
Chloe A Mickels,Maxwell H Turner
Chloe A Mickels
The visual system can function across variable scene statistics and behavioral contexts. This flexibility arises in part from neural feedback, which shapes visual processing to align with prevailing stimulus conditions and behavioral goals....
Developmental perspectives on spatial navigation: sensory development, experience, and neuronal heterogeneity [0.03%]
空间导航的发展视角：感觉发展、体验和神经元异质性
Xiaojing Chen,Liming Tan,Cheng Wang
Xiaojing Chen
Spatial cognition in mammals relies on various spatially tuned cell types in the hippocampus and associated brain regions. Recent studies have increasingly explored the developmental timelines of these cells, their characteristics during ea...
Jonathan I Spencer,Yulia Sudarikova,Michael J Devine
Jonathan I Spencer
Neurons are highly polarised and compartmentalised cells with organelles that are specialised to support their spatial and functional demands. This includes lysosomes, which are single-membrane-bound organelles enveloping acidic contents en...
Rebecca S Williams,James B Rowe
Rebecca S Williams
Apathy is a common symptom across a wide range of neurodegenerative and psychiatric conditions, characterised by a loss of goal-directed action. It is associated with faster rates of cognitive and functional decline, poor prognosis, and hig...