Crystal structure of Tudor domain of TDRD3 in complex with a small molecule antagonist [0.03%]
TDRD3的Tudor结构域与小分子拮抗剂复合物的晶体结构
Meixia Chen,Zhuowen Wang,Weiguo Li et al.
Meixia Chen et al.
Tudor domain-containing protein 3 (TDRD3) is involved in regulating transcription and translation, promoting breast cancer progression, and modulating neurodevelopment and mental health, making it a promising therapeutic target for associat...
Minh Chau Nguyen,Duo Wang,Brianna J Klein et al.
Minh Chau Nguyen et al.
Taf14 is a subunit of multiple fundamental complexes implicated in transcriptional regulation and DNA damage repair in yeast cells. Here, we investigate the association of Taf14 with the consensus sequence present in other subunits of these...
PP2A and its adapter protein IER5 induce the DNA-binding ability and target gene expression of E2F1 via dephosphorylation at serine 375 [0.03%]
蛋白磷酸酶PP2A及其辅助蛋白IER5通过去磷酸化作用诱导E2F1的DNA结合活性及靶基因表达
Hiroto Takeuchi,Mayuko Koga,Kuriko Doi et al.
Hiroto Takeuchi et al.
The transcription factor E2F1 participates in cell cycle control through transcriptional activation of genes that promote S-phase entry. E2F1 is also linked to the expression of proapoptotic genes, and the loss of E2F1 activity facilitates ...
The yeast mRNA-binding protein Cth2 post-transcriptionally modulates ergosterol biosynthesis in response to iron deficiency [0.03%]
酵母mRNA结合蛋白Cth2通过铁缺乏调控麦角固醇生物合成
Tania Jordá,Nicolas Rozès,María Teresa Martínez-Pastor et al.
Tania Jordá et al.
Sterol synthesis is an iron-dependent metabolic pathway in eukaryotes. Consequently, fungal ergosterol biosynthesis (ERG) is down-regulated in response to iron deficiency. In this report, we show that, upon iron limitation or overexpression...
The fine-tuned crosstalk between lysine acetylation and the circadian rhythm [0.03%]
精炼调节的赖氨酸乙酰化与生物钟之间的相互作用
Honglv Jiang,Xiaohui Wang,Jingjing Ma et al.
Honglv Jiang et al.
Circadian rhythm is a roughly 24-h wake and sleep cycle that almost all of the organisms on the earth follow when they execute their biological functions and physiological activities. The circadian clock is mainly regulated by the transcrip...
A novel endoplasmic reticulum adaptation is critical for the long-lived Caenorhabditis elegans rpn-10 proteasomal mutant [0.03%]
一种新型的内质网适应模式对于长寿命的线虫蛋白酶体突变体rpn-10至关重要
Meghna N Chinchankar,William B Taylor,Su-Hyuk Ko et al.
Meghna N Chinchankar et al.
The loss of proteostasis due to reduced efficiency of protein degradation pathways plays a key role in multiple age-related diseases and is a hallmark of the aging process. Paradoxically, we have previously reported that the Caenorhabditis ...
New roles for elongation factors in RNA polymerase II ubiquitylation and degradation [0.03%]
RNA聚合酶II泛素化和降解中的延长因子新角色
Joseph C Reese
Joseph C Reese
RNA polymerase II (RNAPII) encounters numerous impediments on its way to completing mRNA synthesis across a gene. Paused and arrested RNAPII are reactivated or rescued by elongation factors that travel with polymerase as it transcribes DNA....
Ubiquitination is a major modulator for the activation of inflammasomes and pyroptosis [0.03%]
泛素化是炎性体活化和焦亡形成的主要调控机制
Qiuyun Jiang,Zhigang Zhu,Xinliang Mao
Qiuyun Jiang
Inflammasomes are a central node of the innate immune defense system against the threat of homeostatic perturbance caused by pathogenic organisms or host-derived molecules. Inflammasomes are generally composed of multimeric protein complexe...
Quantitative proteomics revealed the transition of ergosterol biosynthesis and drug transporters processes during the development of fungal fluconazole resistance [0.03%]
基于子囊菌对氟康唑耐药性发展过程中固醇生物合成及药物转运蛋白的定量蛋白质组学研究
Xinying Sui,Xinyu Cheng,Zhaodi Li et al.
Xinying Sui et al.
Fungal infections and antifungal resistance are the increasing global public health concerns. Mechanisms of fungal resistance include alterations in drug-target interactions, detoxification by high expression of drug efflux transporters, an...
TRIM25-mediated ubiquitination of G3BP1 regulates the proliferation and migration of human neuroblastoma cells [0.03%]
TRIM25介导的G3BP1泛素化调控人类神经母细胞瘤细胞增殖和迁移
Yun Yang,Yanyan Luo,Cong Yang et al.
Yun Yang et al.
Neuroblastoma is one of the most severe malignant tumors and accounts for substantial cancer-related mortality in children. Ras-GTPase-activating protein SH3 domain-binding protein 1 (G3BP1) is highly expressed in various cancers and acts a...