Risk of adverse pregnancy and birth outcomes after open versus laparoscopic surgery for IBD: a nationwide cohort study [0.03%]
开腹手术与IBD腹腔镜手术后不良妊娠和出生结局的风险：全国队列研究
Anders Mark-Christensen,Anthony Charles Ebert,Gry Juul Poulsen et al.
Anders Mark-Christensen et al.
Background: The aim of this nationwide population-based cohort study was to examine an association between previous open and laparoscopic abdominal surgery for inflammatory bowel disease (IBD) and adverse pregnancy and bi...
Paolo Gionchetti,Nikolas K Dussias,Willem A Bemelman
Paolo Gionchetti
Learning Curve in Intestinal Ultrasound: Advancing from Basic Skills to Advanced Competencies-Insights from the IUS IG-IBD Master Program [0.03%]
肠道超声学习曲线：从基本技能到高级胜任力的提升——来自IUS IG-IBD大师项目的新启示
Cristina Bezzio,Luisa Bertin,Simone Saibeni et al.
Cristina Bezzio et al.
Background: Intestinal ultrasound (IUS) is increasingly valuable in inflammatory bowel disease (IBD) management. Objective: This study ...
Clinical utility of pre-treatment 4-digit resolution HLA genotyping to guide anti-TNF choice and concomitant immunomodulator use [0.03%]
术前四位分辨率HLA基因分型指导抗TNF选择及联合免疫调节剂使用的临床效用
Phoebe Hodges,Christopher Roberts,Miles Parkes et al.
Phoebe Hodges et al.
Background and aims: Immunogenicity and the development of an undetectable drug level is a modifiable cause of anti-TNF treatment failure. We modelled the clinical utility of pre-treatment HLA-DQA1*05:01 and HLA-DQA1*05:0...
Guselkumab-mediated marked improvement in a case of refractory ulcerative colitis resistant to mirikizumab: evidence for switching between IL-23p19 inhibitors [0.03%]
Guselkumab治疗米克珠单抗无效的难治性溃疡性结肠炎患者有效：IL-23p19抑制剂转换治疗的证据
Reiko Kunisaki,Hideaki Kimura,Shin Maeda
Reiko Kunisaki
Risk of serious infections in patients with inflammatory bowel disease treated with biologic and small molecule therapies: A nationwide cohort study [0.03%]
生物制剂和小分子药物治疗炎症性肠病患者严重感染的风险：一项全国队列研究
Jordan Axelrad,Anders Forss,Jonas Söderling et al.
Jordan Axelrad et al.
Background: We aimed to assess the risk of serious infections in patients with inflammatory bowel disease (IBD) exposed to different advanced therapies. M...
HLA-DQA1*05:01 and DQA1*05:05 inform choice of anti-tumor necrosis factor and concomitant use of immunomodulators in patients with inflammatory bowel disease [0.03%]
HLA-DQA1*05:01 和 DQA1*05:05 在炎症性肠病患者选择抗肿瘤坏死因子及联合使用免疫调节剂中的指导作用
Qian Zhang,Mohammed Sharip,Christopher Roberts et al.
Qian Zhang et al.
Background and aims: Loss of response (LoR) is a major limitation of anti-tumor necrosis factor (anti-TNF) therapy in inflammatory bowel disease (IBD). It can result from immunogenicity or other, less well-defined mechani...
Identification of Crohn's disease subtypes in single cell RNA sequencing signatures of treatment naïve samples across the paediatric gastrointestinal tract [0.03%]
基于儿童消化道未接受治疗样本单细胞RNA测序标志物的克罗恩病亚型识别
Savannah Washburn,Yeonjoo Hwang,Sushma Chowdary Maddipatla et al.
Savannah Washburn et al.
Background: Crohn's disease (CD) is characterized by chronic intestinal inflammation. Previous single-cell transcriptomic studies have mostly focused on established disease, leaving a knowledge gap in relation to treatmen...
Efficacy and Safety of Risankizumab in Patients with Moderately to Severely Active Crohn's Disease: Interim Results from the SEQUENCE Open-Label Extension Study [0.03%]
Risankizumab治疗中至重度活动性克罗恩病患者的有效性和安全性：SEQUENCE开放标签延长研究的中期结果
Laurent Peyrin-Biroulet,Raja Atreya,Silvio Danese et al.
Laurent Peyrin-Biroulet et al.
Background and aims: Risankizumab, a selective interleukin-23 p19 inhibitor, is approved to treat moderately to severely active Crohn's disease in adults. We report interim results from part 2 of the ongoing SEQUENCE tria...
The global leadership initiative on malnutrition criteria for the diagnosis of malnutrition in patients with inflammatory bowel disease: a systematic review and meta-analysis [0.03%]
全球领导力倡议：炎症性肠病患者营养不良诊断标准的系统评价和-meta分析
Niki Papageorgiou,Anna-Bettina Haidich,Eirini Pagkalidou et al.
Niki Papageorgiou et al.
Background & aims: This study aims to evaluate the diagnostic accuracy of tools commonly employed in clinical practice for the assessment of malnutrition in patients with inflammatory bowel disease (IBD), including Global...