Sybren Van Hoornweder,Charlotte J Stagg,Miles Wischnewski
Sybren Van Hoornweder
Transcranial electrical stimulation (tES) encompasses non-invasive neuromodulation techniques, such as transcranial direct and alternating current stimulation, which modulate the central nervous system to probe causal links between the brai...
The production and functions of caudal ganglionic eminence-derived inhibitory neurons [0.03%]
尾部ganglioniceminence衍生的抑制性神经元的产生和功能
Emma Horton,Mercedes F Paredes
Emma Horton
In the brain, maintaining the appropriate levels of excitation and inhibition is required for proper cognitive function. Inhibitory neurons, essential for maintaining this balance and implicated in various neurodevelopmental diseases, are g...
Justine Y Hansen,Bratislav Misic
Justine Y Hansen
Tangled molecular, cellular, and dynamic undercurrents shape brain organization. An emerging paradigm across neuroscience domains is to comprehensively measure the spatial patterning of multiple biological features, yielding precise brain m...
Martin W Hetzer,Tomohisa Toda
Martin W Hetzer
In long-lived mammals, including humans, brain cell homeostasis is critical for maintaining brain function throughout life. Most neurons are generated during development and must maintain their cellular identity and plasticity to preserve b...
Reconstructing Alzheimer's disease one cell type at a time using in vitro tricultures [0.03%]
利用体外三培养体系一次一细胞类型地重建阿尔茨海默病
Tatiana A Giovannucci,Charles Arber,Selina Wray
Tatiana A Giovannucci
In a recent study, Lish and colleagues used a fully human-based, induced pluripotent stem cell (iPSC)-derived triculture model of neurons, astrocytes, and microglia to delineate non-cell autonomous contributions to familial Alzheimer's dise...
Shifting ensembles in visual cortex: context-dependent encoding of learned cues [0.03%]
视皮层中的动态图系：习得性线索的上下文相关编码
Sarah Ruediger
Sarah Ruediger
In a recent study in mice, Faulkner and colleagues revealed that visual cortex representations of learned cues rapidly shifted with a change in the external context. This work highlights the flexible recruitment of distinct neuronal ensembl...
Xin Huang,Ben J Gu
Xin Huang
Recent studies report reduced dementia risk following shingles vaccination, suggesting that varicella-zoster virus (VZV) latency contributes to neuroimmune vulnerability. We propose that subclinical VZV reactivation acts as a renewable peri...
Ilayda Demir,Seung-Hee Lee
Ilayda Demir
Cross-modal generalization enables animals to adapt to changing environments. In a recent paper, Guyoton, Matteucci, et al. demonstrated that a dorsal cortical region enables visuo-tactile generalization by constructing peri-personal space ...
Wookbong Kwon,Michael R Williamson,Benjamin Deneen
Wookbong Kwon
Astrocytes are glial cells of the central nervous system (CNS) that perform an array of diverse functions that are essential for brain activity. Studies on the functional diversity of astrocytes suggest that such diversity may be derived fr...
Triet P M Nguyen,Francesca Alves,Darius J R Lane et al.
Triet P M Nguyen et al.
Neuronal death is a defining feature of neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), multiple sclerosis (MS), and motor neuron diseases, and is accordingly a priority drug target. Among the various ...