The Parkinson's Universe: A person-centered care model for Parkinson's disease [0.03%]
属于帕金森患者的宇宙：帕金森病的以患者为中心的护理模型
Michael S Okun,Bastiaan R Bloem,E Ray Dorsey
Michael S Okun
Parkinson's disease is the fastest growing neurodegenerative disorder worldwide, yet care delivery remains fragmented and inequitable. We propose a new construct called the Parkinson's Universe. It is a person-centered model that reimagines...
MRI susceptibility map weighted imaging (SMWI) as a neurodegeneration biomarker in the prodromal to overt alpha-synucleinopathy continuum [0.03%]
多巴胺能轴损伤的磁共振成像易损性图谱加权成像在其前驱期到显临床期的演变中的作用
Laura Falcitano,Francesco Calizzano,Pietro Mattioli et al.
Laura Falcitano et al.
Background and objectiveNigrostriatal dopaminergic degeneration is commonly assessed using dopamine transporter (DaT) SPECT. Iron sensitive MRI is a promising technique to assess substantia nigra, yet few studies explored its application in...
Evaluation and management of male sexual dysfunction in Parkinson's disease: A clinical road map [0.03%]
帕金森病男性性功能障碍的评估与管理：临床操作指南
Anessa N Rafetto,Gillian R Murray,Matthew J Ziegelmann
Anessa N Rafetto
Parkinson's disease (PD) is a progressive neurodegenerative disease with multiple manifestations including both motor and non-motor symptoms. One manifestation of PD that is often overlooked is the sexual dysfunction (SD) that patients may ...
Saeed Kayhanian,Roger A Barker
Saeed Kayhanian
Parkinson's disease is a common neurodegenerative disorder, which is characterised by motor features, many of which relate to the loss of the dopaminergic nigrostriatal pathway. The use of grafted cells to replace the lost dopaminergic neur...
Mucuna pruriens in untreated Parkinson's disease in sub-Saharan Africa: A 12-month, multicenter, randomized, controlled trial [0.03%]
非洲撒哈拉以南地区未经治疗的帕金森病患者服用 Mucuna pruriens 的疗效：一项为期 12 个月的多中心随机对照试验
Roberto Cilia,Momodou Cham,Vida Obese et al.
Roberto Cilia et al.
BackgroundParkinson's disease (PD) causes disability and premature mortality if untreated. Limited access to levodopa in low- and middle-income countries leaves many patients undertreated. Mucuna pruriens (MP) is a leguminous plant that con...
Association of dopamine depletion and cholinergic basal forebrain atrophy with brain metabolism and cognition in Parkinson's disease [0.03%]
帕金森病患者多巴胺能神经元脱失、胆碱能基底节变性与脑代谢及认知之间的关系
Jung Hyun Lee,Mina Park,Sung Jun Ahn et al.
Jung Hyun Lee et al.
BackgroundCognitive dysfunction is one of the most debilitating non-motor symptoms of Parkinson's disease (PD). This study aimed to explore the interplay between altered neurotransmitter activities, including dopamine and acetylcholine, and...
Daily steps and health outcomes: Implications for persons with Parkinson's disease [0.03%]
步数与健康结局：帕金森病患者的含义
Thomas H Oosterhof,Bastiaan R Bloem,Nienke M de Vries et al.
Thomas H Oosterhof et al.
Reactive astrocyte-related pathogenic genes in Parkinson's disease: A multi-omics Mendelian randomization study [0.03%]
帕金森病中与反应性星形胶质细胞相关的致病基因：一种多组学孟德尔随机化研究
Huixi Wang,Jiahao Hu,Bin Mo et al.
Huixi Wang et al.
BackgroundReactive astrocytes are one of the pathological features of Parkinson's disease (PD) and are associated with neuroinflammation and neuronal damage.ObjectiveTo explore the causal relationship between reactive astrocyte-related gene...
Fear of progression in Parkinson's disease: Role of age and occupational status [0.03%]
帕金森病进展的恐惧：年龄和职业状态的作用
Simone D&#x;Souza,Esther Tekampe,Björn Falkenburger et al.
Simone D&#x;Souza et al.
Background: Parkinson's disease (PD) is a slowly progressing neurodegenerative disorder, so it is likely that people with PD (PwPD) face increasing disability. PwPD thus experience various degrees of fear of progression (FoP), which can bec...
Seeds of hope: Mucuna Pruriens offers promise for persons with Parkinson's disease in Africa [0.03%]
希望的种子：Mucuna Pruriens为非洲帕金森病患者带来福音
Nicola Modugno,Natasha Fothergill-Misbah
Nicola Modugno