Candidate biomarkers for early Giardia duodenalis infection revealed by time-resolved secretome proteomics [0.03%]
时间分辨分泌组蛋白质组学揭示的早期空肠弯曲杆菌感染候选生物标志物
Bo Li,Xi Chen,Linfan Zhang et al.
Bo Li et al.
Giardia duodenalis is a zoonotic protozoan parasite that causes giardiasis in humans and other mammals. Early diagnosis remains challenging because current diagnostic methods, including microscopy and enzyme-linked immunosorbent assays (ELI...
Ibon Iloro,Coralia Perez,Jabi Beaskoetxea et al.
Ibon Iloro et al.
The combination of genetic accessibility, organ complexity, evolutionary conservation, and cost-efficiency makes Drosophila melanogaster (Dm) a well-known model system for biomedical and fundamental biological research. Proteomic analysis o...
Giuseppe Palmisano,Fábio César Sousa Nogueira,Fabio Cesar Gozzo et al.
Giuseppe Palmisano et al.
Integrated salivary proteomic and metabolomic analyses reveal molecular characterization and novel biomarker panels of chronic obstructive pulmonary disease [0.03%]
整合分析揭示慢性阻塞性肺疾病的分子特征及新型生物标志物组合
Hangming Xiong,Yingying Xue,Xiaojing Zhang et al.
Hangming Xiong et al.
Chronic obstructive pulmonary disease (COPD) is a respiratory disorder characterized by chronic inflammation, oxidative stress, and metabolic dysregulation. The lack of convenient and easily-accessible non-invasive diagnostic approaches rem...
S Wislet,C Le Goff,Ph Massonet et al.
S Wislet et al.
Background: Sweat is increasingly recognized as a valuable, non-invasive biofluid for biomarker discovery, yet its composition depends on the stimulation method. This study aimed to determine how pharmacological induction...
Community-driven advances in computational mass spectrometry: The perspective of EuBIC-MS members [0.03%]
社区驱动的计算质谱法进展：来自EuBIC-MS成员的观点
Dirk Winkelhardt,Julia P Schessner,Sven Berres et al.
Dirk Winkelhardt et al.
Advances in data acquisition, artificial intelligence, and integrative bioinformatics are driving the rapid evolution of computational mass spectrometry, and in turn, transforming modern proteomics, metabolomics, and lipidomics. These devel...
Proteome-level evidence that tebuconazole, both alone and in interaction with thiacloprid, affects epigenetic events in bumblebee heads [0.03%]
灭虫真菌唑及其与噻虫啉互作影响大黄蜂头部表观遗传事件的蛋白质组学证据
Elena Shcherbachenko,Apostolos Pekas,Martin Markovic et al.
Elena Shcherbachenko et al.
Tebuconazole, a widely used ergosterol biosynthesis-inhibiting fungicide, can affect nontargets, especially when combined with insecticides. We employed label-free quantitative proteomics to investigate the effects of long-term exposure to ...
Proteomics-based analysis of the defense mechanisms of disease-resistant grass carp against Aeromonas veronii [0.03%]
基质辅助激光解析电离飞行时间质谱技术分析草鱼抗致病气单胞菌的防御机制
Shiyi Zhou,Huimin Gan,Chunxue Gu et al.
Shiyi Zhou et al.
Sustainable aquaculture of grass carp (Ctenopharyngodon idella, GC) is consistently threatened by bacterial diseases, particularly those caused by Aeromonas veronii. A disease-resistant grass carp (DR-GC) has been developed by backcrossing ...
On-filter fractionation by empFASP improves identification of membrane peptides in proteomic experiments [0.03%]
使用empFASP滤膜分段法可提高蛋白质组学实验中跨膜肽段的鉴定率
Jana Březinová,Adéla Pravdová,Michal Korecký et al.
Jana Březinová et al.
Membrane proteins remain among the most analytically challenging targets in bottom-up proteomics due to their limited solubility and low abundance of protease-accessible sites within transmembrane domains. In addition, hydrophobic peptides ...
Transpulmonary proteomic gradient analysis in women with pulmonary arterial hypertension associated with systemic sclerosis [0.03%]
与系统性硬化症相关的肺动脉高压女性患者的跨肺蛋白质组梯度分析
Manuel Teixeira,David Sá Couto,Maria Isilda Oliveira et al.
Manuel Teixeira et al.
This study investigated proteomic alterations in the pulmonary circulation of patients with pulmonary arterial hypertension associated with systemic sclerosis (PAH-SSc) by analyzing the transpulmonary protein gradient and comparing the prot...