Analysis of α-synuclein seed amplification assay in carriers of GBA1 and LRRK2 pathogenic variants [0.03%]
GBA1和LRRK2致病突变携带者中α-突触核蛋白种子增殖检测的分析
Kyle B Fraser,Anat Mirelman,Omar S Mabrouk et al.
Kyle B Fraser et al.
BackgroundThe α-synuclein seed amplification assay (αS-SAA) represents a promising strategy for identifying individuals with α-synuclein pathology, empowering development of tailored Parkinson's disease (PD) therapeutics and clinical tri...
Serum phosphorylated tau 217 in GBA1 variant carriers with and without Parkinson disease [0.03%]
GBA1变异携带者中和不携带帕金森病患者的血清磷酸tau 217蛋白质水平
Elisa Menozzi,Roxana Mezabrovschi,Aleesa Nazeer et al.
Elisa Menozzi et al.
It is unclear whether Alzheimer disease pathology drives cognitive decline in Parkinson disease (PD) patients carrying GBA1 variants. We evaluated levels of serum phosphorylated tau 217 (p-tau217) in samples from 29 GBA1-PD, 32 idiopathic P...
Dual-Risk axis: GBA1 mutations and occupational pesticide exposure in Parkinson's disease [0.03%]
GBA1突变和职业农药暴露与帕金森病的关系
Zeynep Hilal Üstündağ,Hazal Özçelik,Ipek Koker et al.
Zeynep Hilal Üstündağ et al.
BackgroundOccupational pesticide (OcP) exposure and pathogenic GBA1 variants are established risk factors for Parkinson's disease (PD). However, whether they interact to influence disease onset or severity remains uncertain.ObjectiveTo dete...
The road for developing new pharmacological therapies for Parkinson's disease: Current trends and targets in clinical trials [0.03%]
帕金森病新药研发之路：临床试验的现状与趋势及靶点
Tiago Machado,Gonçalo S Duarte,Tiago F Outeiro et al.
Tiago Machado et al.
BackgroundDespite substantial research efforts, advances in Parkinson's disease therapeutics remain largely confined to the management of motor symptoms, with comparatively limited progress in addressing non-motor features, and with no prov...
Anxiety is associated with increased risk of suicidality in Parkinson's disease [0.03%]
焦虑与帕金森病自杀风险增加有关
Joyce St Lam,Kira N Tosefsky,Julie Zhu et al.
Joyce St Lam et al.
BackgroundSuicide risk in Parkinson's disease (PD) remains understudied, with limited exploration of the impact of neuropsychiatric comorbidities and commonly prescribed PD and psychiatric medications.ObjectiveTo investigate the prevalence ...
Consensus expert recommendations for management of dysphagia during hospital admission in Parkinson's disease [0.03%]
帕金森病住院患者的吞咽困难管理专家共识建议
Delaram Safarpour,Annie Brooks,Adrianne Smiley et al.
Delaram Safarpour et al.
Dysphagia is a common and often underrecognized symptom in patients with Parkinson's disease (PD) that is frequently overlooked during hospitalization. Dysphagia may be present without overt clinical signs, complicating timely identificatio...
An online platform to increase access to gait rehabilitation for underserved Parkinson's disease communities [0.03%]
一个在线平台 增加服务不足的帕金森病社区步行康复的渠道
Tamine Tc Capato,Anouk Tosserams,Bastiaan R Bloem et al.
Tamine Tc Capato et al.
Compensation strategies are a key element of gait rehabilitation in Parkinson's disease, ideally requiring involvement of specialized therapists. However, access to allied healthcare is not universally guaranteed. We evaluated an online pla...
Discrepancies between patient and caregiver reports of daily living abilities in Parkinson's disease [0.03%]
帕金森病患者和护工日常生活能力报告的一致性研究
Bora Jin,Sang-Myung Cheon
Bora Jin
BackgroundPatients with Parkinson's disease (PD) frequently experience a progressive decline in their activities of daily living (ADL), necessitating caregiver support. Discrepancies between patient and caregiver ADL ratings are common and ...
The future of clinical trials? Monitoring mobility as an outcome measure in Parkinson's disease: The mobilise-D study [0.03%]
帕金森病临床试验的未来？作为结局指标的移动性监测：mobilise-D研究
Alison J Yarnall,Lisa Alcock,Christian Schlenstedt et al.
Alison J Yarnall et al.
BackgroundA key challenge in trials targeting disease modification in Parkinson's disease (PD) is the lack of sensitive, precise, and patient-relevant outcome measures. Digital mobility outcomes (DMOs), captured using body-worn devices, off...
Self-delivered arousal-heightening stimuli to improve mobility in persons with parkinsonism: A case series [0.03%]
自我递送增强快感的刺激物以改善帕金森氏症患者的行动能力：一系列病例研究
Gijs Vissers,Anouk Tosserams,Bastiaan R Bloem et al.
Gijs Vissers et al.
Classic accounts of 'kinesia paradoxa' typically involve highly stressful or life-threatening situations, which are difficult to translate to daily life. Here, we describe two patients with parkinsonism who successfully apply self-induced '...