Loss of IGF-1R impairs DNA-PKcs recruitment to chromatin leading to defective end-joining [0.03%]
IGF-1R丢失导致DNA-PKcs不能招募到染色质中从而造成末端连接缺陷
Matthew O Ellis,Jack V Mills,Wojciech Niedzwiedz et al.
Matthew O Ellis et al.
The insulin-like growth factor (IGF) axis regulates cancer cell proliferation, growth, invasion, and therapy resistance. Elevated expression of the type 1 IGF receptor (IGF-1R) is linked to radioresistance and biochemical recurrence in pros...
Clinical performance of the urine-based TERT promoter AbsoluteQ Digital PCR for non-invasive detection of bladder cancer [0.03%]
基于尿液的TERT启动子AbsoluteQ数字PCR技术在膀胱癌无创诊断中的临床性能评估
Anna Nykel,Izabela Kubiak,Lena Rutkowska et al.
Anna Nykel et al.
Bladder cancer (BC) is the ninth most common cancer worldwide, with urothelial carcinoma accounting for approximately 90% of all cases and presenting predominantly as non-muscle-invasive disease. Due to its high recurrence rate and the need...
Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off-the-shelf targeted NGS panel [0.03%]
基于现货型NGS靶向基因检测的子宫内膜癌患者纵向循环肿瘤DNA分析研究
Carlos Casas-Arozamena,Karin Teien Lande,Eva Diaz et al.
Carlos Casas-Arozamena et al.
Intratumor heterogeneity presents a major challenge in precision oncology for endometrial cancer (EC). Circulating tumor DNA (ctDNA) offers a minimally invasive method to monitor tumor evolution and therapeutic resistance. In this retrospec...
DNA methylation and expression of MAPRE3 affect overall survival of early-stage non-small cell lung cancer patients [0.03%]
Chao Chen,Jiancheng Cheng,Ruili Hou et al.
Chao Chen et al.
The MAPRE3 gene is aberrantly expressed in several cancers. We profiled DNA methylation in tumor tissues from early-stage non-small cell lung cancer (NSCLC) patients and assessed associations with overall survival (OS). Significant CpG prob...
Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients [0.03%]
循环肿瘤细胞在放疗过程和之后的存活率反映了癌症患者的治疗反应
Yvonne Goy,Jana Löptien,Cornelia Coith et al.
Yvonne Goy et al.
The response to radiotherapy (RT) is influenced by the individual DNA repair capacity of both the tumor cells and the host. In this study, we assessed whether circulating tumor cell (CTC) enumeration, kinetics, and CTC viability (i.e., the ...
EDNRB-dependent endothelin signaling reduces proliferation and promotes proneural-to-mesenchymal transition in gliomas [0.03%]
EDNRB依赖性的内皮素信号减少胶质瘤的增殖并促进其从神经元向间叶细胞的转变
Donovan Pineau,Leonor Garcia,Hugo Arnold et al.
Donovan Pineau et al.
Diffuse gliomas are primary brain tumors including glioblastomas (GB), astrocytomas, and oligodendrogliomas, the latter two harboring IDH1 mutations and exhibiting slower progression. Gliomas display cellular plasticity, with transitions be...
CCDC80 suppresses high-grade serous ovarian cancer migration via negative regulation of B7-H3 [0.03%]
CCDC80通过负向调节B7-H3抑制高等级浆液性卵巢癌迁移
Aya Saleh,Nitzan Medina-Itzhaki,Milena Chekov et al.
Aya Saleh et al.
Paired box protein Pax-8 (PAX8) is a critical lineage marker and master regulator of transcription in high-grade serous ovarian carcinoma (HGSC)-the most common subtype of epithelial ovarian cancer-driving cell proliferation and migration a...
CD47 promotes mitogen-activated protein kinase and epithelial-to-mesenchymal transition molecular programs to drive prometastatic phenotypes in non-small cell lung cancer [0.03%]
CD47通过促进有丝分裂原活化的蛋白激酶和上皮间质转化分子程序来驱动非小细胞肺癌的促转移表型
Asa P Y Lau,Lilian G Zhai,Ryunosuke Hoshi et al.
Asa P Y Lau et al.
CD47 is best known for its role in tumor immune evasion; however, studies in diverse cell models indicate that it also has cell autonomous, tumor-promoting functions which are cell type- and context-specific. Motivated by the prognostic and...
Julie M Mazet,Johanna A Joyce
Julie M Mazet
Stem-like T cells are central to the efficacy of programmed cell death protein 1 (PD1) blockade, sustaining long-term immune responses by serving as a renewable reservoir for anti-tumor effector CD8+ T cells. However, the mechanisms governi...