Can regulators have a role in facilitating the development of new medicines for Parkinson's disease? [0.03%]
监管机构能促进帕金森病新药研发吗？
Mário Miguel Rosa,Ewa Balkowiec-Iskra
Mário Miguel Rosa
Parkinson's disease (PD) is the second most frequent neurodegenerative disorder, and its prevalence has doubled in the past 25 years. New formulations of levodopa have recently been marketed that improved the ability to treat PD, but in the...
DBS-STN&SNr combined stimulation versus DBS-STN monotarget stimulation for Parkinson's disease freezing: A comparative efficacy study [0.03%]
用于帕金森病冻结的双侧STN-SNr联合刺激与单侧STN刺激对照疗效研究
Bo Tan,Tao Chen,Peng Guo et al.
Bo Tan et al.
BackgroundFreezing of gait (FOG) is a common and disabling symptom in patients with Parkinson's disease (PD), significantly impairing motor function and quality of life. While traditional deep brain stimulation (DBS) of the subthalamic nucl...
Shades of grey: The continuum of therapies for Parkinson's disease along the spectrum of credibility [0.03%]
从可信度谱系看帕金森病的治疗连续体及灰色地带
Araceli Alonso-Canovas,Olaf M Dekkers,Bas Bloem
Araceli Alonso-Canovas
Complementary and alternative therapies (CAT) is an umbrella term applied to a diverse set of approaches, with high interest among persons with Parkinson's disease. However, scientific community regards evidence-based medicine as the only a...
Progression to Parkinson's dementia is not modulated by genetic risk variants for Alzheimer's or Parkinson's disease [0.03%]
阿尔茨海默病或帕金森病的遗传风险变异不会影响帕金森病性痴呆的发生发展
Kayenat Parveen,J Alexander Ross,Hendrik van der Wurp et al.
Kayenat Parveen et al.
Parkinson's disease (PD) is marked by motor symptoms and often accompanied by mild cognitive impairment (PD-MCI), affecting up to 50% of patients and preceding PD dementia (PDD). Genetic factors may influence this progression, yet the under...
Early detection of Parkinson's disease: Machine learning-based prediction of UPDRS Part III scores in de novo patients using smartphone assessments [0.03%]
基于机器学习的智能手机评估在新发帕金森病患者中的早期发现：预测UPDRS III项评分
Wei-Hang Guo,Xiao-Dong Yang,Zheng Ruan et al.
Wei-Hang Guo et al.
BackgroundDetecting motor symptoms in Parkinson's disease (PD) at home, especially in the prodromal, is crucial for disease-modifying therapies.ObjectiveTo evaluate the effectiveness of machine learning models using smartphone-based assessm...
Utility of a newly created questionnaire on subtle motor symptoms in high-risk subjects with Parkinson's disease [0.03%]
帕金森病高风险对象中一种新创建的微妙运动症状问卷的有效性
Daigo Tamakoshi,Keita Hiraga,Taiki Fukushima et al.
Daigo Tamakoshi et al.
BackgroundProdromes of Parkinson's disease (PD) include both motor and non-motor symptoms. Although questionnaires have been established for non-motor symptoms, no quantitative self-assessment tool has been developed to assess subtle motor ...
Unmet needs in the pharmacological management of motor symptoms in Parkinson's disease [0.03%]
帕金森病运动症状的药物治疗需求未被满足之处
Beatrice Heim,Werner Poewe
Beatrice Heim
Parkinson's disease (PD) is a progressive neurodegenerative disorder clinically defined by the presence of cardinal motor features like bradykinesia, rigidity and resting tremor. The mainstay of PD treatment is pharmacological dopamine subs...
SGLT2 inhibitors vs. metformin for Parkinson's disease risk reduction in type 2 diabetes [0.03%]
用于2型糖尿病的帕金森病风险降低：钠葡萄糖共转运体2抑制剂与二甲双胍的效果比较
Mingyang Sun,Xiaoling Wang,Zhongyuan Lu et al.
Mingyang Sun et al.
SummaryThis study is the first large-scale, head-to-head comparison suggesting that sodium-glucose cotransporter-2 inhibitors (SGLT2is) may offer greater neuroprotection against Parkinson's disease (PD) compared to metformin in patients wit...
Parkinson's disease and routine traffic stops: An exploration of patient experiences and perceptions [0.03%]
帕金森病与例行交通检查：患者体验和感知的探讨
Rebecca Eilish Irvine,Alexis P Kruger,Alfred Quaicoe et al.
Rebecca Eilish Irvine et al.
Parkinson's disease (PD) is a chronic neurodegenerative disorder which can impair patients' ability to complete complex motor skills, such as driving. There is currently a lack of research into the effectiveness of police officers discernin...
Nicola Rooney,Drupad K Trivedi,Eleanor Sinclair et al.
Nicola Rooney et al.
A definitive diagnostic test for Parkinson's disease (PD) remains elusive, so identification of potential biomarkers can facilitate diagnosis and early intervention. Two dogs were trained to distinguish between dry skin swabs obtained from ...