Brigitta Veda Devani,Hye Su Moon,Ana Braza et al.
Brigitta Veda Devani et al.
Ten-eleven translocation 2 (Tet2) catalyzes the conversion of 5-methylcytosine to 5-hydroxymethylcytosine, facilitating active DNA demethylation. Although implicated in adipogenesis, its precise role remains controversial. Here, we investig...
miR-149-3p-mediated TIMP3 restoration suppresses tumor aggressiveness in sorafenib-resistant liver cancer cell [0.03%]
microRNA-149-3p介导的TIMP3恢复可抑制索拉非尼耐药肝癌细胞的恶性肿瘤侵袭性
Sanghee Park,Taehyun Park,Dayoung Choi et al.
Sanghee Park et al.
Hepatocellular carcinoma (HCC) is a highly lethal malignancy in which acquired resistance to sorafenib remains a major therapeutic challenge. To investigate mechanisms of resistance, we performed transcriptomic profiling of sorafenib-resist...
UpRoi1 - the phage-derived microRNA-size non-coding RNA molecule regulating both phage and its bacterial host development [0.03%]
UpRoi1——一种源自噬菌体的微小核糖核酸大小的非编码核糖核酸分子，可调节噬菌体及其细菌宿主的发展
Sylwia Bloch,Natalia Lewandowska,Joanna Zwolenkiewicz-Nowak et al.
Sylwia Bloch et al.
The phage Φ24B-encoded small RNA (sRNA), named UpRoi1, was identified following the prophage induction. The UpRoi1 molecule is encoded in the antirepressor region of the phage genome and is notably small, consisting of only 30 nucleotides....
SP1 as a negative regulator of ADAMTS-8 in colorectal cancer: Evidence from functional and molecular analyses [0.03%]
SP1通过功能和分子分析作为结直肠癌中ADAMTS-8的负调节因子的作用证据
Yasemin Kalfa,Feyza Nur Sav,Meltem Alper et al.
Yasemin Kalfa et al.
Epigenetic silencing of ADAMTS-8 has been linked to increased tumor aggressiveness and poor prognosis; however, its transcriptional regulation in cancer remains largely undefined. Here, we comprehensively investigated the transcriptional re...
Autophagy-related genes and encoded proteins' prognostic significance in various cancer types: A molecular perspective [0.03%]
自噬相关基因及其编码蛋白在各种癌症类型中的预后意义：分子视角下的研究
Eman A Amr,Ola A El-Feky,Nahla E El-Ashmawy et al.
Eman A Amr et al.
Autophagy is a degradative process for recycling and breaking down cellular components, with several context-dependent functions in the development of tumors and resistance to therapy. Numerous clinical trials aiming to target autophagy in ...
Roles of novel post-translational modifications in the male reproductive system: From regulation of reproductive development to therapeutic potential [0.03%]
新型翻译后修饰在雄性生殖系统中的作用：从调节生殖发育到治疗潜力
Xin-Rong Du,Yan Gao,Qin Zeng et al.
Xin-Rong Du et al.
Post-translational modifications (PTMs) play a pivotal role in understanding male reproductive function, with an increasing number of PTMs being demonstrated to be associated with spermatogenesis and sperm function. The advancement of high-...
Estrogen produced in the retina by brain aromatase plays a significant role in zebrafish eye development [0.03%]
由大脑芳香化酶在视网膜中产生的雌激素在斑马鱼眼发育中起重要作用
Zulvikar Syambani Ulhaq,Mitsuyo Kishida
Zulvikar Syambani Ulhaq
Aromatase is a key enzyme in estrogen biosynthesis, expressed in multiple tissues including the brain and retina. In teleost fish, Aromatase B (AroB), encoded by cyp19a1b, is brain-specific and highly expressed during early development, sug...
Expression of two forms of the calcium/calmodulin-dependent protein kinase Cmk2 is differentially regulated in response to calcium stress in budding yeast [0.03%]
芽裂酵母中钙离子/CaM依赖的蛋白激酶Cmk2两种形式对钙离子胁迫反应的表达调控不同
Linghuo Jiang,Liudan Wei,Yiying Gu et al.
Linghuo Jiang et al.
Cmk2 is a homolog of mammalian calcium/calmodulin-dependent protein kinase II (CaMKII), and functions as a negative regulator of calcium signaling in yeast cells. Transcription of CMK2 gene is controlled by the zinc finger transcription fac...
Effects of disease severity on RNA integrity measures in necrotising soft tissue infection as a possible source of research bias: An observational cohort study [0.03%]
疾病严重程度对坏死性软组织感染中RNA完整性的测量的影响及其可能带来的研究偏差：一项观察性队列研究
Julie Vinkel,Edoardo Saccenti,Bart Nijsse et al.
Julie Vinkel et al.
RNA sequencing is increasingly being employed in clinical studies. During data pre-processing, samples are typically excluded from further analysis based on quality metrics that assess the integrity of the intermediate genomic product. RNA ...
Identification of a novel p65-p68 loop: A crucial determinant for p68 gene regulation in oncogenesis [0.03%]
鉴定出一个新的p65-p68环路：在肿瘤发生过程中调控p68基因的一个重要因素
Mrinal K Ghosh,Sunny Kumar,Veenita Khare et al.
Mrinal K Ghosh et al.
DEAD-box RNA helicase DDX5 (p68), located on chromosome 17, specifically at the 17q23.3 region), is overexpressed in most of the cancers, including colorectal cancer (CRC) and glioma, thereby gaining prominence as a potential biomarker. The...