A modified Delphi study of post-operative management for subthalamic deep brain stimulation in Parkinson's disease [0.03%]
帕金森病丘脑底核深部电刺激术后管理专家共识(2019)
Anna J Pedrosa,Jan-Niklas Molter,Leonardo Brito de Almeida et al.
Anna J Pedrosa et al.
BackgroundDespite the widespread adoption of deep brain stimulation (DBS) for treating Parkinson's disease (PD) over the last few decades, standardized post-operative care protocols remain lacking.ObjectiveThis study aimed to establish expe...
Novel insights into relationships between metabolic covariance patterns of FDG-PET data and clinical status in Parkinson's disease using partial least squares correlation analysis [0.03%]
基于偏最小二乘相关分析的帕金森病FDG-PET代谢协方差模式及其与临床状态之间关系的新认识
Connor Wj Bevington,Sahib Dhaliwal,Jessamyn McKenzie et al.
Connor Wj Bevington et al.
IntroductionMetabolic covariance patterns derived from imaging data help characterize disease-related physiological changes in several neurodegenerative disorders, including Parkinson's disease (PD), but their relevance to different disease...
Inter-relationship of the age of onset to the concept of brain-first versus body-first Parkinson's disease [0.03%]
起病年龄与脑源性帕金森病和身体性帕金森病概念之间的相互关系
Leonidas Stefanis,Per Borghammer
Leonidas Stefanis
The subtyping of Parkinson's Disease (PD) into brain-first and body-first PD has a powerful neuropathological, neuroimaging and clinical basis, supported by most relevant subsequent studies that have examined its validity. Here, we put forw...
Sex differences in clinical and prognostic trajectories in patients with idiopathic REM sleep behavior disorder: Insights from the FARPRESTO cohort [0.03%]
特发性REM睡眠行为障碍患者的临床和预后轨迹的性别差异：来自FARPRESTO队列的启示
Michelangelo Maestri,Michela Figorilli,Federico Meloni et al.
Michelangelo Maestri et al.
IntroductionThere are conflicting findings regarding the influence of sex on idiopathic REM sleep behavior disorder (iRBD) in terms of prevalence and associated clinical characteristics. This study, conducted as part of the Italian multicen...
The impact of diet on Parkinson's disease risk: A data-driven analysis in a large Italian case-control population [0.03%]
饮食对帕金森病风险的影响：意大利大规模病例对照人群的基于数据的分析
Angelo Fabio Gigante,Barbara Vitucci,Vittorio Velucci et al.
Angelo Fabio Gigante et al.
BackgroundThe role of dietary factors as risk or protective factors for Parkinson's disease (PD) remains debated.ObjectiveThis retrospective case-control study aimed to evaluate the associations between foods identified through a data-drive...
When Parkinson's disease interferes in a couple's life: A qualitative study [0.03%]
帕金森病对夫妻生活的影响：定性研究
Kathy Dujardin,Charlotte Manceau,Emilie Wawrziczny et al.
Kathy Dujardin et al.
The present study aimed to provide an overview of the experiences of couples coping with Parkinson's disease (PD), along with a synthesis of the mechanisms involved in changes within the couple's relationship in the context of PD. These mec...
E Ray Dorsey,Michael S Okun,Bastiaan R Bloem
E Ray Dorsey
The Parkinson pandemic continues to spread. Almost 12 million individuals now have the disease, nearly double the estimate from just six years ago. Its human-made nature is also increasingly clear as more studies tie environmental toxicants...
Disturbed rest-activity rhythm in Parkinson's disease: Associations with motor severity and orthostatic hypotension [0.03%]
帕金森病中睡眠-活动节律异常与疾病严重程度及直立性低血压的关系研究
Manon D Mijnsbergen,Vasileios Exadaktylos,Jacobus J van Hilten et al.
Manon D Mijnsbergen et al.
BackgroundThe rest-activity rhythm (RAR) captures the distribution of rest and activity periods between and within days. Disturbed RAR has been observed in Parkinson's disease (PD), but the contribution of motor and non-motor symptoms to RA...
Managing fatigue in Parkinson's disease: Preparing for a randomized controlled trial [0.03%]
帕金森病疲劳的管理：随机对照试验的设计与实施准备阶段
Neda Alizadeh,Tanya Packer,Ingrid Sturkenboom et al.
Neda Alizadeh et al.
BackgroundFatigue in Parkinson's disease (PD) is a common, debilitating symptom often overlooked in research and clinical practice. Effective interventions are needed to mitigate its impact on people with PD.ObjectiveThis pilot study evalua...
Buspirone regulates cortico-striatal gamma oscillations to ameliorate dyskinesia [0.03%]
巴氯芬通过调节皮层-纹状体伽玛振荡来改善异动症症状
Han Liu,Ruizuo Wang,Yuming Xu et al.
Han Liu et al.
BackgroundLevodopa-induced dyskinesia (LID) in Parkinson's disease (PD) is linked to exaggerated gamma oscillations. Buspirone, a 5-HT1A receptor agonist, is a potent medication for psychiatric conditions, predominantly prescribed for anxie...