Relating movement behaviours and non-motor characteristics in people with Parkinson's disease: A compositional data analysis approach [0.03%]
帕金森病患者的运动行为和非运动特征的相关性：一种组成数据方法
Kristina Larsson,Hanna Johansson,Daniel Peterson et al.
Kristina Larsson et al.
BackgroundPeople with Parkinson's disease (PwPD) have unhealthier movement behaviours (less moderate-to-vigorous physical activity (MVPA) and more sedentary behaviour (SB)), than healthy older adults. Associations across movement patterns a...
Parkinson's disease participant-led research: Towards neuroimaging-assisted deep brain stimulation programming [0.03%]
帕金森病患者的主导研究：向神经影像辅助的深部脑刺激编程发展
Mark D McAuley,Alena A Ionova,Andreas Horn et al.
Mark D McAuley et al.
Deep brain stimulation (DBS) can improve Parkinson's disease symptoms; however, its effectiveness depends on selecting optimal settings. DBS parameter selection can be challenging, as objective metrics to guide the process are lacking. This...
PARKinSOUND: Impact of participation in an orchestra in patients with Parkinson's disease [0.03%]
PARKinSOUND：参与乐团对帕金森病患者的影响
Sofia Lopes,Sofia Marques,Andreia Ferreira et al.
Sofia Lopes et al.
Music therapy has emerged as a promising complementary intervention for Parkinson's disease (PD). PARKinSOUND, a non-randomized clinical trial, evaluated the feasibility of a community orchestra intervention for individuals with PD (n = 22)...
Quantitative measurements of α-synuclein seeds in CSF inform diagnosis of synucleinopathies [0.03%]
定量测量α-突触核蛋白种子在CSF中的信息告知Tau病的诊断
Ilham Y Abdi,Indulekha P Sudhakaran,Simona S Ghanem et al.
Ilham Y Abdi et al.
Diagnosing α-synucleinopathies and assessing target engagement in trials is hindered by the lack of reliable biomarkers. Here, we introduce a first-in-kind quantitative, highly sensitive, and disease-specific diagnostic assay, named Seedin...
Samuel Yong-Ern Ng,Darakhshan Naheed,Ehsan Seyed Saffari et al.
Samuel Yong-Ern Ng et al.
Physical activity (PA) remains critical in the slowing of disease progression in early Parkinson's disease (PD), although the longitudinal follow-up of such studies remain scarce. Using data from an early PD Cohort, we longitudinally examin...
Prevention of cognitive impairment and dementia in people with Parkinson's disease: A call-to-action [0.03%]
呼吁行动预防帕金森病患者的认知障碍和痴呆症
Elke Kalbe,Tobias Warnecke,Carsten Eggers et al.
Elke Kalbe et al.
Mild cognitive impairment and dementia are common symptoms in people with Parkinson's disease (PwPD) that impair the quality of life of those affected. However, PD-specific concepts for the prevention of cognitive decline are rarely incorpo...
Surface electromyographic profiles during gait initiation in people with Parkinson's disease: The effects of external sensory cueing [0.03%]
帕金森病患者步行启动时的表面肌电图特征：外部感觉提示的作用
Lesley A Perg,Chiahao Lu,Matthew N Petrucci et al.
Lesley A Perg et al.
BackgroundImpaired gait initiation is a debilitating motor symptom in people with Parkinson's disease (PD). During self-paced (uncued) gait initiation, anticipatory postural adjustments (APAs) are often absent or attenuated, and the first s...
Advice to people with Parkinson's in my clinic: How to manage running-induced dystonia [0.03%]
给我的门诊帕金森病患者的一些建议：如何应对运动诱发的肌张力障碍
Michele L Callisaya,Jane Alty,Dave de Groot et al.
Michele L Callisaya et al.
Exercise is an essential part of the treatment of Parkinson's disease. However, certain symptoms can make exercise difficult. In this viewpoint, we describe an under recognized symptom called running-induced dystonia (RID), which can preven...
Sidra Khan,Aparna Gupta,Aman Agarwal et al.
Sidra Khan et al.
Parkinson's disease (PD) is a rapidly developing neurodegenerative disorder characterized by degeneration of dopaminergic neurons in the basal ganglia of the brain. Its prevalence is estimated to exceed 1.2 million cases in the United State...
Obstructive sleep apnea, periodic limb movements, and REM sleep without atonia are common in Parkinson's disease and correlate with motor symptom burden [0.03%]
阻塞性睡眠呼吸暂停、周期性肢体运动和非去皮层化异相睡眠在帕金森病中很常见并与运动症状负担相关
Matteo Carpi,Mariangela Pierantozzi,Mariana Fernandes et al.
Matteo Carpi et al.
BackgroundSleep disturbances are prevalent and debilitating non-motor symptoms in patients with Parkinson's disease (PD).ObjectiveThis study aimed to explore sleep architecture and the prevalence of polysomnographic (PSG) sleep findings in ...