Proteomics at scale: Bottlenecks and opportunities for early-career researchers in a fast developing field [0.03%]
大规模蛋白质组学：快速发展的领域中早期职业研究人员面临的瓶颈和机遇
Marie Chion,Michele Costanzo,Marie Gebelin et al.
Marie Chion et al.
The field of proteomics has rapidly evolved over the last five years enabled by rapid advances in instrumentation and computation. At the same time, the proteomics community is also growing. This is reflected by the increasing participation...
Guard cell-enriched phosphoproteome reveals phosphorylation of endomembrane proteins in closed stomata [0.03%]
护细胞富集磷蛋白组揭示闭合气孔内膜蛋白磷酸化现象
Anne-Marie Pullen,Scott P Lyons,Angie L Mordant et al.
Anne-Marie Pullen et al.
Control of the stomatal aperture is multifaceted, involving a complex interplay of environmental cues and intracellular signaling pathways. It is well established that changes in ion gradients drive water movement into and out of the guard ...
Sarah A Konze,Julia Beimdiek,Astrid Oberbeck et al.
Sarah A Konze et al.
Human pluripotent stem cells can be differentiated into a variety of different cell types, for instance cardiomyocytes. Especially in the context of future application in regenerative medicine, it is crucial to understand the developmental ...
Standardizing tear proteomics preanalytics: Capillary vs Schirmer sampling and denaturing vs mild elution buffers shape proteome depth and abundance profiles [0.03%]
泪液蛋白质组预分析标准化：毛细血管与Schirmer取样及变性与温和洗脱缓冲液对蛋白质组深度和丰度的影响
Isabel Cerro-Pardo,Amaiur Mendizabal,Mikel Azkargorta et al.
Isabel Cerro-Pardo et al.
Tear fluid is a promising minimally invasive source of biomarkers for ocular surface diseases (OSDs). However, variability in sampling and pre-analytical processing remains a major limitation for reproducibility and cross-study comparabilit...
Integrated analysis of transcriptomes and proteomes reveals the molecular mechanisms underlying the development of Dorper sheep hair follicles [0.03%]
转录组和蛋白质组联合分析揭示杜泊羊毛囊发育的分子机制
Siyu Wang,Ningyue Zhang,Chunguang Wang et al.
Siyu Wang et al.
Understanding the molecular mechanisms underlying normal hair follicle development is important for improving wool traits in sheep and skin traits in mammals. This study aims to investigate the genetic determinants influencing hair follicle...
Comparative peptidomics of four wasp venoms reveals extensive peptide diversity, proteolytic patterns, and predicted bioactivities [0.03%]
四种黄蜂毒液的比较肽组学揭示了广泛的肽多样性、蛋白酶模式和预测生物活性
Kai Wang,Jiangtao Qiao,Loïc Quinton et al.
Kai Wang et al.
Wasp venoms possess complex compositions and diverse bioactivities, making them potential pharmacological sources. In this study, venoms from four wasp species (Vespa mandarinia, V. velutina, V. basalis, and Provespa barthelemyi) were colle...
Cosine similarity analysis of venom proteomes of Indian cobras, Naja naja and Naja kaouthia reveals significant interspecies and geographic variations [0.03%]
印度 Cobra 毒液蛋白质组的余弦相似性分析显示种间和地理差异显著
Sneha Bansode,Kruti Modi,Sana Ziya et al.
Sneha Bansode et al.
The Indian cobra (genus Naja) is one of the 'Big Fours' responsible for dreaded snakebite incidents in India. Immediate anti-snake venom (ASV) treatment is the only solution for cobra envenomation. Currently available ASVs are not efficacio...
Machine learning-enhanced plasma proteomics discriminates pancreatic cancer-associated diabetes from type 2 diabetes mellitus [0.03%]
机器学习增强的血浆蛋白质组学可区分与胰腺癌相关的糖尿病和2型糖尿病
Lucas Cardoso Lazari,Carlos Del Cistia Donnarumma,Luiz Henrique Gomes Matheus et al.
Lucas Cardoso Lazari et al.
Pancreatic ductal adenocarcinoma (PDAC) is frequently preceded by new-onset diabetes mellitus (NODM), yet differentiating PDAC-associated DM from type 2 diabetes (T2D) remains clinically challenging. We investigated whether plasma proteomic...
Functional and protein interaction analysis of Nop7 in trypanosomatid parasites [0.03%]
沙眼衣原体Nop7的功能和蛋白质相互作用分析
Tomás Nepomuceno-Mejía,Laila Espinosa-Renteria,Aldo Yael Miranda-Muñoz et al.
Tomás Nepomuceno-Mejía et al.
Nucleolar protein 7 (Nop7), also known as PES1 or Pescadillo, is a conserved factor essential for ribosome biogenesis, cell cycle progression, proliferation, and nucleolar organization in yeast and metazoans. Its dysregulation has been link...
Integrated physiological characteristics and proteomes of Bacillus licheniformis response to 6-month spaceflight [0.03%]
芽孢杆菌 lå v冰核菌6个月太空飞行的集成生理特征和蛋白质组学研究
Chunxing Li,Shuyan Shen,Hanwen Zhang et al.
Chunxing Li et al.
Bacillus licheniformis (BL) is used for clinical treatment of acute and chronic enteritis and diarrhea. The present study explored the physiological characteristics and proteomes of BL response to 6-month spaceflight aboard the China Space ...