Lipocalin 2 promotes inflammatory breast cancer tumorigenesis and skin invasion [0.03%]
脂联素2促进炎性乳腺癌的肿瘤发生和皮肤浸润
Emilly S Villodre,Xiaoding Hu,Richard Larson et al.
Emilly S Villodre et al.
Inflammatory breast cancer (IBC) is an aggressive form of primary breast cancer characterized by rapid onset and high risk of metastasis and poor clinical outcomes. The biological basis for the aggressiveness of IBC is still not well unders...
Metagenomic analysis of primary colorectal carcinomas and their metastases identifies potential microbial risk factors [0.03%]
元基因组分析鉴定原发性结直肠癌及其转移灶中的潜在微生物危险因素
Luigi Marongiu,Jonathan J M Landry,Tobias Rausch et al.
Luigi Marongiu et al.
The paucity of microbiome studies at intestinal tissues has contributed to a yet limited understanding of potential viral and bacterial cofactors of colorectal cancer (CRC) carcinogenesis or progression. We analysed whole-genome sequences o...
Emerging methods for prostate cancer imaging: evaluating cancer structure and metabolic alterations more clearly [0.03%]
前列腺癌影像的新兴方法：更清晰地评估癌症结构和代谢改变
Adam Retter,Fiona Gong,Tom Syer et al.
Adam Retter et al.
Imaging plays a fundamental role in all aspects of the cancer management pathway. However, conventional imaging techniques are largely reliant on morphological and size descriptors that have well-known limitations, particularly when conside...
FANCD2 limits acetaldehyde-induced genomic instability during DNA replication in esophageal keratinocytes [0.03%]
FANCD2在食道角质细胞DNA复制过程中限制乙醛引起的基因组不稳定事件
Jasmine D Peake,Chiaki Noguchi,Baicheng Lin et al.
Jasmine D Peake et al.
Individuals with Fanconi anemia (FA), a rare genetic bone marrow failure syndrome, have an increased risk of young-onset head and neck squamous cell carcinomas (SCCs) and esophageal SCC. The FA DNA repair pathway is activated upon DNA damag...
Therapeutic potential of the human endogenous retroviral envelope protein HEMO: a pan-cancer analysis [0.03%]
人源内源性逆转录病毒包膜蛋白HEMO的治疗潜力：泛癌分析
Amélie Kasperek,Anthony Béguin,Olivia Bawa et al.
Amélie Kasperek et al.
Human endogenous retroviruses represent approximately 8% of our genome. Most of these sequences are defective except for a few genes such as the ancestral retroviral HEMO envelope gene (Human Endogenous MER34 ORF), recently characterized by...
VprBP directs epigenetic gene silencing through histone H2A phosphorylation in colon cancer [0.03%]
结肠癌中VprBP通过组蛋白H2A磷酸化介导表观遗传沉默作用
Nikhil Baban Ghate,Sangnam Kim,Erin Spiller et al.
Nikhil Baban Ghate et al.
Histone modification is aberrantly regulated in cancer and generates an unbalanced state of gene transcription. VprBP, a recently identified kinase, phosphorylates histone H2A on threonine 120 (T120) and is involved in oncogenic transcripti...
A comprehensive analysis of SNPs and CNVs identifies novel markers associated with disease outcomes in colorectal cancer [0.03%]
综合分析SNP和CNV可识别结直肠癌相关的新疾病标志物
Yajun Yu,Salem Werdyani,Megan Carey et al.
Yajun Yu et al.
We aimed to examine the associations of a genome-wide set of single nucleotide polymorphisms (SNPs) and 254 copy number variations (CNVs) and/or insertion/deletions (INDELs) with clinical outcomes in colorectal cancer patients (n = 505). We...
The signal transducer CD24 suppresses the germ cell program and promotes an ectodermal rather than mesodermal cell fate in embryonal carcinomas [0.03%]
信号转导器CD24通过抑制生殖细胞程序并在胚胎癌中促进外胚层细胞命运而非中胚层细胞命运来发挥抑癌作用
Margaretha A Skowron,Teresa K Becker,Lukas Kurz et al.
Margaretha A Skowron et al.
Testicular germ cell tumors (GCTs) are stratified into seminomas and nonseminomas. Seminomas share many histological and molecular features with primordial germ cells, whereas the nonseminoma stem cell population-embryonal carcinoma (EC)-is...
Sphingolipid metabolism in the development and progression of cancer: one cancer's help is another's hindrance [0.03%]
鞘脂代谢在癌症发生和发展中的作用：甲之蜜糖乙之砒霜
Antonia Piazzesi,Sumaiya Yasmeen Afsar,Gerhild van Echten-Deckert
Antonia Piazzesi
Cancer development is a multistep process in which cells must overcome a series of obstacles before they can become fully developed tumors. First, cells must develop the ability to proliferate unchecked. Once this is accomplished, they must...