Analysis of low-input and degraded forensic DNA trace samples with NGS using the MiSeq FGx platform [0.03%]
利用MiSeq FGx平台使用NGS分析低起始量和退化的法医DNA检材
Amel Larnane,Cédric Fund,Mélanie Letexier et al.
Amel Larnane et al.
This study addresses the challenge of profiling low-input and degraded DNA traces in forensic science, by evaluating the ForenSeq™ DNA Signature Prep Kit on the MiSeq FGx platform. The standard microsatellite-based genotyping technology us...
Lourdes Prieto,Walther Parson
Lourdes Prieto
The next frontier in forensic genetics: Single-cell genetic analysis and its expanding role [0.03%]
forensics基因组学的下一个前沿：单细胞遗传分析及其作用的扩大
Jack Ballantyne,Catherine M Grgicak,Michael A Marciano
Jack Ballantyne
Standard short tandem repeat (STR) DNA profiling has transformed forensic science by enabling reliable human identification across routine and complex casework. However, conventional 'bulk' DNA extraction and analysis inherently co-detect a...
Using hierarchical Bayesian modelling to assess shedder test suitability [0.03%]
利用分层贝叶斯模型评估散发试验的适用性
Duncan Taylor,Margot Minck,Adrian Linacre et al.
Duncan Taylor et al.
Advances in trace DNA analysis, in combination with increased ability to detect minute amounts of DNA, necessitated research investment into the understanding of the factors relevant to DNA-TPPR, including individuals' ability to deposit th...
An in silico evaluation of tri-allelic SNPs from 1kGP Phase IV data for distant kinship identification and mixture analysis [0.03%]
基于1kGP第四阶段三倍型SNP数据的远亲鉴定及混合斑分析的模拟研究
Linlin Zhao,Guanju Ma,Chaolong Lu et al.
Linlin Zhao et al.
Multi-allelic Single Nucleotide Polymorphisms (SNPs) are a class of genetic markers in forensic genetics, potentially offering higher discriminatory power than their bi-allelic counterparts. However, well-characterized panels specifically d...
Inheritance patterns of mitochondrial DNA in multi-generational maternal pedigrees: Insights from mitochondrial whole-genome sequencing [0.03%]
多代母系家谱中的线粒体DNA遗传模式：线粒体全基因组测序的新见解
Miaoqiang Lun,Xingyi Yang,Guichao Xiao et al.
Miaoqiang Lun et al.
Mitochondrial DNA (mtDNA) exhibits unique advantages in forensic analysis and maternal lineage identification. However, its inherent heteroplasmy presents a moderate limitation to its application in forensic genetics. The purpose of this st...
A rare and atypical case of long-distance indirect DNA transfer: Contamination from an investigator never present at the scene [0.03%]
一起罕见且非典型的长距离间接DNA污染案：从未到过现场的检验人员导致的污染事件
Linlin Gao,Zhenping Liu,Wenyan Ren et al.
Linlin Gao et al.
To maximize the usefulness of DNA obtained from biological samples in forensic genetics, it is crucial to avoid DNA contamination throughout all procedures, from sample collection at crime scenes to STR profile generation in DNA laboratorie...
Evidentiary evaluation of complex low-template DNA mixtures using high-efficiency microhaplotype panels [0.03%]
高效微等位基因检测面板在复杂低拷贝DNA混合物鉴定中的应用研究
Mengyu Tan,Jiaming Xue,Mengna Wu et al.
Mengyu Tan et al.
Low-template DNA mixtures pose substantial analytical challenges owing to limited genetic information, allelic dropout, and increasing complexity arising from multiple contributors and imbalanced mixture proportions. Using highly informativ...
Leveraging microhaplotype information from hybridization capture SNP panels to enhance pairwise kinship inference [0.03%]
利用杂交捕获SNP基因型芯片中的微嵌合体信息提高亲缘关系推断的准确性
Haoyu Wang,Tiantian Shan,Yuting Wang et al.
Haoyu Wang et al.
Hybridization capture-based single nucleotide polymorphism (SNP) panels have been widely adopted for forensic kinship inference, yet conventional analysis treats each captured SNP independently, potentially underutilizing the genetic inform...
Evaluation of AutoMate and EZ2 extraction methods with surface cleaning pretreatments for ancient DNA recovery from pre-Hispanic individual using STR and SNP analyses [0.03%]
表面清洁预处理的AutoMate和EZ2提取方法用于对史前个体进行STR和SNP分析以获取古DNA的评价研究
María Teresa Navarro-Romero,Ana Julia Aguirre-Samudio,Cecilia Martínez-Campos et al.
María Teresa Navarro-Romero et al.
The recovery of ancient DNA (aDNA) from skeletal remains continues to be a critical challenge in forensic genetics and paleogenomics due to its high fragmentation, low quantity, and susceptibility to exogenous contamination. This study asse...