Assessing the resolution of extended pedigrees using hybridization capture SNP panels: Evidence from real and simulated data [0.03%]
利用杂交捕获SNP基因组简化文库评估家系关系：来自真实数据和模拟数据的证据
Tiantian Shan,Zhigang Mao,Haoyu Wang et al.
Tiantian Shan et al.
Accurate inference of distant biological relationships remains challenging in forensic genetics. Here, we evaluated a hybridization capture SNP panel for high-resolution pairwise kinship analysis using two extended Han Chinese pedigrees (93...
Salience, legitimacy and credibility of single-cell sperm data and their evaluation [0.03%]
单精细胞数据及其评价的重要性、合法性及可信度
Catherine M Grgicak,Qhawe Bhembe,Klaas Slooten et al.
Catherine M Grgicak et al.
It is difficult to determine how many sperm donors contributed to a sample, who they were, or what number of sperm they donated. A model analyzing single-cell electropherograms (scEPG) born of diploid cells was previously introduced in [1]....
Improved deconvolution of sequenced based mixtures by extending EuroForMix [0.03%]
通过扩展EuroForMix改进基于序列的混合物的逆卷积
Ø Bleka,J González-Bao,M de la Puente et al.
Ø Bleka et al.
We present an extension of the EuroForMix model to improve genotype prediction for unknown contributors in Massively Parallel Sequencing (MPS) mixture data by incorporating marker amplification efficiency (MAE) parameters. The proposed two-...
Assessing the impact of bone type on the accuracy of methylation-based forensic age estimation [0.03%]
评估骨的类型对基于甲基化法进行法医年龄鉴定准确性的影响
Charlotte Sutter,Cordula Haas,Jacqueline Neubauer
Charlotte Sutter
Methylation-based forensic donor age estimation is an emerging field in forensic genomics. It can be used not only to estimate the age of a living person, but also to determine age-at-death of an unknown corpse or skeleton. Therefore, age e...
MitoMetrics: Incorporation of mtDNA profile discrepancies in likelihood ratio calculations [0.03%]
mitochondrial metrics：在似然率计算中纳入线粒体dna分型差异
Floor Claessens,Mikkel Meyer Andersen,Christina Amory et al.
Floor Claessens et al.
Interpretation of mitochondrial DNA (mtDNA) evidence in a forensic context faces challenges, particularly when evaluating mtDNA profiles from different tissues. In hair, for example, the segregation of mtDNA shows tight bottlenecks that can...
Shotgun DNA sequencing evidence: Sample-specific and unknown genotyping error probabilities [0.03%]
基于样本的基因型错误概率及未知基因型错误概率的连发测序证据
Mikkel Meyer Andersen
Mikkel Meyer Andersen
Many forensic genetic trace samples are of too low quality to obtain short tandem repeat (STR) DNA profiles as the nuclear DNA they contain is highly degraded (e.g., telogen hairs). Instead, performing shotgun DNA sequencing of such samples...
Internal validation of the fully continuous model in EuroForMix for its implementation in routine forensic DNA profiling [0.03%]
EuroForMix中完全连续模型的内部验证，以用于法医DNA分型的常规实施
J González-Bao,A Mosquera-Miguel,L Casanova-Adán et al.
J González-Bao et al.
Despite being increasingly more common in the forensic routine, DNA mixtures still present an important roadblock in the analysis of genetic evidence. The International Society for Forensic Genetics (ISFG) recommends the use of the Likeliho...
Large-scale analysis of DNA quantification metrics and SNP sequencing performance in unidentified human remains [0.03%]
大规模分析未知人类遗骸中DNA定量指标和SNP测序性能
Steven A Bates,Bruce Budowle,Morgan Johnson et al.
Steven A Bates et al.
Massively parallel sequencing (MPS)-based single nucleotide polymorphism (SNP) profiling is being increasingly used in forensic DNA testing, yet the informative value of common pre-sequencing DNA metrics to predict SNP profile completeness ...
Mutation or uniparental disomy? Evaluating abnormal inheritance patterns using Object-Oriented Bayesian Networks [0.03%]
突变还是单亲二体？利用面向对象的贝叶斯网络评估异常遗传模式
Eduardo Avila,Cássio Ritzel,Márcio Dorn et al.
Eduardo Avila et al.
Current methods of analysis in paternity testing are often based on the assumption that most incompatibilities observed between the child and the parents genetic profiles have a paternal origin. In addition, many inconsistencies are commonl...
Comparative evaluation of SNP sequencing workflows for identification of the missing in Vietnam [0.03%]
越南失踪人员鉴定的SNP测序流程比较评估研究
Bethany K Forsythe,Bas van Haperen,Lisa Vangeel et al.
Bethany K Forsythe et al.
Hundreds of thousands of remains are still unidentified following the 1955-1975 conflict in Vietnam. DNA identification is increasingly challenging due to extreme degradation of remaining DNA, a large amount of contaminating microbial DNA, ...