Impulse Control Disorders and Levodopa-Induced Dyskinesias in Parkinson's Disease: Pulsatile versus Continuous Dopaminergic Stimulation [0.03%]
帕金森病冲动控制障碍和左旋多巴诱发的运动障碍：脉冲给药与连续给药的对照研究
Simone Simoni,Federico Paolini Paoletti,Paolo Eusebi et al.
Simone Simoni et al.
Background: Dopaminergic medications in Parkinson's disease (PD) are usually associated with the development of both levodopa-induced dyskinesias (LID) and impulse control and repetitive behavior disorders (ICRB). ...
The Impact of the COVID-19 Pandemic on Parkinson's Disease: Hidden Sorrows and Emerging Opportunities [0.03%]
新冠肺炎疫情对帕金森病的影响：隐忧与机遇
Rick C Helmich,Bastiaan R Bloem
Rick C Helmich
Kevin McFarthing,Danielle Larson,Tanya Simuni
Kevin McFarthing
Innovative Recruitment Strategies to Increase Diversity of Participation in Parkinson's Disease Research: The Fox Insight Cohort Experience [0.03%]
帕金森病研究参与多样性的创新招募策略：Fox Insight队列的体验
Roseanne D Dobkin,Ninad Amondikar,Catherine Kopil et al.
Roseanne D Dobkin et al.
Background: Clinical research in Parkinson's disease (PD) faces practical and ethical challenges due to two interrelated problems: participant under-recruitment and lack of diversity. Fox Insight (FI) is a web-based longi...
Associations of Lower Caffeine Intake and Plasma Urate Levels with Idiopathic Parkinson's Disease in the Harvard Biomarkers Study [0.03%]
哈佛生物标志物研究中低咖啡因摄入量和血浆尿酸水平与特发性帕金森病的关联
Rachit Bakshi,Eric A Macklin,Albert Y Hung et al.
Rachit Bakshi et al.
Two purines, caffeine and urate, have been associated with a reduced risk of idiopathic Parkinson's disease (PD) in multiple cohorts and populations. The Harvard Biomarkers Study (HBS) is a longitudinal study designed to accelerate the disc...
The Dysfunctional Autonomic Function and "Dysfunctional" Fatigue in Drug Naïve Parkinson's Disease [0.03%]
药物治疗初诊帕金森病患者的自主神经功能异常及“异常”疲劳感
Jong Hyeon Ahn,Minkyeong Kim,Jun Kyu Mun et al.
Jong Hyeon Ahn et al.
Background: Fatigue is a common and disabling non-motor symptom in Parkinson's disease (PD). Autonomic dysfunction is suggested as the possible pathophysiology of fatigue, but it has not been investigated in drug-naïve P...
Plasma Metabolomic Markers of Insulin Resistance and Diabetes and Rate of Incident Parkinson's Disease [0.03%]
血浆代谢组标志物与帕金森病发病风险之间的关系研究
Samantha Molsberry,Kjetil Bjornevik,Katherine C Hughes et al.
Samantha Molsberry et al.
Background: Although there is evidence of shared dysregulated pathways between diabetes and Parkinson's disease, epidemiologic research on an association between the two diseases has produced inconsistent results. ...
Substantia Nigra Volume Dissociates Bradykinesia and Rigidity from Tremor in Parkinson's Disease: A 7 Tesla Imaging Study [0.03%]
帕金森病黑质体积与运动迟缓 rigidity 和震颤分离的的一项7特斯拉磁共振成像研究
Kathleen L Poston,Matthew A I Ua Cruadhlaoich,Laura F Santoso et al.
Kathleen L Poston et al.
Background: In postmortem analysis of late stage Parkinson's disease (PD) neuronal loss in the substantial nigra (SN) correlates with the antemortem severity of bradykinesia and rigidity, but not tremor. ...
The Impact of Deep Brain Stimulation on Sleep in Parkinson's Disease: An update [0.03%]
帕金森病的深部脑刺激对睡眠的影响：最新研究进展
José Rafael P Zuzuárregui,Jill L Ostrem
José Rafael P Zuzuárregui
Background: Parkinson's disease (PD) can have a significant impact on sleep. Deep brain stimulation (DBS) is an effective treatment for motor features of PD, but less is understood about the impact DBS may have on sleep a...
Antiparkinsonian Effects of a Metabotropic Glutamate Receptor 4 Agonist in MPTP-Treated Marmosets [0.03%]
metabotropic谷氨酸受体4激动剂在MPTP处理过的狨猴中的抗帕金森病作用
Elizabeth Mann,Michael Jackson,Louise Lincoln et al.
Elizabeth Mann et al.
Background: Increased firing across glutamatergic synapses may contribute to both the motor dysfunction and L-DOPA-induced dyskinesia seen in Parkinson's disease. Given their ability to reduce glutamate release, activatio...