'Pathology is disease' Parkinson's mythology: The 'brain-first-body-first' case study [0.03%]
“病理即疾病”的帕金森病神话——一例“脑先躯体后”病例研究报告
Alberto J Espay,Andrew J Lees
Alberto J Espay
Beyond protocol standardization: The importance of data curation and software transparency [0.03%]
超越协议标准：数据管理和软件透明度的重要性
Julius Welzel,Nadine Jacobsen,Helena Cockx et al.
Julius Welzel et al.
Mancini et al.'s framework for gait assessment in Parkinson's disease (PD) is a valuable contribution, enabling a harmonization of study protocols in this research field and, consequently, a substantial improvement of data interpretation ac...
Apathy linked to higher amyloid burden and cognitive deterioration in Parkinson's disease [0.03%]
帕金森病患者的冷漠与淀粉样蛋白负荷增加及认知衰退有关
Carmen Gasca-Salas,Roberto Fernández-Fernández,Rafael Rodríguez-Rojas et al.
Carmen Gasca-Salas et al.
BackgroundApathy, defined as a quantitative reduction in goal-directed activity, is a non-motor manifestation that can be present in Parkinson's disease (PD). It seems to be a risk factor for conversion to dementia (PDD) in this population....
Gut microbial shifts toward inflammation in Parkinson's disease: Insights from pilot shotgun metagenomics Egyptian cohort [0.03%]
帕金森病向炎症转变的肠道微生物群转移：来自埃及队列试点鸟枪法宏基因组学研究的新见解
Ali Shalash,Shahd Ezzeldin,Sara Hashish et al.
Ali Shalash et al.
Gut microbiome alterations are increasingly linked to Parkinson's disease (PD), yet regional signatures remain underexplored. We performed shotgun metagenomic sequencing of stool samples from Egyptian PD patients and healthy controls. PD pa...
Atypical parkinsonian syndromes in French Guiana: Similarities and differences with Caribbean variants [0.03%]
法属圭亚那的非典型帕金森综合征与加勒比地区变异类型的异同点
Amina Nasri,Hugo Chaumont,Souraya Arnaud et al.
Amina Nasri et al.
BackgroundAtypical parkinsonian syndromes are highly prevalent in the French West Indies (FWI), making up 70% of degenerative parkinsonisms and including "Caribbean Atypical Parkinsonism". Environmental neurotoxins from Annonaceae plants ar...
Differences in intestinal microbiota in Parkinson's disease and isolated REM sleep behavior disorder [0.03%]
帕金森病与孤立性快速动眼睡眠行为异常的肠道菌群差异
Alba Troci,Julienne Haas,Anna Weiß et al.
Alba Troci et al.
Previous studies have shown differences in the microbiota of patients with Parkinson's disease (PD) compared to healthy controls (HC). To deduce a possible causality, it is highly relevant to examine changes in the prodromal phase. This stu...
Blood and cerebrospinal fluid metallomics uncover mercury, chromium, and iron alterations in de novo Parkinson's disease [0.03%]
血清和脑脊液金属组揭示特发性帕金森病患者的汞、铬和铁异常
Petr Dušek,Ranjani Ganapathy Subramanian,Tereza Serranová et al.
Petr Dušek et al.
BackgroundGiven the increasing global prevalence of Parkinson's disease (PD) and its complex etiopathogenesis, understanding the role of environmental factors is crucial. Prior investigations suggested a potential link between metal exposur...
Faster disease progression in Parkinson's disease with glucocerebrosidase genotype: But not apparent immediate from diagnosis [0.03%]
帕金森病患者中的葡糖脑苷脂酶基因型与更快的疾病进展：但不能在确诊时立即显现出来
Henrieke L Frequin,Bart Ferwerda,Constant Vm Verschuur et al.
Henrieke L Frequin et al.
BackgroundThis study presents post-hoc analyses of the LEAP study focusing on disease progression in patients with early Parkinson's disease (PD) who either have a glucocerebrosidase gene (GBA1) mutation (GBA1mut) or do not have a mutation ...
Pathophysiology and pharmacological management for sleep problems in Parkinson's disease [0.03%]
帕金森病的睡眠问题的发生机制及药物管理措施
Cristian Falup-Pecurariu,Larisa Ungureanu,Iulia Murasan et al.
Cristian Falup-Pecurariu et al.
Sleep problems are among the most frequently reported non-motor symptoms of Parkinson's disease (PD), with a broad range of disorders: insomnia, REM sleep behavior disorder, restless legs syndrome, excessive daytime sleepiness, and sleep-re...
A glimpse of the end-of-life of people with Parkinson's disease and atypical parkinsonism: A descriptive analysis of electronic health records [0.03%]
帕金森病和非典型帕金森综合征患者临终阶段的一瞥——电子健康记录描述性分析
Herma Lennaerts-Kats,Anke Elbers,Catharina Muente et al.
Herma Lennaerts-Kats et al.
BackgroundThe needs of people with Parkinson's disease (PD) or atypical parkinsonism (AP) change significantly in the final weeks to days of life. A better understanding of this phase can help improve care.ObjectiveTo examine healthcare use...