Patients with small fiber neuropathy exhibit more pronounced non-motor symptoms in Parkinson's disease [0.03%]
小纤维神经病患者帕金森病的非运动症状更明显
Chunge Xie,Jieling Chen,Rong Gan et al.
Chunge Xie et al.
BackgroundPeripheral neuropathy in Parkinson's disease (PD) may not be an isolated pathological phenomenon but may interact with other non-motor symptoms.ObjectiveTo conduct a comprehensive investigation of the non-motor symptoms observed i...
Motor features that distinguish isolated REM sleep behavior disorder patients from healthy controls: A systematic review [0.03%]
与健康对照相比，异动特征可区分快速眼动睡眠行为障碍患者：系统评价
Salma Elasfar,Hajr Hameed,Kaylena Ehgoetz Martens
Salma Elasfar
Individuals with isolated REM sleep behavior disorder (iRBD) are at high risk of developing α-synucleinopathies, particularly Parkinson's disease (PD) and dementia with Lewy bodies (DLB). With the development of potential neuroprotective t...
In situ exogenous alpha-synuclein aggregates inhibit murine ventricular voltage-gated inward sodium and outward potassium currents [0.03%]
外源性α-突触核蛋白原位聚集抑制小鼠心室电压门控内向钠电流和外向钾电流
Bonn Lee,Shiraz Ahmad,Charlotte E Edling et al.
Bonn Lee et al.
BackgroundAlpha-synuclein is associated with neurodegeneration in Parkinson's disease (PD). Recent studies have increasingly recognized incidences of cardiac complaints in PD patients. In particular, the occurrence of arrhythmias in PD pati...
Peripheral inflammatory markers and clinical phenotypes reflecting the impact of diabetes on Parkinson's disease [0.03%]
糖尿病对帕金森病的影响的外周炎症标志物和临床表型反射
In Hee Kwak,Hyeo-Il Ma,Yun Joong Kim et al.
In Hee Kwak et al.
BackgroundType 2 diabetes mellitus (DM) can influence the phenotype and progression of Parkinson's disease (PD), as both conditions share inflammation as a common pathogenic mechanism.ObjectiveTo explore peripheral inflammatory indices that...
Kevin McFarthing,Tiago Fleming Outeiro,Maria Carmo Bastos
Kevin McFarthing
Parkinson's disease (PD) is a heterogeneous condition that presents variable clinical, neuropathological, and biomarker features. Disease progression can also vary significantly. It is essential to consider this heterogeneity when consideri...
Do we need drugs for psychiatric symptoms specifically for Parkinson's disease? [0.03%]
我们有必要使用针对帕金森病精神症状的药物吗？
Kelly A Mills,Gregory M Pontone
Kelly A Mills
Although the need for better medications for the treatment of psychiatric symptoms in people with Parkinson's disease (PWP) is not disputed, the approach and targets for these medications needs further attention. Psychiatric symptoms occur ...
Platelet mitochondrial complex I and IV activities are not reliable stratification biomarkers in Parkinson's disease [0.03%]
血小板线粒体复合物I和IV活性不是帕金森病的可靠分层生物标志物
Simon Ulvenes Kverneng,Sepideh Mostafavi,Yana Mikhaleva et al.
Simon Ulvenes Kverneng et al.
BackgroundMitochondrial dysfunction, particularly complex I (CI) deficiency, is considered an integral feature of Parkinson's disease (PD). However, recent findings indicate that widespread neuronal CI deficiency in the brain is only presen...
Cortical thickness alterations in Parkinson's disease related anxiety: A cross-sectional 7 T MRI study [0.03%]
帕金森病相关焦虑的皮层厚度改变：一项7T磁共振成像横断面研究
Michiel van Lier,Guillaume Carey,Romain Viard et al.
Michiel van Lier et al.
BackgroundAnxiety is a common non-motor symptom in Parkinson's disease (PD) and has previously been associated with changes in cortical thickness of various brain regions.ObjectiveTo identify changes in cortical thickness in PD-related anxi...
Body mass index, metabolically abnormal status, and incident Parkinson's disease: Data from the UK Biobank [0.03%]
体质指数、代谢异常状态与帕金森病的发病风险：来自英国生物样本库的数据分析
Hae-Ryong Yun,Nak-Hoon Son,Hee Byung Koh et al.
Hae-Ryong Yun et al.
BackgroundThe association between body mass index (BMI), metabolic conditions, and incident Parkinson's disease (PD) is quite complex.ObjectiveTo investigate the relationship between these variables, particularly the impact of metabolically...
A dose-finding study shows terazosin enhanced energy metabolism in neurologically healthy adults [0.03%]
一项剂量研究显示特拉唑辛可增强神经学健康成人能量代谢
Jordan L Schultz,Phillip E Gander,Craig D Workman et al.
Jordan L Schultz et al.
BackgroundParkinson's disease (PD) is a common neurodegenerative disease lacking treatments that modify progressive neuron loss. Terazosin (TZ) increases activity of the glycolytic enzyme phosphoglycerate kinase 1 and could potentially bene...