Akihiko Yokoyama,Hiroyuki Niida,Tatiana G Kutateladze et al.
Akihiko Yokoyama et al.
The histone acetyltransferase HBO1, also known as KAT7, is a major chromatin modifying enzyme responsible for H3 and H4 acetylation. It is found within two distinct tetrameric complexes, the JADE subunit-containing complex and BRPF subunit-...
Histone ubiquitination: Role in genome integrity and chromatin organization [0.03%]
组蛋白泛素化及其在基因组稳定性和染色质组织中的功能
Nikhil Baban Ghate,Kaustubh Sanjay Nadkarni,Ganesh Kumar Barik et al.
Nikhil Baban Ghate et al.
Maintenance of genome integrity is a precise but tedious and complex job for the cell. Several post-translational modifications (PTMs) play vital roles in maintaining the genome integrity. Although ubiquitination is one of the most crucial ...
To Ub or not to Ub: The epic dilemma of histones that regulate gene expression and epigenetic cross-talk [0.03%]
泛素或不泛素：调控基因表达和表观遗传交叉对话的组蛋白面临的史诗级抉择
Anirban Dasgupta,Sandhik Nandi,Sayan Gupta et al.
Anirban Dasgupta et al.
A dynamic array of histone post-translational modifications (PTMs) regulate diverse cellular processes in the eukaryotic chromatin. Among them, histone ubiquitination is particularly complex as it alters nucleosome surface area fostering in...
Transcriptional regulation of Znt family members znt4, znt5 and znt10 and their function in zinc transport in yellow catfish (Pelteobagrus fulvidraco) [0.03%]
黄颡鱼锌转运蛋白Znt4、Znt5和Znt10的转录调控及其在锌转运中的功能研究
Lu-Lu Liu,Chang-Chun Song,Nermeen Abu-Elala et al.
Lu-Lu Liu et al.
The study characterized the transcriptionally regulatory mechanism and functions of three zinc (Zn) transporters (znt4, znt5 and znt10) in Zn2+ metabolism in yellow catfish (Pelteobagrus fulvidraco), commonly freshwater fish in China and ot...
Key interactions of RNA polymerase with 6S RNA and secondary channel factors during pRNA synthesis [0.03%]
RNA聚合酶与6S RNA和次级通道因子在pRNA合成期间的关键相互作用
Ivan Petushkov,Daria Elkina,Olga Burenina et al.
Ivan Petushkov et al.
Small non-coding 6S RNA mimics DNA promoters and binds to the σ70 holoenzyme of bacterial RNA polymerase (RNAP) to suppress transcription of various genes mainly during the stationary phase of cell growth or starvation. This inhibition can...
A promoter-dependent upstream activator augments CFTR expression in diverse epithelial cell types [0.03%]
一种启动子依赖的上游激活因子增强多种上皮细胞类型的CFTR表达
Giuliana C Coatti,Nirbhayaditya Vaghela,Pulak Gillurkar et al.
Giuliana C Coatti et al.
The cystic fibrosis transmembrane conductance regulator (CFTR) gene encodes an anion-selective channel found in epithelial cell membranes. Mutations in CFTR cause cystic fibrosis (CF), an inherited disorder that impairs epithelial function ...
TAT38 and TAT38 mimics potently inhibit adipogenesis by repressing C/EBPα, PPARγ, Pi-PPARγ, and SREBP1 expression [0.03%]
TAT38和TAT38模拟物通过抑制C/EBPα，PPARγ，Pi-PPARγ和SREBP1的表达强烈地抑制脂肪细胞生成
Sun-Young Park,Dongyoon Shin,Young So Yoon et al.
Sun-Young Park et al.
Antiretroviral therapy-naive people living with HIV possess less fat than people without HIV. Previously, we found that HIV-1 transactivator of transcription (TAT) decreases fat in ob/ob mice. The TAT38 (a.a. 20-57) is important in the inhi...
Structural basis of the interaction between TFIIS and Leo1 from Arabidopsis thaliana [0.03%]
拟南芥TFIIS和Leo1的相互作用的结构基础
Yuzhu Wang,Meng Chen,Haoyu Ma et al.
Yuzhu Wang et al.
Katiuska González-Arzola
Katiuska González-Arzola
The perception that the nucleoli are merely the organelles where ribosome biogenesis occurs is challenged. Only around 30 % of nucleolar proteins are solely involved in producing ribosomes. Instead, the nucleolus plays a critical role in co...
The role of nucleotide opening dynamics in facilitated target search by DNA-repair proteins [0.03%]
核苷酸开启动力学在DNA修复蛋白介导的靶位寻觅中的作用
Sujeet Kumar Mishra,Sangeeta,Dieter W Heermann et al.
Sujeet Kumar Mishra et al.
Preserving the genomic integrity stands a fundamental necessity, primarily achieved by the DNA repair proteins through their continuous patrolling on the DNA in search of lesions. However, comprehending how even a single base-pair lesion ca...