Iron restriction increases the expression of a cytotoxic cysteine proteinase TvCP2 by a novel mechanism of tvcp2 mRNA alternative polyadenylation in Trichomonas vaginalis [0.03%]
铁限制通过调节Trichomonas vaginalis中tvcp2 mRNA的可选多聚腺苷酸化增加细胞毒性的半胱氨酸蛋白酶TvCP2的新机制下的表达
Luis Alberto Rivera-Rivas,Rossana Arroyo
Luis Alberto Rivera-Rivas
Trichomonas vaginalis TvCP2 (TVAG_057000) is a cytotoxic cysteine proteinase (CP) expressed under iron-limited conditions. This work aimed to identify one of the mechanisms of tvcp2 gene expression regulation by iron at the posttranscriptio...
Post-translational regulation of proto-oncogene ZBTB7A expression by p53 status in cancer cells: HSP90-dependent stabilization vs. p53-KLHL20-ubiquitin proteasomal degradation [0.03%]
癌细胞中热休克蛋白90依赖型稳定与p53-KLHL20-泛素-蛋白酶体降解调节原癌基因ZBTB7A表达的翻译后调控：取决于p53状态
Seo-Hyun Choi,Su-Yeon Cho,Sun Young Park et al.
Seo-Hyun Choi et al.
ZBTB7A overexpressed in many human cancers is a major oncogenic driver. ZBTB7A promotes tumorigenesis by regulating transcription of the genes involved in cell survival and proliferation, apoptosis, invasion, and migration/metastasis. One u...
Formation of aggresomes with hydrogel-like characteristics by proteasome inhibition [0.03%]
蛋白酶体抑制诱导的类水凝胶性质的aggresome形成
Seo Hyeong Park,Sang-Eun Lee,Jun Hyoung Jeon et al.
Seo Hyeong Park et al.
The spatiotemporal sequestration of misfolded proteins is a mechanism by which cells counterbalance proteome homeostasis upon exposure to various stress stimuli. Chronic inhibition of proteasomes results in a large, juxtanuclear, membrane-l...
The DEAD-box RNA helicase DDX5 (p68) and β-catenin: The crucial regulators of FOXM1 gene expression in arbitrating colorectal cancer [0.03%]
DEAD盒RNA解旋酶DDX5（p68）和β-catenin：在结直肠癌中仲裁FOXM1基因表达的关键调节因子
Shaheda Tabassum,Malini Basu,Mrinal K Ghosh
Shaheda Tabassum
Forkhead box M1 (FOXM1), a vital member of the Forkhead box family of transcription factors, helps in mediating oncogenesis. However, limited knowledge exists regarding the mechanistic insights into the FOXM1 gene regulation. DDX5 (p68), an...
Ah Jung Heo,Su Bin Kim,Yong Tae Kwon et al.
Ah Jung Heo et al.
The N-degron pathway is a degradative system in which single N-terminal (Nt) amino acids regulate the half-lives of proteins and other biological materials. These determinants, called N-degrons, are recognized by N-recognins that link them ...
The SAGA HAT module is tethered by its SWIRM domain and modulates activity of the SAGA DUB module [0.03%]
SAGA的HAT模块通过其SWIRM结构域与DUB模块互作并调节其活性
Sara T Haile,Sanim Rahman,James K Fields et al.
Sara T Haile et al.
The SAGA (Spt-Ada-Gcn5 acetyltransferase) complex is a transcriptional co-activator that both acetylates and deubiquitinates histones. The histone acetyltransferase (HAT) subunit, Gcn5, is part of a subcomplex of SAGA called the HAT module....
Damaged collagen detected by collagen hybridizing peptide as efficient diagnosis marker for early hepatic fibrosis [0.03%]
胶原杂交肽检测受损胶原作为早期肝纤维化高效诊断标志物
Ping Tao,Jinfang Liu,Yuan Li et al.
Ping Tao et al.
Liver fibrosis is characterized by excessive synthesis and deposition of extracellular matrix (ECM) in liver tissues. However, it still has been lacking of early detection and diagnosis methods. The collagen hybridizing peptide (CHP) is a n...
METTL3 activates PERK-eIF2α dependent coelomocyte apoptosis by targeting the endoplasmic reticulum degradation-related protein SEL1L in echinoderms [0.03%]
刺螠纲螠虫动物中METTL3通过靶向内质网相关降解蛋白SEL1L激活PERK-eIF2α依赖性的腔细胞凋亡
Dongdong Li,Ming Guo,Zhimeng Lv et al.
Dongdong Li et al.
N6-methyladenosine (m6A) plays an important role in regulating many physiological and disease processes in vertebrates, in which methyltransferase-like 3 (METTL3) is the best-known m6A methyltransferase. However, the functional roles of inv...
RelB represses miR-193a-5p expression to promote the phenotypic transformation of vascular smooth muscle cells in aortic aneurysm [0.03%]
RelB通过抑制miR-193a-5p表达促进主动脉瘤中血管平滑肌细胞表型转化
Yisi Liu,Xiaoxiang Tian,Dan Liu et al.
Yisi Liu et al.
Aortic aneurysm (AA) is a potentially fatal disease with the possibility of rupture, causing high mortality rates with no effective drugs for the treatment of AA. The mechanism of AA, as well as its therapeutic potential to inhibit aneurysm...
Martin Grønbæk-Thygesen,Caroline Kampmeyer,Kay Hofmann et al.
Martin Grønbæk-Thygesen et al.
A moonlighting protein is one, which carries out multiple, often wholly unrelated, functions. The RAD23 protein is a fascinating example of this, where the same polypeptide and the embedded domains function independently in both nucleotide ...