Engineered extracellular vesicles enriched with the miR-214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer [0.03%]
富集miR-214/199a簇的工程化细胞外囊泡可增强卵巢癌化疗疗效
Weida Wang,Ayesha Alvero,Yi Qin et al.
Weida Wang et al.
Recurrent ovarian cancer (OC) remains a major cause of mortality due to chemoresistance and metastasis. Epigenetic aberrations, particularly dysregulated microRNA (miRNA) expression, contribute to disease progression and represent a promisi...
Norbert Wronski,Sławomir Lasota,Ewelina Madej et al.
Norbert Wronski et al.
Receptor-interacting protein kinase 4 (RIPK4) has been implicated in the progression of numerous tumours. In nonmelanoma skin cancer, RIPK4 plays a suppressor role, whereas in melanoma, it functions as an oncogene that modulates key signall...
TRAIL-PEG-Apt-PLGA nanosystem as an aptamer-targeted drug delivery system potential for triple-negative breast cancer therapy using in vivo mouse model [0.03%]
一种用于三阴性乳腺癌治疗的体内小鼠模型的适配子靶向递送系统TRAIL-PEG-Apt-PLGA纳米体系的研究
Gulen Melike Demirbolat,Aslihan Kucuk,Omer Erdogan et al.
Gulen Melike Demirbolat et al.
Targeted drug therapy is very important for the treatment of triple-negative breast cancer (TNBC), and the development of carrier systems to deliver apoptosis-inducing proteins such as TRAIL to cells is important in cancer therapy. In this ...
Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer [0.03%]
醛醇脱氢酶1A1基因减弱增加结直肠癌转移潜能和恶性程度
Martina Poturnajova,Zuzana Kozovska,Ondrej Pos et al.
Martina Poturnajova et al.
Colorectal cancer ranks third in global incidence and second in cancer mortality. Patient-derived models are irreplaceable for studying tumor biology. We established a human epithelial cell line from a rectal adenocarcinoma overexpressing c...
Colorectal cancer-derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver [0.03%]
结直肠癌衍生的FGF19是一种代谢活跃的血清生物标志物，在小鼠肝脏中发挥内分泌效应
Jordan M Beardsley,Michael W Rohr,Joseph A Goode et al.
Jordan M Beardsley et al.
Despite having excellent prognosis when detected early, colorectal cancer (CRC) remains a leading cause of cancer-related deaths globally. Screening remains an important contributor to CRC survival, but the cost and invasiveness of traditio...
Targeted modulation of IGFL2-AS1 reveals its translational potential in cervical adenocarcinoma [0.03%]
靶向调节IGFL2-AS1揭示其在宫颈腺癌中的翻译潜能
Ricardo Cesar Cintra,Lucca Paolo Hsu Helmich,Daniel Rodrigues de Bastos et al.
Ricardo Cesar Cintra et al.
Cervical cancer remains a leading cause of mortality among women, particularly in low- and middle-income countries. Despite distinct prognoses and clinical outcomes between its main histological subtypes, squamous cell carcinoma (SCC) and a...
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity [0.03%]
过氧化酶通过抑制自然杀伤细胞毒性促进黑色素瘤免疫逃脱
Hsu-Min Sung,David Bickel,Lena C M Krause et al.
Hsu-Min Sung et al.
Peroxidasin (PXDN), an extracellular matrix (ECM)-associated peroxidase, has been implicated in cancer progression. However, its roles in melanoma biology and therapeutic sensitivity remain unclear. Here, we demonstrate that elevated PXDN e...
Tumor mutational burden as a determinant of metastatic dissemination patterns [0.03%]
肿瘤突变负荷决定转移性播散模式
Eduardo Candeal,Andrea Moreno-Manuel,Miguel Salvadó-Pertierra et al.
Eduardo Candeal et al.
According to the seed and soil hypothesis, the organ specificity of metastasis is not a random process and depends on multiple tumor-intrinsic and microenvironmental factors. In this study, we characterized the mutational landscape of a lar...
Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer [0.03%]
整合的基因组和蛋白质组分析揭示了宫颈癌放化疗抵抗的机制
Janani Sambath,Irene A George,Srikanth S Manda et al.
Janani Sambath et al.
Cervical cancer is highly prevalent in India, with most cases being diagnosed at advanced stages. Despite the standard concurrent chemoradiotherapy (CCRT), 30-40% of patients' experience treatment failure, underscoring the need for improved...
RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects [0.03%]
RaMBat：从具有严重批次效应的多样化数据源中准确识别髓母细胞瘤亚型
Mengtao Sun,Jieqiong Wang,Shibiao Wan
Mengtao Sun
As the most common pediatric brain malignancy, medulloblastoma (MB) includes multiple distinct molecular subtypes characterized by clinical heterogeneity and genetic alterations. Accurate identification of MB subtypes is essential for downs...