Caroline M Alexander
Caroline M Alexander
Attention has been focused on Wnt signaling in the mouse mammary gland for several decades, firstly by the discovery of several Wnt loci among the oncogenes revealed by MMTV-based insertional mutagenesis screening of mouse mammary gland, an...
Li-Shu Zhang,Lawrence Lum
Li-Shu Zhang
Genetically based observations stemming from defects in development and in regeneration form the foundation of our understanding regarding how the secreted WNT proteins control coordinated cell fate decision-making in adult tissues. At the ...
Si Hui Tan,Nick Barker
Si Hui Tan
Wnt/β-catenin signaling is integral to the homeostasis and regeneration of many epithelial tissues due to its critical role in adult stem cell regulation. It is also implicated in many epithelial cancers, with mutations in core pathway com...
Wnt Signaling in Stem Cells and Cancer Stem Cells: A Tale of Two Coactivators [0.03%]
WNT信号通路在干细胞和癌细胞中的作用：两种共激活因子的故事
Michael Kahn
Michael Kahn
Wnt signaling in stem cells plays critical roles in development, normal adult physiology, and disease. In this chapter, we focus on the role of the Wnt signaling pathway in somatic stem cell biology and its critical role in normal tissue ho...
Yongping Wang,Chengji J Zhou,Youhua Liu
Yongping Wang
Wnt signal cascade is an evolutionarily conserved, developmental pathway that regulates embryogenesis, injury repair, and pathogenesis of human diseases. It is well established that Wnt ligands transmit their signal via canonical, β-cateni...
Francesco Girardi,Fabien Le Grand
Francesco Girardi
Wnt is a family of signaling molecules involved in embryogenesis, adult tissue repair, and cancer. They activate canonical and noncanonical Wnt signaling cascades in target cells. Several studies, within the last decades, showed that severa...
Of Wnts and Ribosomes [0.03%]
从Wnt到核糖体
Astrid S Pfister,Michael Kühl
Astrid S Pfister
Wnt proteins are secreted glycoproteins that activate different intracellular signal transduction pathways. They regulate cell proliferation and are required for proper embryonic development. Misregulation of Wnt signaling can result in var...
Wnt Ligands as a Part of the Stem Cell Niche in the Intestine and the Liver [0.03%]
肠和肝干细胞生态位中的Wnt配体
Bahar Degirmenci,George Hausmann,Tomas Valenta et al.
Bahar Degirmenci et al.
The term "Wnt signaling" does not refer to one uniform signal transduction cascade. Instead, it describes the multiple discrete signals elicited by Wnt ligands following their interaction with distinct receptor complexes. The interaction of...
Ellen Shrock,Marc Güell
Ellen Shrock
CRISPR-Cas9 has revolutionized the generation of transgenic animals. This system has demonstrated an unprecedented efficiency, multiplexability, and ease of use, thereby reducing the time and cost required for genome editing and enabling th...
Takuro Horii,Izuho Hatada
Takuro Horii
Haploidy is a useful feature for the study of gene function because disruption of one allele in haploid cells, which contain only a single set of chromosomes, can cause loss-of-function phenotypes. Recent success in generating haploid embry...