Justine Y Hansen,Bratislav Misic
Justine Y Hansen
Tangled molecular, cellular, and dynamic undercurrents shape brain organization. An emerging paradigm across neuroscience domains is to comprehensively measure the spatial patterning of multiple biological features, yielding precise brain m...
Martin W Hetzer,Tomohisa Toda
Martin W Hetzer
In long-lived mammals, including humans, brain cell homeostasis is critical for maintaining brain function throughout life. Most neurons are generated during development and must maintain their cellular identity and plasticity to preserve b...
Reconstructing Alzheimer's disease one cell type at a time using in vitro tricultures [0.03%]
利用体外三培养体系一次一细胞类型地重建阿尔茨海默病
Tatiana A Giovannucci,Charles Arber,Selina Wray
Tatiana A Giovannucci
In a recent study, Lish and colleagues used a fully human-based, induced pluripotent stem cell (iPSC)-derived triculture model of neurons, astrocytes, and microglia to delineate non-cell autonomous contributions to familial Alzheimer's dise...
Shifting ensembles in visual cortex: context-dependent encoding of learned cues [0.03%]
视皮层中的动态图系：习得性线索的上下文相关编码
Sarah Ruediger
Sarah Ruediger
In a recent study in mice, Faulkner and colleagues revealed that visual cortex representations of learned cues rapidly shifted with a change in the external context. This work highlights the flexible recruitment of distinct neuronal ensembl...
Xin Huang,Ben J Gu
Xin Huang
Recent studies report reduced dementia risk following shingles vaccination, suggesting that varicella-zoster virus (VZV) latency contributes to neuroimmune vulnerability. We propose that subclinical VZV reactivation acts as a renewable peri...
Ilayda Demir,Seung-Hee Lee
Ilayda Demir
Cross-modal generalization enables animals to adapt to changing environments. In a recent paper, Guyoton, Matteucci, et al. demonstrated that a dorsal cortical region enables visuo-tactile generalization by constructing peri-personal space ...
Wookbong Kwon,Michael R Williamson,Benjamin Deneen
Wookbong Kwon
Astrocytes are glial cells of the central nervous system (CNS) that perform an array of diverse functions that are essential for brain activity. Studies on the functional diversity of astrocytes suggest that such diversity may be derived fr...
Triet P M Nguyen,Francesca Alves,Darius J R Lane et al.
Triet P M Nguyen et al.
Neuronal death is a defining feature of neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), multiple sclerosis (MS), and motor neuron diseases, and is accordingly a priority drug target. Among the various ...
Urszula Skupio,Alexander Z Harris,Abigail M Polter
Urszula Skupio
Stress has profound impacts on the ventral tegmental area (VTA). However, the complex and opposing effects of stress on the VTA have limited our ability to reach a clear understanding of how adaptation of the VTA can drive behavior followin...
The role of efferocytosis in ischemic stroke and insights from retinopathy [0.03%]
efferocytosis在缺血性脑卒中和视网膜病变中的作用及启示
Carol A Morris,Mohamed A Sadek,Pooja Modi et al.
Carol A Morris et al.
Efferocytosis, the phagocytic removal of dead cells by microglia and macrophages, was recently recognized as a critical process in the resolution of inflammation and tissue repair following ischemic stroke. In this review, we examine the pa...