Weiping Zheng
Weiping Zheng
Ning Zhang,Anthony A Sauve
Ning Zhang
NAD+ acts as a crucial regulator of cell physiology and as an integral participant in cellular metabolism. By virtue of a variety of signaling activities this central metabolite can exert profound effects on organism health status. Thus, wh...
Nima Rajabi,Iacopo Galleano,Andreas S Madsen et al.
Nima Rajabi et al.
Lysine residues across the proteome are modified by posttranslational modifications (PTMs) that significantly enhance the structural and functional diversity of proteins. For lysine, the most abundant PTM is ɛ-N-acetyllysine (Kac), which p...
Shengchao Li,Weiping Zheng
Shengchao Li
Sirtuins are a family of intracellular enzymes whose enzymatic activities include catalyzing the β-nicotinamide adenine dinucleotide (β-NAD+)-dependent Nɛ-acyl-lysine deacylation and the β-NAD+-dependent mono-ADP-ribosylation. Among the...
Sin Hui Neo,Bor Luen Tang
Sin Hui Neo
Sirtuins and their pharmacological activators/inhibitors have been associated with a range of neuroprotective effects or disease modifying influences in neurological disorders. Huntington's disease (HD) is an autosomal-dominant, progressive...
Xiao Hu,Weiping Zheng
Xiao Hu
Sirtuins refer to a family of intracellular enzymes that are the yeast silent information regulator 2 (sir2) protein homologs found in organisms from all the three kingdoms of life. This family of enzymes primarily catalyze the protein Nɛ-...
Wnt Signaling in the Central Nervous System: New Insights in Health and Disease [0.03%]
中枢神经系统的Wnt信号通路：健康与疾病的新见解
Carolina A Oliva,Carla Montecinos-Oliva,Nibaldo C Inestrosa
Carolina A Oliva
Since its discovery, Wnt signaling has been shown to be one of the most crucial morphogens in development and during the maturation of central nervous system. Its action is relevant during the establishment and maintenance of synaptic struc...
Stephanie Grainger,David Traver,Karl Willert
Stephanie Grainger
Leukemia and lymphoma are a wide encompassing term for a diverse set of blood malignancies that affect people of all ages and result in approximately 23,000 deaths in the United States per year (Siegel RL, Miller KD, Jemal A. Cancer statist...
The Central Role of Wnt Signaling and Organoid Technology in Personalizing Anticancer Therapy [0.03%]
Wnt信号通路和类器官技术在抗癌治疗个体化中的中心作用
Elizabeth Vincan,Renate H M Schwab,Dustin J Flanagan et al.
Elizabeth Vincan et al.
The Wnt pathway is at the heart of organoid technology, which is set to revolutionize the cancer field. We can now predetermine a patient's response to any given anticancer therapy by exposing tumor organoids established from the patient's ...