Taeko Miyagi,Kohta Takahashi,Koji Yamamoto et al.
Taeko Miyagi et al.
Sialidases are glycosidases responsible for the removal of α-glycosidically linked sialic acid residues from carbohydrate portions of glycoproteins and glycolipids, this process being the initial step in the degradation of such glycoconjug...
Roger Sandhoff,Heike Schulze,Konrad Sandhoff
Roger Sandhoff
Gangliosides (GGs) are cell type-specific sialic acid-containing glycosphingolipids (GSLs), which are enriched in mammalian brain. Defects in GSL metabolism cause fatal human diseases. GSLs are composed of a hydrophilic oligosaccharide link...
Cellular Metabolism and Aging [0.03%]
细胞代谢与衰老
Andre Catic
Andre Catic
Metabolic changes are hallmarks of aging and genetic and pharmacologic alterations of relevant pathways can extend life span. In this review, we will outline how cellular biochemistry and energy homeostasis change during aging. We will high...
Dwarf Mice and Aging [0.03%]
侏儒鼠和衰老
Michal M Masternak,Justin Darcy,Berta Victoria et al.
Michal M Masternak et al.
Dwarf mice have been studied for many decades, however, the focus of these studies shifted in 1996 when it was shown by Brown-Borg and her coworkers that Ames dwarf (Prop1df) mice are exceptionally long-lived. Since then, Snell dwarf (Pit1d...
The Necessity of Active Muscle Metabolism for Healthy Aging: Muscular Activity Throughout the Entire Day [0.03%]
主动肌肉代谢对于健康老龄化是必要的：全天候肌肉活动的重要性
Marc T Hamilton,Deborah G Hamilton,Theodore W Zderic
Marc T Hamilton
There is more need for "a movement-movement" than ever before. The percentage of seniors in our population is rising exponentially. Sedentary lifestyles throughout the lifespan have become the norm, including inactive youth and a sedentary ...
The Intersection of Curandismo and Western Medicine and Their Epidemiological Impact for Aging Mexican Americans [0.03%]
库randismo与西方医学的交叉及其对墨西哥美国老年人口的流行病学影响
Pamela Anne Quiroz
Pamela Anne Quiroz
The rising costs of health care in the United States continue to stimulate interest in alternative health care options among Americans. Western medicine is also beginning to pay more attention to these alternative practices and their utilit...
R Alexander Bentley,Corinna N Ross,Michael J O&#x;Brien
R Alexander Bentley
Obesity contributes to the aging process through the alteration of metabolic pathways evidenced biochemically in the relationship between caloric restriction and longevity. Humans have entered into an era of metabolism and aging entirely un...
Metabolic Aspects of Aging [0.03%]
衰老的代谢方面
Yih-Woei Fridell,Felipe Sierra
Yih-Woei Fridell
Metabolic interventions involving undernutrition but not malnutrition (e.g., caloric restriction, CR) are effective strategies for improving both health and longevity in species ranging from lower organisms to nonhuman primates. Initial hum...
A Comparative Approach to Metabolic Aspects of Aging: Conserved Mechanisms and Effects of Calorie Restriction and Environment [0.03%]
衰老代谢方面的比较研究：保守机制及卡路里限制和环境的影响
Mary Ann Ottinger
Mary Ann Ottinger
Metabolic systems and the function of these systems are complex, involving biochemical pathways, endocrine, neuroendocrine systems, and physiological systems and interact with environmental conditions. Studies in animal models have been inv...
Stephen J Spann,Mary Ann Ottinger
Stephen J Spann
In the United States, the average lifespan has increased despite the dramatic increase in obesity, diabetes, and other conditions that worsen during aging. As the longevity of US population increases, it is critical to understand the factor...