Chapter Three - Ubiquitination and Protein Turnover of G-Protein-Coupled Receptor Kinases in GPCR Signaling and Cellular Regulation [0.03%]
第七章：G蛋白偶联受体激酶的泛素化及其在G蛋白偶联受体信号转导和细胞调控中的作用蛋白质周转
P Penela
P Penela
G-protein-coupled receptors (GPCRs) are responsible for regulating a wide variety of physiological processes, and distinct mechanisms for GPCR inactivation exist to guarantee correct receptor functionality. One of the widely used mechanisms...
Chapter Two - Heterotrimeric G Protein Ubiquitination as a Regulator of G Protein Signaling [0.03%]
第二章 非对称G蛋白泛素化调节G蛋白信号转导
M Torres
M Torres
Ubiquitin-mediated regulation of G proteins has been known for over 20 years as a result of discoveries made independently in yeast and vertebrate model systems for pheromone and photoreception, respectively. Since that time, several detail...
Chapter One - Ubiquitination and Deubiquitination of G Protein-Coupled Receptors [0.03%]
第一章 组蛋白及组蛋白去乙酰化在GPCR中的作用机制研究
P-Y Jean-Charles,J C Snyder,S K Shenoy
P-Y Jean-Charles
The seven-transmembrane containing G protein-coupled receptors (GPCRs) constitute the largest family of cell-surface receptors. Transmembrane signaling by GPCRs is fundamental to many aspects of physiology including vision, olfaction, cardi...
Ya-Xiong Tao
Ya-Xiong Tao
Genetics of Adiposity in Large Animal Models for Human Obesity-Studies on Pigs and Dogs [0.03%]
大型动物肥胖模型的人类肥胖症遗传学研究——猪和狗的相关研究
M Stachowiak,I Szczerbal,M Switonski
M Stachowiak
The role of domestic mammals in the development of human biomedical sciences has been widely documented. Among these model species the pig and dog are of special importance. Both are useful for studies on the etiology of human obesity. Geno...
From Genome-Wide Association Study to Phenome-Wide Association Study: New Paradigms in Obesity Research [0.03%]
从全基因组关联研究到全表型组关联研究：肥胖症研究的新范式
Y-P Zhang,Y-Y Zhang,D D Duan
Y-P Zhang
Obesity is a condition in which excess body fat has accumulated over an extent that increases the risk of many chronic diseases. The current clinical classification of obesity is based on measurement of body mass index (BMI), waist-hip rati...
Epigenetics of Obesity [0.03%]
肥胖的表观遗传学
A Lopomo,E Burgio,L Migliore
A Lopomo
Obesity is a metabolic disease, which is becoming an epidemic health problem: it has been recently defined in terms of Global Pandemic. Over the years, the approaches through family, twins and adoption studies led to the identification of s...
W Wang,Y-X Tao
W Wang
Growth hormone secretagogue receptor (GHSR) was originally identified as an orphan receptor in porcine and rat anterior pituitary membranes. In 1999, GHSR was deorphanized and shown to be a receptor for ghrelin, a peptide hormone secreted f...
Z Yang,Y-X Tao
Z Yang
The prevalence of obesity calls for novel therapeutic targets. The melanocortin-3 receptor (MC3R) has been increasingly recognized as an important regulator of energy homeostasis and MC3R has been intensively analyzed in molecular genetic s...
Rare Syndromes and Common Variants of the Brain-Derived Neurotrophic Factor Gene in Human Obesity [0.03%]
人肥胖症中罕见综合症和脑源性神经营养因子基因的常见变异体
J C Han
J C Han
Rare genetic disorders that cause BDNF haploinsufficiency, such as WAGR syndrome, 11p deletion, and 11p inversion, serve as models for understanding the role of BDNF in human energy balance and neurocognition. Patients with BDNF haploinsuff...