Beyond motor fluctuations: Understanding the clinical correlates of OFF burden in Parkinson's disease [0.03%]
帕金森病OFF期负担的临床相关因素：超越运动波动
David Ledingham,Sahana Sathyanarayana,Robyn Iredale et al.
David Ledingham et al.
BackgroundHistorically, OFF burden in Parkinson's disease has been primarily attributed to motor features. Recent studies highlight that non-motor symptoms, and the predictability of OFF episodes also drive functional impairment, yet they a...
Leveraging machine learning with real-world data for hypothesis generation by identifying exposomic predictors in Parkinson's disease among farmers [0.03%]
利用真实世界数据识别帕金森病农民的暴露组预测因子以进行假设生成和机器学习的研究
Pascal Petit,François Berger,Vincent Bonneterre et al.
Pascal Petit et al.
BackgroundMachine learning offers new avenues for complementing traditional epidemiological approaches by analyzing routinely collected, population-based administrative health data.ObjectiveThis study aimed to identify potential exposomic p...
Burst deep brain stimulation for Parkinson's disease: A systematic review of efficacy and safety [0.03%]
帕金森病爆破式深部脑刺激疗效和安全性的系统评价
Martijn Hendriks,Matej Lokar,Hisse Arnts et al.
Martijn Hendriks et al.
BackgroundBurst deep brain stimulation (DBS) is a promising alternative to conventional deep brain stimulation (cDBS), incorporating paradigms such as theta burst stimulation (TBS), burst cycling (BC), and coordinated reset (CR). Findings f...
Full recovery after severe bacterial encephalitis and brain abscess following deep brain stimulation surgery for Parkinson's disease [0.03%]
帕金森病深部脑刺激手术后严重细菌性脑炎和脑脓肿完全恢复的一例报告
Eline Amy Rouleau,Debby Eic Falck,Carel Fe Hoffmann et al.
Eline Amy Rouleau et al.
Encephalitis and cerebral abscesses are rare, serious complications of deep brain stimulation (DBS) surgery. We report on two patients with Parkinson's disease (PD) who developed a critical condition with focal neurological symptoms and dec...
Where does excessive beta in Parkinson's disease originate? Insights from a case of unilateral cortico-pallidal pathway dysfunction [0.03%]
帕金森病过度β活动的起源？一例半侧纹状体-苍白球通路功能障碍患者的启示
Leonardo Rigon,Valentina D&#x;Onofrio,Laura Ludovica Grassi et al.
Leonardo Rigon et al.
Plain language summaryDetecting the source of abnormal beta oscillations in Parkinson's Disease: evidence from a case of impaired connection between cerebral cortex and basal ganglia.In Parkinson's Disease, a key feature is an exaggerated, ...
Social interaction enhances the pleasurable urge to move to music in people with Parkinson's disease [0.03%]
社会互动可提高帕金森病患者对音乐律动的愉悦感和渴求感
Jan Stupacher,Peter Vuust,Victor Pando-Naude
Jan Stupacher
BackgroundMusic- and dance-based interventions can improve motor symptoms in people with Parkinson's disease (PD), but two key questions remain: whether the rhythmic complexity of music influences intervention outcomes, and whether social i...
Qualitative assessment of the clinical meaningfulness of MDS-UPDRS part III items in early-stage Parkinson's [0.03%]
帕金森病早期患者MDS-UPDRS第III部分各项指标的临床意义评估
Sophie Cleanthous,Roger A Barker,Milton Biagioni et al.
Sophie Cleanthous et al.
IntroductionDevelopers of disease-modifying therapies (DMTs) for early-stage Parkinson's are in dialogue with regulators to identify the relative merits of the Movement Disorder Society - Unified Parkinson's Disease Rating Scale (MDS-UPDRS)...
Greater burden of Alzheimer's Co-pathology in women with Parkinson's disease dementia [0.03%]
帕金森病痴呆女性患者中较高的阿尔茨海默病共病理负荷
Nathaniel Dunckley,Erika D Driver-Dunckley,Nan Zhang et al.
Nathaniel Dunckley et al.
ObjectiveTo investigate sex differences in Alzheimer's disease (AD) related pathology among autopsy-confirmed Parkinson's disease (PD) cases.BackgroundAD and PD frequently co-occur in older adults, yet the influence of sex on AD pathology i...
Parkinsonism induced by carbon monoxide intoxication: A "hidden gem" in the neurological literature [0.03%]
一氧化碳中毒引起的帕金森综合征：神经病学文献中的“隐藏宝藏”
Omer Abdullah,Peter A LeWitt
Omer Abdullah
Parkinsonism can be acquired by various toxic exposures, among them carbon monoxide. Since the publication of a 1972 report of Parkinsonism associated with repeated episodes of carbon monoxide exposure, the medical literature has recorded m...
Regulatory endorsement for the application of α-synuclein seed amplification assay as a susceptibility and risk biomarker for clinical trials targeting synucleinopathies [0.03%]
α-突触核蛋白种子增殖试验作为针对包涵体肌炎临床试验的易感性和风险生物标志物的应用监管批准
Diane Stephenson,Luis Concha-Marambio,Tom Lanz et al.
Diane Stephenson et al.
Transformation in the neurosciences in biomarkers is enabling novel therapeutic strategies targeting earlier stages of disease prior to onset of clinical symptoms. Emerging progress in the area of synucleinopathies, including Parkinson's di...