Raouf A Khalil
Raouf A Khalil
Juanjuan Chen,Raouf A Khalil
Juanjuan Chen
Normal pregnancy is associated with marked hemodynamic and uterine changes that allow adequate uteroplacental blood flow and uterine expansion for the growing fetus. These pregnancy-associated changes involve significant uteroplacental and ...
Regulation of Matrix Metalloproteinase in the Pathogenesis of Diabetic Retinopathy [0.03%]
糖尿病视网膜病变发病机制中的基质金属蛋白酶及其调节因子研究进展
Renu A Kowluru,Manish Mishra
Renu A Kowluru
Diabetic retinopathy, a progressive disease, is the major cause of acquired blindness in the developed countries. Despite cutting-edge research in the field, the exact mechanism of this multifactorial disease remains elusive. Matrix metallo...
Matrix Metalloproteinase Inhibitors as Investigational and Therapeutic Tools in Unrestrained Tissue Remodeling and Pathological Disorders [0.03%]
基质金属蛋白酶抑制剂在不受限制的组织重塑和病理障碍中的研究和治疗工具作用机制及应用进展
Jie Liu,Raouf A Khalil
Jie Liu
Matrix metalloproteinases (MMPs) are zinc-dependent proteolytic enzymes that degrade various proteins in the extracellular matrix (ECM). MMPs may also regulate the activity of membrane receptors and postreceptor signaling mechanisms and the...
Anna M Knapinska,Christie-Anne Estrada,Gregg B Fields
Anna M Knapinska
Matrix metalloproteinases (MMPs) have long been implicated for roles in cancer initiation, tumor growth, and metastasis. However, pancreatic cancer clinical trials using broad-based MMP inhibitors were discouraging. To better evaluate the u...
Metalloproteinases in Rheumatoid Arthritis: Potential Therapeutic Targets to Improve Current Therapies [0.03%]
金属蛋白酶与类风湿关节炎：潜在的治疗靶标以改善现有疗法
Yoshifumi Itoh
Yoshifumi Itoh
Rheumatoid arthritis (RA) is a systemic inflammatory disease characterized by the destruction of joint tissues including cartilage and bone. Cartilage degradation is attributed to metalloproteinases (MPs) that belong to matrix metalloprotei...
Matrix Metalloproteinases in Kidney Disease: Role in Pathogenesis and Potential as a Therapeutic Target [0.03%]
肾脏疾病中的基质金属蛋白酶：在发病机制中的作用及作为治疗靶点的潜力
Alan R Parrish
Alan R Parrish
Matrix metalloproteinases (MMPs) are large family of proteinases. In addition to a fundamental role in the remodeling of the extracellular matrix, they also cleave a number of cell surface proteins and are involved in multiple cellular proc...
Charles J Malemud
Charles J Malemud
Matrix metalloproteinases (MMPs) are zinc-dependent enzymes. These enzymes play a critical role in the destruction of articular cartilage in rheumatoid arthritis (RA), osteoarthritis (OA), psoriatic arthritis (PsA), and the spondyloarthropa...
Katiucia B S Paiva,José M Granjeiro
Katiucia B S Paiva
Matrix metalloproteinases (MMPs) are the major protease family responsible for the cleavage of the matrisome (global composition of the extracellular matrix (ECM) proteome) and proteins unrelated to the ECM, generating bioactive molecules. ...
Matrix Metalloproteinases, Neural Extracellular Matrix, and Central Nervous System Pathology [0.03%]
基质金属蛋白酶、神经细胞外基质和中枢神经系统病理学
Ciro De Luca,Michele Papa
Ciro De Luca
The functionality and stability of the central nervous system (CNS) pabulum, called neural extracellular matrix (nECM), is paramount for the maintenance of a healthy network. The loosening or the damage of the scaffold disrupts synaptic tra...