Oral lipoteichoic and lipoic acids improve insulin resistance and body composition in porphyria mice on a high-carbohydrate diet [0.03%]
口服脂糖酸和脂酰酸可改善高碳水化合物饮食条件下血紫质小鼠的胰岛素抵抗和身体组成比例
Miriam Longo,Teresa Rubio,Araceli Lamelas et al.
Miriam Longo et al.
Acute intermittent porphyria (AIP) is a genetic metabolic disorder characterized by neurovisceral attacks. Although high-carbohydrate diets or intravenous glucose administration can help alleviate incipient attacks in patients, these interv...
Subchronic modulation of bitter taste receptors (TAS2R) by procyanidins. Unravelling the complex interplay between stimulation and expression [0.03%]
(procyanidins的)亚慢性调节苦味受体(TAS2R). 解开刺激和表达之间的复杂相互作用
Florijan Jalsevac,Maria Descamps-Solà,Adrià Vilalta et al.
Florijan Jalsevac et al.
Mediated by the bitter taste receptors (TAS2R), the perception of bitter taste does not only involve the oral cavity but various physiological systems throughout the gastrointestinal tract. The relationship between stimulation and modulatio...
TRPM8-driven thermogenesis by menthol: mechanisms of cold injury prevention [0.03%]
薄荷素通过瞬时受体电位锚蛋白8通道介导的产热作用及冷损伤预防机制研究
Yujie Li,Yuanyuan Song,Xin Yang et al.
Yujie Li et al.
Cold injury presents a significant health challenge, causing tissue damage due to prolonged exposure to low temperatures. This study examines menthol's protective effects against cold injury, focusing on its activation of transient receptor...
Impact of toll-like receptors on food allergy. mechanisms involved and scientific evidence [0.03%]
toll-like受体对食物过敏的影响及机制和实验证据
Sergio Álvarez-Azcarreta,Wissal Mountasar-Didouch,Adrián Macho González et al.
Sergio Álvarez-Azcarreta et al.
Food allergy (FA) is an exacerbated immune system response to harmless food antigens following sensitization. The incidence of FA has risen significantly over the past two decades, a trend often attributed to modern lifestyle factors such a...
Ceramides in non-communicable diseases: pathways, nutritional modulation, and therapeutic opportunities [0.03%]
ceramide在非传染性疾病中的作用:pathways、营养调节和治疗机会
Marcia Ribeiro,Livia Alvarenga,Danielle Nascimento et al.
Marcia Ribeiro et al.
Ceramides are sphingolipids formed from fatty acids linked to sphingosine and an amide, which are involved in cellular pathways such as apoptosis, fibrosis, oxidative stress, and inflammation. Six distinct fatty acyl selective ceramide synt...
Long non-coding RNA NR2F1-AS1: an increasingly significant LncRNA in human cancers [0.03%]
长链非编码RNA NR2F1-AS1：在人类癌症中作用渐显的LncRNA
Qinfan Yao,Xinyi Zhang,Yitong Chen et al.
Qinfan Yao et al.
Long non-coding RNAs (lncRNAs), defined as transcripts exceeding 200 nucleotides without protein-coding potential, have emerged as pivotal regulators in diverse physiological and pathological processes, particularly in tumorigenesis. Among ...
Thamer Abdulla Mohammed,Munaf H Zalzala
Thamer Abdulla Mohammed
The farnesoid X receptor (FXR), a nuclear receptor (NR), plays a key role in balancing bile acid (BA), lipid, and glucose metabolism. By partnering with the retinoid X receptor (RXR), FXR influences gene transcription critical to these meta...
Zisheng Huang,Weili Gu,Tao-Sheng Li
Zisheng Huang
The multifaceted regulation of white adipose tissue browning and their therapeutic potential [0.03%]
白色脂肪组织褐变的多重调控及潜在治疗价值
Abhishek Satheesan,Janardanan Kumar,Kakithakara Vajravelu Leela et al.
Abhishek Satheesan et al.
Adipose tissue browning, the conversion of white adipose tissue (WAT) into brown or beige adipose tissue, offers potential for combating obesity and metabolic disorders. This review delves in to the transcriptional and epigenetic regulation...
Alpha-ketoglutarate supplementation differently modifies hematological parameters and oxidative stress in mice fed a standard diet and high-fat high-fructose diet [0.03%]
α-酮戊二酸补剂对标准饮食和高脂高果糖饮食小鼠的血液学指标和氧化应激的影响不同
Myroslava V Vatashchuk,Viktoriia V Hurza,Oleksandra B Abrat et al.
Myroslava V Vatashchuk et al.
Long-term consumption of high-calorie diets can lead to metabolic disorders. In this study, we evaluated the effects of an eight-week standard (control), high-fat high-fructose (HFFD), alpha-ketoglutarate (AKG)-supplemented (1% in drinking ...