GBA1 variants and mortality in Parkinson's disease: A systematic review and meta-analysis [0.03%]
帕金森病的GBA1变异与死亡率：系统评价和Meta分析
Nathan Chan,Anthony Raphael,Justin Kim et al.
Nathan Chan et al.
BackgroundVariants in the GBA1 gene are a common genetic risk factor for Parkinson's disease (PD). While GBA1-PD is associated with more rapid motor and cognitive decline, evidence regarding impact on survival remains debatable.ObjectivesTh...
Meditation and breathwork on anxiety in Parkinson's disease: A pilot randomized controlled trial [0.03%]
帕金森病患者焦虑的冥想和呼吸练习干预研究：一项随机对照试验试点项目
Akila Rayapuraju,Preeti U Reed,Jennifer Liu et al.
Akila Rayapuraju et al.
BackgroundAnxiety and other non-motor symptoms can greatly diminish quality of life in people with Parkinson's Disease (PD). Yet, few randomized controlled trials (RCTs) have assessed accessible, non-pharmacological mental health treatments...
Lack of genetic evidence for a role of SLC25A46 in alpha-synucleinopathies [0.03%]
缺乏SLC25A46在α-突触核蛋白病中发挥作用的遗传证据
Han Yu,Sitki Cem Parlar,Konstantin Senkevich et al.
Han Yu et al.
BackgroundThe SLC25A46 gene encodes a mitochondrial carrier protein previously implicated in neuropathy and optic atrophy. Biallelic variants in SLC25A46 have been described in patients with Parkinson's disease (PD) with optic atrophy, but ...
Blue light therapy delivered through light glasses improves sleep quality and daytime sleepiness in Parkinson's disease: A randomized trial [0.03%]
通过光眼镜递送的蓝光疗法可改善帕金森病患者的睡眠质量和日间嗜睡：一项随机试验
Katarzyna Śmiłowska,Nienke M de Vries,Bastiaan R Bloem et al.
Katarzyna Śmiłowska et al.
BackgroundSleep disturbances, including excessive daytime sleepiness (EDS) and fragmented nocturnal sleep, are common in Parkinson's disease (PD) and significantly reduce quality of life. This pilot study evaluated the efficacy of a novel a...
Lorenzo Malfer,Capucine Piat,Aidan F Mullan et al.
Lorenzo Malfer et al.
Juvenile Parkinson's disease (JPD) is a rare condition characterized by the onset of parkinsonian motor symptoms before the age of 21. Sixteen patients with JPD who presented to the Mayo Clinic between 1990-2020 were included. The median ag...
Automatic sleep staging and atonia detection in RBD using single-channel chin EMG [0.03%]
单导下颌肌电图在REM睡眠行为障碍中的自动分期及张力丧失检测
Hans Van Gorp,Jaap F Van Der Aar,Ruud Jg Van Sloun et al.
Hans Van Gorp et al.
Study ObjectivesThe diagnosis of rapid eye movement (REM) sleep behavior disorder (RBD) is of clinical interest, as there is a high rate of future conversion to Parkinson's disease and related neurodegenerative disorders. The clinical stand...
Beyond motor fluctuations: Understanding the clinical correlates of OFF burden in Parkinson's disease [0.03%]
帕金森病OFF期负担的临床相关因素：超越运动波动
David Ledingham,Sahana Sathyanarayana,Robyn Iredale et al.
David Ledingham et al.
BackgroundHistorically, OFF burden in Parkinson's disease has been primarily attributed to motor features. Recent studies highlight that non-motor symptoms, and the predictability of OFF episodes also drive functional impairment, yet they a...
Leveraging machine learning with real-world data for hypothesis generation by identifying exposomic predictors in Parkinson's disease among farmers [0.03%]
利用真实世界数据识别帕金森病农民的暴露组预测因子以进行假设生成和机器学习的研究
Pascal Petit,François Berger,Vincent Bonneterre et al.
Pascal Petit et al.
BackgroundMachine learning offers new avenues for complementing traditional epidemiological approaches by analyzing routinely collected, population-based administrative health data.ObjectiveThis study aimed to identify potential exposomic p...
Burst deep brain stimulation for Parkinson's disease: A systematic review of efficacy and safety [0.03%]
帕金森病爆破式深部脑刺激疗效和安全性的系统评价
Martijn Hendriks,Matej Lokar,Hisse Arnts et al.
Martijn Hendriks et al.
BackgroundBurst deep brain stimulation (DBS) is a promising alternative to conventional deep brain stimulation (cDBS), incorporating paradigms such as theta burst stimulation (TBS), burst cycling (BC), and coordinated reset (CR). Findings f...
Full recovery after severe bacterial encephalitis and brain abscess following deep brain stimulation surgery for Parkinson's disease [0.03%]
帕金森病深部脑刺激手术后严重细菌性脑炎和脑脓肿完全恢复的一例报告
Eline Amy Rouleau,Debby Eic Falck,Carel Fe Hoffmann et al.
Eline Amy Rouleau et al.
Encephalitis and cerebral abscesses are rare, serious complications of deep brain stimulation (DBS) surgery. We report on two patients with Parkinson's disease (PD) who developed a critical condition with focal neurological symptoms and dec...