Julita Chlebowicz,Violetta Ivanova,Jacqueline Burré
Julita Chlebowicz
Parkinson's disease (PD) is characterized by progressive motor and non-motor dysfunction arising from synaptic pathology that precedes neuronal loss. Synaptic dysfunction represents a central pathological mechanism in both familial and spor...
Early bone health assessment is indicated in Parkinson's: Risk factor analysis in a UK population-based cohort study [0.03%]
基于英国人群的队列研究提示应早期评估帕金森病患者的骨骼健康：危险因素分析
Sacha E Gandhi,Katherine A Grosset,Prasanth A Iruthayaraj et al.
Sacha E Gandhi et al.
BackgroundOsteoporosis and major osteoporotic fracture are more common in PD than controls, but evaluation of sociodemographic factors and preventive treatment is limited.MethodsIn a UK population-based nested case-control study, incidence ...
Cultural and systemic barriers in Parkinson's disease diagnosis, treatment, and research participation among Asian Americans: A qualitative study [0.03%]
美国亚裔帕金森病诊断、治疗和研究参与的文化和体制障碍：一项定性研究
Preston Dang,Ziyue Luo,Xiecheng Chen et al.
Preston Dang et al.
IntroductionDespite being the fastest-growing ethnic group in the United States, Asian Americans, encompassing all ethnic subgroups, remain notably underrepresented in Parkinson's Disease (PD) research and clinical trials. This qualitative ...
Creation of a machine learning-based model for early identification of mild cognitive impairment risk in Parkinson's disease: A PD research center-based population study [0.03%]
基于机器学习模型的帕金森病轻度认知障碍风险早期识别研究：PD研究中心人群队列研究报告
Zhengting Yang,Sufang Liu,Li Wang et al.
Zhengting Yang et al.
BackgroundThis study aimed to use data from the PD-MDCNC database to develop a risk prediction model using machine learning (ML) methods for the early identification of the risk of mild cognitive impairment in Parkinson's disease (PD-MCI) w...
Insights and priorities from the 2025 private funders' Parkinson's disease and related disorders large footprint data interoperability summit [0.03%]
2025年帕金森病和相关障碍大型基金资助者数据互操作性峰会的见解和优先事项
Leslie C Kirsch,Emily Baxi,Mukta Phatak et al.
Leslie C Kirsch et al.
Effective sharing of large datasets across traditionally siloed research domains has the power to transform conventional research practice dramatically, but has been stymied by persistent barriers to data access and interoperability. The 20...
A modified Delphi consensus study to support and enhance Parkinson's disease management [0.03%]
一项改良德尔菲共识研究助力帕金森病的诊疗与管理
N Pavese,J Evans,A Hand et al.
N Pavese et al.
BackgroundLevodopa is still the cornerstone of symptomatic treatment for people with Parkinson's disease (PwP). With disease progression and long-term use, PwP can develop motor complications such as wearing off and dyskinesia. There is lim...
Commentary: Pesticides and GBA1 pathogenic variants in Parkinson's disease: An emerging and potentially dangerous association [0.03%]
评论：农药和GBA1致病突变在帕金森病中的关联：一个新兴且潜在危险的组合
Artur Fs Schuh,Leonidas Stefanis
Artur Fs Schuh
We comment here on the recently published paper by Ostentag et al., 2026, which examined self-reported environmental exposures in a group of patients with Parkinson's Disease (PD). Patients with GBA1-associated Parkinson's Disease (PD) were...
High intensity interval training for Parkinson's disease: A scoping review of systemic effects and physiological adaptations [0.03%]
高强度间歇训练对帕金森病系统性影响及生理适应性的概述性综述
Anjali Sivaramakrishnan,Meenal Cascella,Samantha Hauck et al.
Anjali Sivaramakrishnan et al.
BackgroundHigh intensity interval training (HIIT) involves vigorous intensity exercise bouts interspersed with low intensity bouts. Despite growing interest, the optimal dosage and clinical adaptability of HIIT in Parkinson's disease (PD) r...
When caution becomes neglect: Deep brain stimulation and cognitive impairment in Parkinson's disease [0.03%]
当谨慎变成疏忽：帕金森病的深部脑刺激与认知障碍
Simon Jg Lewis
Simon Jg Lewis
Over the past 25 years, a prevailing clinical dogma has held that significant cognitive impairment constitutes a contraindication to the use of Deep Brain Stimulation in Parkinson's disease. Whilst multiple studies, excluding such patients,...
Longitudinal change in swallow function in patients with Parkinson's disease (PD) [0.03%]
帕金森病(PD)患者吞咽功能的纵向变化
Camryn R Marshall,VyVy N Young,Zoe Weston et al.
Camryn R Marshall et al.
ObjectiveParkinson's disease (PD) frequently involves dysphagia, yet real-world longitudinal data capturing its progression and response to clinical care remain limited. Most prior studies exclude treated patients or rely solely on subjecti...