Post-translational regulation of the mTORC1 pathway: A switch that regulates metabolism-related gene expression [0.03%]
mTORC1通路的翻译后调控：一个调节代谢相关基因表达的开关
Yitao Wang,Tobias Engel,Xinchen Teng
Yitao Wang
The mechanistic target of rapamycin complex 1 (mTORC1) is a kinase complex that plays a crucial role in coordinating cell growth in response to various signals, including amino acids, growth factors, oxygen, and ATP. Activation of mTORC1 pr...
Targeting 'histone mark': Advanced approaches in epigenetic regulation of telomere dynamics in cancer [0.03%]
靶向'组蛋白标记'：癌症端粒动态表观遗传调控的高级方法
Ankita Das,Ashok K Giri,Pritha Bhattacharjee
Ankita Das
Telomere integrity is required for the maintenance of genome stability and prevention of oncogenic transformation of cells. Recent evidence suggests the presence of epigenetic modifications as an important regulator of mammalian telomeres. ...
Prospects and challenges of noncoding-RNA-mediated inhibition of heat shock protein 90 for cancer therapy [0.03%]
非编码RNA介导的热休克蛋白90抑制在癌症治疗中的前景与挑战
Shria Mattoo,Abha Gupta,Manvee Chauhan et al.
Shria Mattoo et al.
Heat Shock Protein 90 (HSP90) is a potential drug target for cancer therapy as it is often dysregulated in several cancers, including lung, breast, pancreatic, and prostate cancers. In cancer, HSP90 fails to maintain the structural and func...
Insight into the mechanism of AML del(9q) progression: hnRNP K targets the myeloid master regulators CEBPA (C/EBPα) and SPI1 (PU.1) [0.03%]
急性髓系白血病del（9q）发病机制的见解：hnRNP K针对髓样核心调节因子CEBPA和SPI1
Kerstin Rahn,Ali T Abdallah,Lin Gan et al.
Kerstin Rahn et al.
Deletions on the long arm of chromosome 9 (del(9q)) are recurrent abnormalities in about 2 % of acute myeloid leukemia cases, which usually involve HNRNPK and are frequently associated with other known aberrations. Based on an Hnrnpk haploi...
Modulation of Krüppel-like factors (KLFs) interaction with their binding partners in cancers through acetylation and phosphorylation [0.03%]
乙酰化和磷酸化调节癌症中的Krüppel样因子(KLFs)相互作用及其结合蛋白
Kanupriya Jha,Amit Kumar,Kartik Bhatnagar et al.
Kanupriya Jha et al.
Post-translational modifications (PTMs) of transcription factors regulate transcriptional activity and play a key role in essentially all biological processes and generate indispensable insight towards biological function including activity...
The association of the RSC remodeler complex with chromatin is influenced by the prefoldin-like Bud27 and determines nucleosome positioning and polyadenylation sites usage in Saccharomyces cerevisiae [0.03%]
SWR1复合体与染色质的结合受Bud27蛋白影响并决定酿酒酵母着丝粒区域组蛋白变体Cse4的定位及多聚腺苷酸化位点的使用分布规律
Abel Cuevas-Bermúdez,Verónica Martínez-Fernández,Ana I Garrido-Godino et al.
Abel Cuevas-Bermúdez et al.
The tripartite interaction between the chromatin remodeler complex RSC, RNA polymerase subunit Rpb5 and prefoldin-like Bud27 is necessary for proper RNA pol II elongation. Indeed lack of Bud27 alters this association and affects transcripti...
Isolation and characterisation of promoters from mouse genome to drive post-meiotic germ cell-specific robust gene expression for functional genomics studies [0.03%]
小鼠基因组中隔离和表征启动子以驱动功能基因组学研究的后减数分裂生殖细胞特异性稳健基因表达
Abhishek Das,Srimoyee Koner,Subeer S Majumdar et al.
Abhishek Das et al.
The generation of spermatozoa from developing germ cells through mitotic and meiotic divisions is a highly regulated and complex process. Any defect in this process, may lead to subfertility/infertility. The role of different transcripts (m...
A poly-histidine motif of HOXA1 is involved in regulatory interactions with cysteine-rich proteins [0.03%]
一个多组氨酸基序通过与富含半胱氨酸的蛋白质相互作用参与HOXA1的调控
Damien Marchese,Florent Guislain,Tamara Pringels et al.
Damien Marchese et al.
Homopolymeric amino acid repeats are found in about 24 % of human proteins and are over-represented in transcriptions factors and kinases. Although relatively rare, homopolymeric histidine repeats (polyH) are more significantly found in pro...
The functions of FOXP transcription factors and their regulation by post-translational modifications [0.03%]
FOXＰ转录因子的功能及其通过翻译后修饰的调节作用
Congwen Gao,Honglin Zhu,Peng Gong et al.
Congwen Gao et al.
The forkhead box subfamily P (FOXP) of transcription factors, consisting of FOXP1, FOXP2, FOXP3, and FOXP4, is involved in the regulation of multisystemic functioning. Disruption of the transcriptional activity of FOXP proteins leads to neu...
DDX5 (p68) orchestrates β-catenin, RelA and SP1 mediated MGMT gene expression in human colon cancer cells: Implication in TMZ chemoresistance [0.03%]
DDX5（p68）通过β-catenin、RelA和SP1介导的MGMT基因表达在人类结肠癌细胞中起协调作用：对TMZ化疗耐药性的意义
Rajni Shaw,Subhajit Karmakar,Malini Basu et al.
Rajni Shaw et al.
DDX5 (p68) upregulation has been linked with various cancers of different origins, especially Colon Adenocarcinomas. Similarly, across cancers, MGMT has been identified as the major contributor of chemoresistance against DNA alkylating agen...