Neil A Mabbott
Neil A Mabbott
Many natural prion diseases are acquired peripherally, such as following the oral consumption of contaminated food or pasture. After peripheral exposure many prion isolates initially accumulate to high levels within the host's secondary lym...
Alba Marín-Moreno,Natalia Fernández-Borges,Juan C Espinosa et al.
Alba Marín-Moreno et al.
Transmissible spongiform encephalopathies (TSEs) are a group of progressive, invariably fatal diseases that affect the nervous system of many mammals including humans. The key molecular event in the pathogenesis of TSEs is the conversion of...
Abigail B Diack,James D Alibhai,Jean C Manson
Abigail B Diack
The production of transgenic mice expressing different forms of the prion protein (PrP) or devoid of PrP has enabled researchers to study the role of PrP in the infectious process of a prion disease and its normal function in the healthy in...
Giuseppe Legname,Fabio Moda
Giuseppe Legname
Transmissible spongiform encephalopathies or prion diseases are a group of fatal neurodegenerative diseases caused by unconventional infectious agents, known as prions (PrPSc). Prions derive from a conformational conversion of the normally ...
Prion Protein and Genetic Susceptibility to Diseases Caused by Its Misfolding [0.03%]
朊蛋白与由其错误折叠引起的疾病遗传易感性的关系
George A Carlson
George A Carlson
Early genetic studies on scrapie, an infectious neurodegenerative disease of sheep that was adapted to mice, provided evidence in support of the hypothesis that the agent was a slow virus with a nucleic acid genome independent of the host. ...
Giulia Rossetti,Paolo Carloni
Giulia Rossetti
Prion diseases, or transmissible spongiform encephalopathies, are a group of rare fatal neurodegenerative maladies that affect humans and animals. The main event in disease progression is the posttranslational conversion of the ubiquitously...
Théo Z Hirsch,Séverine Martin-Lannerée,Sophie Mouillet-Richard
Théo Z Hirsch
Although initially disregarded compared to prion pathogenesis, the functions exerted by the cellular prion protein PrPC have gained much interest over the past two decades. Research aiming at unraveling PrPC functions started to intensify w...
Donald P Weeks,Bing Yang
Donald P Weeks
Yuriko Osakabe,Keishi Osakabe
Yuriko Osakabe
Targeted modification of specific genes via genome editing is now used routinely to modify plant genomes. In developing new mutations in plant genomes using the widely used CRISPR/Cas9 system, it is important for further use in plant molecu...
Honghao Bi,Bing Yang
Honghao Bi
Engineered, site-specific nucleases induce genomic double-strand DNA breaks and break repair processes enable genome editing in a plethora of eukaryotic genomes. TALENs (transcription activator-like effector nucleases) and CRISPR/Cas (clust...