Experimental Therapy of Advanced Breast Cancer: Targeting NFAT1-MDM2-p53 Pathway [0.03%]
乳腺癌实验疗法：靶向NFAT1-MDM2-p53通路
Jiang-Jiang Qin,Wei Wang,Ruiwen Zhang
Jiang-Jiang Qin
Advanced breast cancer, especially advanced triple-negative breast cancer, is typically more aggressive and more difficult to treat than other breast cancer phenotypes. There is currently no curable option for breast cancer patients with ad...
Therapeutic Use of Estrogen Receptor β Agonists in Prevention and Treatment of Endocrine Therapy Resistant Breast Cancers: Observations From Preclinical Models [0.03%]
雌激素受体β激动剂在防治内分泌治疗抵抗性乳腺癌中的应用及基础研究发现
Kumaraguruparan Ramasamy,Cathy Samayoa,Naveen Krishnegowda et al.
Kumaraguruparan Ramasamy et al.
Breast cancer is one of the most common cancers in the world. The majority of breast cancers express estrogen receptor (ER)α, and endocrine therapy is the primary therapeutic approach to treat ER positive breast cancers. However, developin...
Sushmita Bose Nandy,Rajkumar Lakshmanaswamy
Sushmita Bose Nandy
Decades of cancer research have led to substantial progress in the treatment of primary breast cancers. Despite of the advancement in this field, treating a metastatic disease has remained a mammoth task. One of the possible theories explai...
Association of Cytokines and Chemokines in Pathogenesis of Breast Cancer [0.03%]
细胞因子和化学因子在乳腺癌发病机制中的关联性研究
Jeronay King,Hina Mir,Shailesh Singh
Jeronay King
Breast cancer touches women's life worldwide. Expected outcome is not achieved due to molecular heterogeneity and complex biology despite substantial advancement in diagnosis, prevention and treatment of breast cancer. Patients with estroge...
Stella Winters,Charmaine Martin,Daniel Murphy et al.
Stella Winters et al.
Globally, breast cancer is both the most commonly occurring cancer and the commonest cause of cancer death among women. Available data suggest that incidence and mortality in high-resource countries has been declining whereas incidence and ...
Giuseppe Legname,Silvia Vanni
Giuseppe Legname
Understanding the Effect of Disease-Related Mutations on Human Prion Protein Structure: Insights From NMR Spectroscopy [0.03%]
基于核磁共振光谱的人类朊蛋白结构研究及与疾病相关的突变的影响分析
Ivana Biljan,Gregor Ilc,Janez Plavec
Ivana Biljan
Prion diseases or transmissible spongiform encephalopathies constitute a group of fatal neurodegenerative diseases that can be of sporadic, genetic, or acquired origin. The central molecular event of prion diseases is the conformational con...
Daniela Sarnataro,Anna Pepe,Chiara Zurzolo
Daniela Sarnataro
Cellular prion protein (PrPC) is a mammalian glycoprotein which is usually found anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor. The precise function of PrPC remains elusive but may depend upon its cellular ...
Biosafety of Prions [0.03%]
朊病毒的生物安全问题
Edoardo Bistaffa,Martina Rossi,Chiara M G De Luca et al.
Edoardo Bistaffa et al.
Prions are the infectious agents that cause devastating and untreatable disorders known as Transmissible Spongiform Encephalopathies (TSEs). The pathologic events and the infectious nature of these transmissible agents are not completely un...
Annachiara Gandini,Maria Laura Bolognesi
Annachiara Gandini
Therapy of prion diseases represents an extremely challenging effort for scientists working in the field. These challenges are epitomized by 20 years of failures in clinical trials and preclinical investigations. However, the discovery that...