Mikel L Cawley,Shannon Farris
Mikel L Cawley
Mitochondria are energy- and metabolite-producing organelles that are differentially distributed throughout neuronal axons and dendrites to meet unique energy demands. Emerging evidence indicates that mitochondria in dendrites can be molecu...
John A Lesku,Hannah Elmes
John A Lesku
Sleep is widespread across animal species, yet its functions remain enigmatic. In a recent study, Aguillon, Harduf et al. characterize sleep in two of the simplest neuron-bearing animals to reveal that DNA, damaged while awake, is repaired ...
Splicing, RNA editing, and auxiliary subunits shaped AMPA receptor function through coordinated evolution [0.03%]
通过协调进化，剪接、RNA编辑和辅助亚基塑造了AMPA受体的功能
Derek Bowie
Derek Bowie
Post-transcriptional regulation of AMPA-type ionotropic glutamate receptors (AMPARs) emerged in early vertebrates alongside a major expansion of AMPAR auxiliary subunits. Recent work shows that two key modifications-alternative splicing of ...
Xu Chen,Bokai Zhu
Xu Chen
Nuclear speckles, traditionally considered mainly as reservoirs of splicing factors, are increasingly recognized as dynamic biomolecular condensates essential for RNA metabolism, transcriptional regulation, and chromatin organization. Recen...
A dual-function framework of interoception: the information and coordination modes of interoceptive signaling [0.03%]
内感受的双重功能框架：内感受信号传递的信息模式和协调模式
Catherine Tallon-Baudry,Marie Loescher,Anthony Clément
Catherine Tallon-Baudry
Interoceptive signals inform the brain about physiological parameters, supporting bodily regulation-a process we refer to as the information mode of interoceptive signaling. Based on evidence in cardiac, respiratory, and gastric interocepti...
Phagocytosis and neuroinflammation: orchestrating central nervous system homeostasis, repair, and the resolution of inflammation [0.03%]
吞噬作用与神经炎症：协调中枢神经系统稳态、修复及消炎反应
Andrew D Gaudet,Laura K Fonken
Andrew D Gaudet
The ingestion of foreign material-phagocytosis-is a fundamental feature shared across phyla, from single-celled ameba to more complex mammalian cells. Phagocytosis is a crucial process for maintaining homeostasis in body systems, including ...
Challenges and opportunities in adapting high-throughput functional assays for in vivo neuroscience [0.03%]
高通量功能检测在体内神经科学中的适应挑战与机遇
Din Selmanovic,Joseph D Dougherty
Din Selmanovic
High-throughput functional assays, including CRISPR perturbations with single-cell readouts and massively parallel reporter assays, are redefining studies of gene regulation and function. These assays are effective in homogeneous cultured c...
Kimberly Gagnon,Gustavo Della Flora Nunes,Cristin G Welle et al.
Kimberly Gagnon et al.
Myelin is traditionally viewed as a passive determinant of conduction velocity, yet emerging work suggests a critical role in shaping the precision of spike propagation. In a recent study, Jamann et al. show that myelination enables burst p...
CHCHD2 links mitochondrial dysfunction and α-synuclein misfolding in Parkinson's disease [0.03%]
CHCHD2基因通过线粒体功能障碍和α-突触核蛋白错误折叠与帕金森病相关联
Derek Narendra,Brent J Ryan
Derek Narendra
Parkinson's disease comprises multiple biological subtypes and a heterogeneous clinical course. A recent study by Liao et al. identifies CHCHD2 mutations as a mitochondrial entry point that links metabolic dysfunction to α-synuclein pathol...
Chunhao Qu,Xiao Yu
Chunhao Qu
In a recent study, Darmohray et al. identified a brainstem pathway underlying sickness-induced sleep in mice. The authors demonstrated that immune-activated circuits in the nucleus of the solitary tract suppress wake-promoting norepinephrin...