DUSP1 protein's impact on breast cancer: Anticancer response and sensitivity to cisplatin [0.03%]
DUSP1蛋白对乳腺癌的影响：抗癌反应和顺铂敏感性
Sefa Metin,Hilal Altan,Ergün Tercan et al.
Sefa Metin et al.
Dual-Specificity Phosphatase 1 (DUSP1) modulates the activity of members of the Mitogen-Activated Protein Kinase (MAPK) family, including p38, JNK, and ERK1/2, which affects various cellular functions in cancer. Moreover, DUSP1 is known to ...
RhoA functionally collaborates with HSPA1A to promote the migratory phenotype of cancer cells [0.03%]
RhoA与HSPA1A功能协作以促进癌细胞迁移表型
Sumaiya Nabi,Mohammad Amin Hajam,Umar Mushtaq et al.
Sumaiya Nabi et al.
RhoA, a member of the GTPase family, plays a pivotal role in attaining a migratory phenotype, mainly by regulating cytoskeleton dynamics, cell adhesion and membrane protrusions. Although many upstream regulators and downstream effectors of ...
ARID1A-driven modulation of EZH2 impedes proliferation and enhances senescence in breast cancer cells [0.03%]
ARID1A通过调节EZH2抑制乳腺癌细胞增殖并促进衰老效应
Neena George,Rayzel Fernandes,Kapaettu Satyamoorthy
Neena George
ARID1A mutations, in association with EZH2 overexpression, are linked to various malignancies, particularly those driven by epigenetic dysregulation and associated with therapy resistance. The prevalence of ARID1A mutations is high in ER+ b...
Growth rate is related to elongation of RNA polymerase II transcription in Saccharomyces cerevisiae [0.03%]
酿酒酵母中生长速率与RNA聚合酶II转录延伸相关
A I Garrido-Godino,R González,M Martín-Expósito et al.
A I Garrido-Godino et al.
Cells must adapt to changing environmental conditions to maintain their fitness and to compete with other genotypes during the natural selection process. The growth rate (GR) is a determining factor in this competition, and it influences ge...
Navigating the tumor landscape: VEGF, MicroRNAs, and the future of cancer treatment [0.03%]
肿瘤导航：VEGF、MicroRNA与癌症治疗的未来
K P Ameya,P P Ashikha Shirin Usman,Durairaj Sekar
K P Ameya
Cancer progression is a multifaceted process influenced by complex interactions within the tumor microenvironment (TME). Central to these dynamics are Vascular Endothelial Growth Factor (VEGF) signalling and microRNA (miRNA) modulation, bot...
The crucial role of small heat shock proteins in prostate cancer: mechanisms and new therapeutic perspectives [0.03%]
小热休克蛋白在前列腺癌中的关键作用：机制和新的治疗视角
Yuankang Feng,Jialu Ma,Zhihao Bo et al.
Yuankang Feng et al.
As resistance to new anti-androgen drugs occurs more frequently, increasing numbers of researchers are exploring alternative key molecular targets for prostate cancer treatment. The small heat shock protein (sHSP) family is a subclass of he...
Genome-wide screening reveals repression by nuclear exosome as a prerequisite for intron-mediated enhancement in Saccharomyces cerevisiae [0.03%]
全基因组筛选揭示了核外切体介导的转录后沉默是酿酒酵母中内含子增强的基本条件
Hiroki Kikuta,Shunya Takeda,Rinji Akada et al.
Hiroki Kikuta et al.
Introns can enhance gene expression, a phenomenon called intron-mediated enhancement (IME). Previously proposed IME mechanisms do not sufficiently explain the variability in enhancement levels, suggesting that IME mechanism has not been ful...
Specific DNA features of the RNA polymerase I core promoter element targeted by core factor [0.03%]
RNA聚合酶I核心启动子元件的特异性DNA特征与其结合的核心因子有关
Nathan J Munoff,Brian J Zeberl,Matthew A Palmer et al.
Nathan J Munoff et al.
RNA polymerase I (Pol I) is essential for ribosomal RNA (rRNA) synthesis, driving ribosome biogenesis in eukaryotes. Transcription initiation by Pol I requires core factor (CF) binding to the core element (CE) of the ribosomal DNA (rDNA) pr...
Hypoxia inducible factor HIF1α elevates expression of mRNA capping enzyme during cobalt chloride-induced hypoxia [0.03%]
一氧化碳氯化物诱导的低氧条件下，缺氧诱导因子HIF1α上调mRNA加帽酶表达
Safirul Islam,Chandrama Mukherjee
Safirul Islam
In response to hypoxia, hypoxia-inducible factors (HIFs) control the transcriptomic output to mitigate the hypoxic stress. Long noncoding RNAs (lncRNA) are found to be very crucial in regulating hypoxia. Like mRNAs, lncRNAs are protected by...
Transcription factors associated with regulation of transcriptome in human thigh and calf muscles at baseline and after six days of disuse [0.03%]
人体大腿和小腿肌肉在失用六天前后与转录组调节相关的转录因子
Anna A Borzykh,Pavel A Makhnovskii,Ivan I Ponomarev et al.
Anna A Borzykh et al.
Disuse has a negative impact on the postural muscles of the trunk and legs. Different leg muscles demonstrate a differentiated and conservative response to disuse, in terms of a decrease in muscle mass, strength, aerobic performance, and ch...