Transformation, again? Impact of a second pregnancy on the brain, cognition, and sense of self [0.03%]
再次改变？第二次怀孕对大脑、认知和自我意识的影响
Kelsey Perrykkad,M Navyaan Siddiqui,Sharna Jamadar
Kelsey Perrykkad
Becoming a mother for the first time is a transformative experience, resulting in widespread changes in systemic physiology, neurobiology, cognition, and the sense of self. In a recent study, Straathof et al. demonstrated that a second preg...
Neuronal STAT1 as a phase switch from antiviral defense to synaptopathy in encephalitis [0.03%]
神经元STAT1作为脑炎中从抗病毒防御到突触病变的相变开关
Giovanni Di Liberto,Doron Merkler
Giovanni Di Liberto
Interferon signaling is essential for antiviral defense in the central nervous system, yet sustained neuronal STAT1 phosphorylation (pSTAT1) can promote immune-mediated synaptic and network injury. In this opinion article, we argue that neu...
EEG microstates: from methodological foundations to clinical translation [0.03%]
脑电微状态：从方法论基础到临床转化研究
Christoph M Michel,Lucie Bréchet
Christoph M Michel
Electroencephalography (EEG) microstates represent discrete topographic configurations persisting approximately 50-120 ms before transitioning to new patterns. These transient states provide unique insights into large-scale brain organizati...
Mapping neuronal selectivity and invariance in the mammalian visual cortex using digital twins [0.03%]
使用数字孪生映射哺乳动物视觉皮层中的神经元选择性和不变性
Xiaoxuan Jia
Xiaoxuan Jia
In a recent study, Ding, Tran, and colleagues applied model-guided closed-loop physiology to systematically map neuronal selectivity and invariance in the mouse primary visual cortex, revealing a spectrum of receptive-field invariances, inc...
Hongyun Wang,Shuhan Liu,Ling Bai
Hongyun Wang
The vagus nerve, among its various functions, carries gut nutrient signals to brain reward circuits. In a recent study, Onimus and colleagues have shown it is more than a simple relay: vagal integrity is required for maintaining dopamine re...
Marcel E Sayre,Ajay Narendra,Stanley Heinze et al.
Marcel E Sayre et al.
Spatial representations are a fundamental aspect of cognition. It remains largely unknown when and why the capacity to neurally represent space first evolved. In this opinion article, we argue that a strong candidate for the earliest such r...
Christy Hung
Christy Hung
In a recent study, Sauvé et al. identified hypothalamic tanycytes as a route for tau transport from cerebrospinal fluid to blood and suggested that disruption of this pathway contributes to Alzheimer's disease pathology. The work broadens ...
Epigenetic biomarkers in neurodegenerative diseases: from molecular signatures to therapeutic targets [0.03%]
表观遗传生物标志物在神经退行性疾病中的研究：从分子特征到治疗靶点
Sam J Washer,Marty Frith,Elizabeth Cowan et al.
Sam J Washer et al.
Collectively, neurodegenerative diseases impose an escalating global health burden, representing one of the leading causes of death and disability worldwide. Despite their growing prevalence, diagnosis and treatment remain major challenges,...
Regulation and function of interstitial axon branching in cortical projection neurons [0.03%]
皮质投射神经元间质轴突分支的调控及其功能
Jakub Ziak,Sriram Sudarsanam,Alex L Kolodkin
Jakub Ziak
Nervous system function is contingent on accurate neuronal connectivity patterns. A single neuron must often connect with multiple synaptic partners. Excitatory cortical projection neurons in the mammalian brain are a prime example of neuro...
Cognitive performance after stroke at a young age from a brain network perspective [0.03%]
从脑网络角度探究年轻卒中患者的认知功能损伤特点
Hao Li,Mijntje M I Schellekens,Vitória Piai et al.
Hao Li et al.
Cognitive impairment is present in nearly half of young stroke survivors, with about one-quarter suffering from aphasia. Recent studies have explored trajectories of cognitive functioning beyond the acute phase after stroke, the potential m...