Effectiveness of dietary modifications in reversing damage induced by high-fat diet in rats [0.03%]
饮食干预逆转高脂膳食诱导大鼠肠道损伤的效果研究
Manuel Jiménez-García,Maria Magdalena Quetglas-Llabrés,Susana Esteban-Valdés et al.
Manuel Jiménez-García et al.
Excessive dietary fat intake is a major health concern, contributing to the increasing prevalence of Metabolic Dysfunction Associated with Fatty Liver Disease (MAFLD) worldwide; different prevalence between sexes has been postulated but it ...
Adipose-derived mesenchymal stem cells improved acute renal failure induced by ischemia-reperfusion injury: Focusing on toll-like receptor 4 activity and endoplasmic reticulum stress response [0.03%]
脂肪来源的间充质干细胞改善缺血再灌注损伤诱导的急性肾功能衰竭：重点关注 Toll 样受体 4 活性和内质网应激反应
Leila Hafazeh,Mehri Kadkhodaee,Behjat Seifi et al.
Leila Hafazeh et al.
This study evaluated the efficacy of adipose-derived mesenchymal stem cells (AD-MSCs) in reducing pathological alterations linked to acute kidney injury (AKI) caused by ischemia-reperfusion injury (IRI). In this study, 18 male rats were div...
Unveiling the role of CB2 receptor in beta-hydroxybutyrate mediated modulation of [0.03%]
CB2受体在β-羟基丁酸介导的调节中的作用机制探究
Monika Iešmantaitė,Liutauras Usonis,Kristupas Čeika et al.
Monika Iešmantaitė et al.
The cannabinoid receptor type 2 (CB2R), primarily expressed in microglia, the brain's resident immune cells, acts as a central regulator of neuroinflammatory responses. When CB2R is activated, it triggers anti-inflammatory signaling, making...
Relationship between muscle FNDC5, FGF21 mRNA, miR-150 and bone loss after sciatic denervation [0.03%]
坐骨神经切断去神经后肌肉FNDC5、FGF21 mRNA及miR-150与骨丢失的关系研究
Teresa Priego,Elena Nebot-Valenzuela,Álvaro Moreno-Rupérez et al.
Teresa Priego et al.
It has been proposed that muscle influences adjacent bones, but the mechanisms by which muscle regulates bone physiology are not fully understood. Sciatic denervation is an experimental model that induces both skeletal muscle atrophy and os...
The regulatory effects of extracellular vesicles derived from adipose stem cells on tumor biological activity [0.03%]
来源于脂肪干细胞的细胞外囊泡对肿瘤生物学活性的调控作用
Ziyue Qi,Xiaoyun Zhang,Mengyan Liu et al.
Ziyue Qi et al.
The field of malignant tumor diagnosis and treatment urgently requires innovative research perspectives to overcome the existing limitations. Extracellular vesicles (EVs) are crucial mediators of intercellular communication, offering novel ...
METTL3 suppresses pyroptosis in obstructive sleep apnea-associated hypertension via YTHDF2-mediated SOX4 mRNA degradation [0.03%]
METTL3通过YTHDF2介导的SOX4 mRNA降解抑制阻塞性睡眠呼吸暂停相关高血压中的细胞焦亡
Wenjun Zhu,Yanyan Hou,Can Yang et al.
Wenjun Zhu et al.
Obstructive sleep apnea (OSA) is frequently complicated by hypertension, with approximately 60% of patients exhibiting both conditions. However, the epigenetic mechanisms underlying this comorbidity remain largely unexplored. N6-methyladeno...
Mitochondria-sarcoplasmic reticulum crosstalk as a modulator of skeletal muscle mass [0.03%]
线粒体-肌浆网信号在调节骨骼肌质量中的作用
Rafael A Casuso
Rafael A Casuso
Preservation of skeletal muscle mass and function is a key feature of healthy ageing and relies on the tight coordination between protein synthesis and breakdown to maintain proteostatic balance. These processes impose a substantial energet...
Gene arrangement within concatemeric constructs governs the functional divergence of human and rat ASIC3 concatemers [0.03%]
基因排列影响人类和大鼠ASIC3串联体的功能分化
Dmitry I Osmakov,Yuliya V Korolkova,Ekaterina E Maleeva et al.
Dmitry I Osmakov et al.
Acid-sensing ion channels (ASICs) are proton-gated sodium channels encoded by four genes in mammals. The ASIC3 isoform is widely expressed and plays a critical role in pain signaling and inflammatory responses. Despite a high degree of sequ...
The two faces of mitochondrial Ca2+ dysregulation in skeletal muscle: overload and deficiency [0.03%]
线粒体钙离子调节失常的两面性：过多与不足
Mikhail V Dubinin,Konstantin N Belosludtsev
Mikhail V Dubinin
Mitochondrial Ca²⁺ dysregulation is a central pathogenic event in skeletal muscle disorders, yet the dichotomy between overload and deficiency is often overlooked. This review summarizes mechanisms governing mitochondrial Ca²⁺ transport...
DGAT1 regulates keratinocyte proliferation through the modulation of retinoid homeostasis [0.03%]
DGAT1通过调节类视黄醇稳态来调控角质形成细胞增殖
Kamila Kwiecień,Natalia Bryniarska-Kubiak,Agnieszka Morytko et al.
Kamila Kwiecień et al.
Multiple mechanisms contribute to skin barrier integrity, and emerging evidence suggests that acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) plays a key role in its regulation through both lipid and retinoid metabolism. Although DGAT1 de...