Neuronal encoding of behaviors and instrumental learning in the dorsal striatum [0.03%]
背侧纹状体中行为和操作式学习的神经元编码
Christophe Varin,Alban de Kerchove d&#x;Exaerde
Christophe Varin
The dorsal striatum is instrumental in regulating motor control and goal-directed behaviors. The classical description of the two output pathways of the dorsal striatum highlights their antagonistic control over actions. However, recent exp...
Kimberly L McArthur
Kimberly L McArthur
A recent study by Kaneko and colleagues provides evidence that developing cranial motor neurons in larval zebrafish refine their input specificity over time, using an activity-dependent mechanism that may depend, in part, on adaptive dendri...
Advancing ALS research: public-private partnerships to accelerate drug and biomarker development [0.03%]
ALS研究的进展：加速药物和生物标志物开发的公私合作伙伴关系
Alessio Travaglia,Shubhangi Lal,Sri Ramulu Pullagura
Alessio Travaglia
Developing effective treatments for amyotrophic lateral sclerosis (ALS) has been hindered by both the complexity of the disease and decentralized research efforts. By fostering collaboration, standardization, and inclusivity, the Accelerati...
The intertwined relationship between circadian dysfunction and Parkinson's disease [0.03%]
昼夜节律紊乱和帕金森病之间的相互关系
Lou C Duret,Emi Nagoshi
Lou C Duret
Neurodegenerative disorders represent a leading cause of disability among the elderly population, and Parkinson's disease (PD) is the second most prevalent. Emerging evidence suggests a frequent co-occurrence of circadian disruption and PD....
Yongling Lin,Marco K Wittmann
Yongling Lin
The success of our actions often depends on what others are doing. How does the brain discern predictions of others' actions when situations are ambiguous? Recent work by Ma and colleagues suggests that the brain solves this problem by ente...
Representational spaces in orbitofrontal and ventromedial prefrontal cortex: task states, values, and beyond [0.03%]
皮层轨道前区和腹内侧前额叶的感觉表示、任务状态及价值计算
Nir Moneta,Shany Grossman,Nicolas W Schuck
Nir Moneta
The orbitofrontal cortex (OFC) and ventromedial-prefrontal cortex (vmPFC) play a key role in decision-making and encode task states in addition to expected value. We review evidence suggesting a connection between value and state representa...
Jennifer Isaac,Malavika Murugan
Jennifer Isaac
Across species, social behaviors are shaped and maintained through positive reinforcement of affiliative social interactions. As with nonsocial rewards, the reinforcing properties of social interactions have been shown to involve interplay ...
Jordan M Ross,Jordan P Hamm
Jordan M Ross
Cortical responses to stimuli vary dependingon context and expectation. Adding insight into this process, Furutachi et al. recently demonstrated that higher-order thalamic input to visual cortex cooperates with interneurons to augment respo...
Rianne R Campbell,Mary Kay Lobo
Rianne R Campbell
Understanding the neural mechanisms that control addiction processes, including drug-seeking and relapse, is key to finding new targets for substance use disorder (SUD) pharmacotherapies and circuit-based therapies. Addictive drugs alter ac...
Alison D Do,Coline Portet,Romain Goutagny et al.
Alison D Do et al.
Cortical activity is constantly fluctuating between distinct spatiotemporal activity patterns denoted by changes in brain state. States of cortical desynchronization arise during motor generation, increased attention, and high cognitive loa...