Post-translational modifications in stress granule and their implications in neurodegenerative diseases [0.03%]
应激颗粒中的翻译后修饰及其在神经退行性疾病中的影响
Zhangshun Wang,Chen&#x;ang Zhang,Chengyu Fan et al.
Zhangshun Wang et al.
Stress granules (SGs) arise as formations of mRNAs and proteins in response to translation initiation inhibition during stress. These dynamic compartments adopt a fluidic nature through liquid-liquid phase separation (LLPS), exhibiting a co...
Unraveling the battle for lysine: A review of the competition among post-translational modifications [0.03%]
解开赖氨酸之战：转译后修饰之间竞争的综述
Ali H Shukri,Valentina Lukinović,François Charih et al.
Ali H Shukri et al.
Proteins play a critical role as key regulators in various biological systems, influencing crucial processes such as gene expression, cell cycle progression, and cellular proliferation. However, the functions of proteins can be further modi...
Inflammation-induced nitric oxide suppresses PPARα expression and function via downregulation of Sp1 transcriptional activity in adipocytes [0.03%]
炎症诱导的内源性硝酸盐通过下调Sp1转录活性抑制脂肪细胞中PPARα的表达和功能
Jungin Kwon,Yumeko Aoki,Haruya Takahashi et al.
Jungin Kwon et al.
The activation of peroxisome proliferator-activated receptor alpha (PPARα), a ligand-dependent transcription factor that regulates lipid oxidation-related genes, has been employed to treat hyperlipidemia. Emerging evidence indicates that P...
Entanglement of MAPK pathways with gene expression and its omnipresence in the etiology for cancer and neurodegenerative disorders [0.03%]
MAPK通路与基因表达的纠缠及其在癌症和神经退行性疾病病因学中的普遍存在性
Joydeep Chakraborty,Sayan Chakraborty,Sohag Chakraborty et al.
Joydeep Chakraborty et al.
Mitogen Activated Protein Kinase (MAPK) is one of the most well characterized cellular signaling pathways that controls fundamental cellular processes including proliferation, differentiation, and apoptosis. These cellular functions are con...
KDM5A noncanonically binds antagonists MLL1/2 to mediate gene regulation and promotes epithelial to mesenchymal transition [0.03%]
KDM5A通过非典型地结合MLL1/2拮抗物介导基因调控并促进上皮间质转化
R Kirtana,Soumen Manna,Samir Kumar Patra
R Kirtana
Differential expression of genes involved in certain processes is a collaborative outcome of crosstalk between signalling molecules and epigenetic modifiers. In response to environmental stimulus, interplay between transcription factors and...
The mechanism of UP1 binding and unfolding of human telomeric DNA G-quadruplex [0.03%]
UP1结合和展开人类端粒DNA G-四链体的机制研究
Xiaobin Ling,Yuqi Yao,Lei Ding et al.
Xiaobin Ling et al.
The human telomere contains multiple copies of the DNA sequence d(TTAGGG) which can fold into higher order intramolecular G-quadruplexes and regulate the maintenance of telomere length and chromosomal integrity. The nucleic acid binding pro...
Regulation of SARS-CoV-2 infection and antiviral innate immunity by ubiquitination and ubiquitin-like conjugation [0.03%]
泛素化和泛素样结合修饰调节SARS-CoV-2感染和抗病毒先天免疫反应
Yi Zheng,Huiyu Yang,Xuejing Zhang et al.
Yi Zheng et al.
A global pandemic COVID-19 resulting from SARS-CoV-2 has affected a significant portion of the human population. Antiviral innate immunity is critical for controlling and eliminating the viral infection. Ubiquitination is extensively involv...
Post translational modifications at the verge of plant-geminivirus interaction [0.03%]
植物与双生病毒互作中的翻译后修饰研究
Ashish Prasad,Shambhavi Sharma,Manoj Prasad
Ashish Prasad
Plant-virus interaction is a complex phenomenon and involves the communication between plant and viral factors. Viruses have very limited coding ability yet, they are able to cause infection which results in huge agro-economic losses throug...
The presence of an intron relieves gene repression caused by promoter-proximal four-bp specific sequences in yeast [0.03%]
内含子的存在可以缓解酵母中启动子附近4 bp特异性序列引起的基因抑制作用
Hiroki Kikuta,Takahiro Aramaki,Shingo Mabu et al.
Hiroki Kikuta et al.
Introns can enhance gene expression in eukaryotic cells in a process called intron-mediated enhancement (IME). The levels of enhancement are affected not only by the intron sequence but also by coding sequences (CDSs). However, the parts of...
Priyanka Barman,Pritam Chakraborty,Rhea Bhaumik et al.
Priyanka Barman et al.
SAGA (Spt-Ada-Gcn5-Acetyltransferase), an evolutionarily conserved transcriptional co-activator among eukaryotes, is a large multi-subunit protein complex with two distinct enzymatic activities, namely HAT (Histone acetyltransferase) and DU...