Calum K Bonthron,Claire S Durrant
Calum K Bonthron
Oligomeric tau has been increasingly implicated in synaptic impairments observed in Alzheimer's disease. In a recent study, Pareja-Navarro and colleagues provide insights into the precise timeline of synaptic deficits induced by oligomeric ...
Serotonergic and glutamatergic mechanisms converge in ketamine's rapid responses [0.03%]
-serotonin能机制和谷氨酸能机制在氯胺酮的快速作用中交汇-
Manoela V Fogaça
Manoela V Fogaça
Ketamine's rapid antidepressant actions are commonly attributed to glutamatergic mechanisms. In a recent study, Luo and colleagues have shown that ketamine inhibits the serotonin transporter and that prefrontal serotonergic signaling synerg...
From maternal metabolism to offspring brain: how high-fructose diets shape neurodevelopment [0.03%]
从母体代谢到后代大脑：高果糖饮食如何影响神经发育
Ana S Vallés,Facundo H Prado Spalm,Marié L Cuervo Sánchez
Ana S Vallés
Many women of childbearing age regularly consume fructose-rich processed foods, which can disrupt metabolism and trigger a low-grade systemic inflammatory state often overlooked in prenatal check-ups. In this review, we synthesize evidence ...
Cellular and molecular mechanisms of astrocyte plasticity in learning and memory [0.03%]
胶质细胞在学习和记忆中的细胞和分子机制研究
Leanne M Holt,Eric J Nestler,Michelle L Olsen
Leanne M Holt
Learning and memory arise from coordinated activity-dependent plasticity across neural circuits and brain regions. Astrocytes are increasingly recognized as active contributors to learning and memory via their roles in sensing, integrating,...
Maria Alfonso-Triguero,Amaia M Arranz
Maria Alfonso-Triguero
Alzheimer's disease typically unfolds within an aging brain, where astrocytic transcriptional programs are extensively remodeled. A recent study by Choi and colleagues shows that reinstating an aging-dependent Sox9-MEGF10 axis restores amyl...
Nardos Kebede,Steven A Sloan
Nardos Kebede
Cortical development is a tightly coordinated process driven by the self-renewal and differentiation of neural progenitors. Radial glia, the primary neuroectodermal progenitors of the cortex, generate diverse cortical cell types, in part th...
Aging brain, brittle bone [0.03%]
老化大脑与脆弱骨骼
Manyu Zhu,Aaron W James
Manyu Zhu
Accumulating evidence suggests that neurons are key regulators of skeletal tissues. A recent study by Chen et al. demonstrated that aged brain neurons export WD repeat and FYVE domain containing 1 (WDFY1) to bone via extracellular vesicles....
Triggered minds: key considerations for symptom provocation research in anxiety-related disorders [0.03%]
激发心灵：焦虑相关障碍症状诱发研究的关键考虑因素
Xena Serifova,Bart Boets,Laura Luyten
Xena Serifova
Anxiety-related disorders are prevalent and can severely impact daily functioning, making the study of their underlying mechanisms a priority. Symptom provocation is an experimental approach enabling researchers to elicit and examine specif...
The subiculum: cell-type-specific composition, computation, and function [0.03%]
鞍状体：细胞类型特异性组成、计算和功能
Adrienne I Kinman,Larissa Kraus,Mark S Cembrowski
Adrienne I Kinman
The hippocampus is a key brain region for understanding the neurobiological mechanisms of learning, memory, and cognition. The subiculum, which provides the predominant form of hippocampal output via excitatory neurons, offers an advantageo...
Cell-autonomous and noncell-autonomous drivers of dopamine neuron vulnerability in Parkinson's disease [0.03%]
帕金森病中多巴胺能神经元脆弱性的细胞自主和非细胞自主驱动因素
Alex Tchung,Amandine Even,Louis-Éric Trudeau
Alex Tchung
The motor symptoms of Parkinson's disease are linked to age-dependent degeneration of dopamine neurons. Traditionally, the loss of these neurons has been thought to stem mainly from cell-autonomous cellular dysfunctions. However, there is g...