TRIM38 alleviates the pathogenesis of diabetic nephropathy by suppressing NF-κB activation via inducing RIPK1 degradation [0.03%]
TRIM38通过诱导RIPK1降解抑制NF-κB激活从而缓解糖尿病肾病病理进程
Yifan Fang,Xiaojuan Rao,Jianlin Dou et al.
Yifan Fang et al.
Diabetic nephropathy (DN), a major microvascular complication of diabetes, remains a leading cause of end-stage renal disease. Tripartite motif protein 38 (TRIM38), a member of the TRIM family, plays critical roles in apoptosis, innate immu...
Dietary bioactive compounds modulating satiety and appetite: mechanisms of action [0.03%]
能够调节饱腹感和食欲的膳食活性化合物：作用机制
Gema Casado-Hidalgo,Marián Pueyo-Arias,Katherine Gil-Cardoso et al.
Gema Casado-Hidalgo et al.
Obesity and overweight represent critical public health problems worldwide, driving the search for effective strategies for their prevention and treatment. Modulating appetite and satiety through natural compounds present in the diet emerge...
Therapeutic effects of chitooligosaccharide-epigallocatechin gallate conjugate on NAFLD: impact on gut-liver axis, lipid metabolism, and inflammation in rats fed a high-fat diet [0.03%]
壳寡糖-儿茶素结合物对高脂饮食诱导的非酒精性脂肪肝的治疗作用：对肠-肝轴、脂质代谢和炎症的影响
Sirikul Mueangaun,Kanokrada Tonphu,Natcha Lerkdumnernkit et al.
Sirikul Mueangaun et al.
Non-alcoholic fatty liver disease (NAFLD) is a progressive disorder correlated with hepatic lipid homeostasis, gut dysbiosis, and inflammation. In this study, we propose a novel dietary therapy for NAFLD utilizing a conjugate of chitooligos...
Evaluation of an experimental model of senescence SAMR1/SAMP8 for microRNA studies in acute myocardial infarction: role of sex and aging [0.03%]
评估SAMR1/SAMP8衰老实验模型在急性心肌梗死中对微小核糖核酸研究的作用：性别和年龄的影响
A B Paes,B Descals-Beltrán,C Rosales-Ariza et al.
A B Paes et al.
Age and sex are critical yet often overlooked variables in preclinical models of acute myocardial infarction (AMI), potentially limiting the translational relevance of molecular findings. In this study, we used the Senescence-Accelerated Mo...
The progress of mitochondrial function and transfer in stem cell regulation and therapy [0.03%]
干细胞调控和治疗中线粒体功能和转移的研究进展
Yubing Zhang,Zhuojian Qu,Zhiliang Guo et al.
Yubing Zhang et al.
Mitochondria, serving as central organelles for energy metabolism, play a critical regulatory role in stem cell self-renewal and differentiation-a function increasingly supported by accumulating evidence and closely linked to various aging-...
Chrono overexpression blunts exercise-induced improvement in muscular glucose metabolism by inhibiting the BMAL1 transcriptional activity in high-fat diet-fed mice [0.03%]
慢性过表达通过抑制BMAL1转录活性而削弱运动对高脂饮食小鼠肌糖原代谢改善作用
Lei Xu,Jie Jia,Lu Yan et al.
Lei Xu et al.
Aerobic exercise improves systemic insulin sensitivity by modulating muscle glucose metabolism. The CHRONO/BMAL1 pathway constitutes a core component of the endogenous molecular clock and participates in glucose metabolic regulation; howeve...
Exercise-induced modulation of the unfolded protein response: a therapeutic avenue for muscle wasting disorders [0.03%]
运动引起的未折叠蛋白反应调节作用：肌肉萎缩症的治疗途径
Ao Ke,Zhuo Jinyuan,Lijuan Xiang et al.
Ao Ke et al.
Muscle wasting, prevalent in various pathological conditions including cancer, cardiac dysfunction, and neurodegeneration, is typified by sustained protein depletion in muscle and a compromised ability of the tissue to repair and regenerate...
Gut dysbiosis and nitric oxide dysregulation in cirrhosis progression: mechanistic insights and pathophysiological implications [0.03%]
肝硬化的进展中的肠道菌群失调和一氧化氮调节障碍：机制见解与病理生理意义
Vlad Răzniceanu,Andra Țichindeleanu,Eugen-Valentin Răducu et al.
Vlad Răzniceanu et al.
Cirrhosis represents the end stage of chronic liver injury, characterized by progressive fibrosis and architectural distortion that precipitate portal hypertension and systemic complications. Recent evidence positions gut microbiota dysbios...
Renal proteomics of male offspring exposed to maternal protein restriction: molecular, epigenetic, and nephron-specific signatures of metabolic programming [0.03%]
母体蛋白质限制暴露的雄性后代肾脏蛋白质组学：代谢编程的分子、表观遗传和肾单位特异性标志物
Danielle Amanda Niz Alvarez,Isabelle Tenori Ribeiro,Matheus Naia Fioretto et al.
Danielle Amanda Niz Alvarez et al.
Chronic kidney disease is an increasing global public health concern, and the Developmental Origins of Health and Disease (DOHaD) concept proposes that adverse conditions during critical developmental windows predispose offspring to chronic...