Harnessing neuronal plasticity for sustained symptom relief with DBS [0.03%]
利用深部脑刺激(DBS)的神经可塑性实现持续的症状缓解
Doris D Wang,Coralie de Hemptinne
Doris D Wang
In a recent study, Spencer and colleagues demonstrated that high-frequency microsimulation of the globus pallidus internus (GPi) in individuals with Parkinson's disease induces long-term potentiation (LTP)-like effects in the inhibitory pat...
How do ramping dynamics influence computations in the entorhinal cortex? [0.03%]
放电速率的动态变化对内侧颞叶皮层计算过程的影响是什么？
Matthew F Nolan
Matthew F Nolan
The entorhinal cortex is crucial for declarative memory and spatial cognition. Recent experiments reveal that many entorhinal neurons represent information through ramping activity in which their firing rate changes monotonically between be...
Brain-body states as a link between cardiovascular and mental health [0.03%]
脑-身状态作为心血管健康和精神健康之间联系的纽带
Arno Villringer,Vadim V Nikulin,Michael Gaebler
Arno Villringer
Numerous studies in humans have demonstrated a strong link between heart and brain function at different timescales. We conceptualize this functional coupling using different dimensions of brain-body states, formed through the integration o...
Sensory signals for nausea [0.03%]
与恶心相关的感官信号
Shiling Hu,Ashley Loureiro,Chuchu Zhang
Shiling Hu
Nausea serves as a protective response against harmful ingested stimuli but can also be experienced as a discomforting aspect of various conditions. Recent insights have emerged regarding neural pathways and molecular mechanisms linked to t...
Edwin S Dalmaijer
Edwin S Dalmaijer
In common parlance, 'being in touch with your body' is often used positively. However, in a recent study, Banellis, Rebollo, and colleagues show that better stomach-brain synchronisation is actually associated with increased anxiety and dep...
The integrated stress response in the brain: cell type-specific functions in health and neurological disorders [0.03%]
大脑中的综合应激反应：健康和神经性疾病中特定细胞类型的特异性功能
David Ho-Tieng,Vijendra Sharma,Nahum Sonenberg et al.
David Ho-Tieng et al.
The integrated stress response (ISR) is an evolutionarily conserved signaling network that regulates protein synthesis in response to diverse cellular stressors to promote stress adaptation. The ISR also responds to physiological stimuli to...
Retrotrapezoid nucleus chemoreception: mechanisms of function and contributions to disordered breathing in disease [0.03%]
脑干网状区化学感受器的功能机制及其在疾病时不规则呼吸的发病中的作用
Daniel K Mulkey,Thiago S Moreira,Ana C Takakura et al.
Daniel K Mulkey et al.
The brain regulates breathing in response to changes in CO2/H+ by a process referred to as respiratory chemoreception. The retrotrapezoid nucleus (RTN) is essential for this function. RTN neurons are intrinsically activated by CO2/H+. Astro...
The cost of remembering: engram competition as a flexible mechanism of forgetting [0.03%]
记忆的成本：作为灵活遗忘机制的回忆竞争现象
Livia Autore,Michael R Drew,Tomás J Ryan
Livia Autore
The retention and use of long-term memories is crucial for adaptive behavior. While stable memories help organisms anticipate outcomes, they may become maladaptive if not updated to reflect new conditions as the environment changes. Accumul...
Induction of plasticity and metaplasticity using noninvasive brain stimulation [0.03%]
运用非侵入式脑刺激诱导可塑性和元可塑性
Amitabh Bhattacharya,Ghazaleh Darmani,Kaviraja Udupa et al.
Amitabh Bhattacharya et al.
Noninvasive brain stimulation (NIBS) methods can modulate brain plasticity, the fundamental process by which synaptic connections are strengthened or weakened in response to synaptic activity or external stimuli. This review synthesizes cur...
Copine-6 as a regulator of TRPM3 membrane trafficking and noxious heat sensation [0.03%]
Copine-6在TRPM3膜转运和有害热感方面的作用机制研究
Chen Zhang,Qingjian Han
Chen Zhang
Noxious heat sensation involves multiple molecular receptors that operate under complex regulatory mechanisms. In a recent study, Gao, Yan, and colleagues identified Copine-6 as a calcium-sensitive phospholipid-binding protein that promotes...