Targeting kinases in neurodegenerative diseases and cancer: Structural insights and therapeutic strategies [0.03%]
针对神经退行性疾病和癌症中的激酶：结构见解与治疗策略
Anas Shamsi,Saleha Anwar,Khuzin Dinislam
Anas Shamsi
Protein kinases play a key role in cellular signalling and are key drivers of neoplasia. In comparison, their role in neurodegenerative diseases used to be considered as secondary or downstream effects of neuronal damage. A growing body of ...
Cross-cancer transcriptomic integration identifies a core immune-signaling network in hormone-driven malignancies [0.03%]
跨癌种转录组整合鉴定激素驱动型恶性肿瘤中的核心免疫信号网络
Prasanna Kumar Selvam,Supraja Mohan,Karthick Vasudevan
Prasanna Kumar Selvam
Hormone-dependent malignancies, including breast, ovarian, thyroid, and prostate cancers, are driven by dysregulated endocrine signaling but exhibit marked heterogeneity in molecular architecture and therapeutic response. Whether these canc...
Shared molecular dysregulation across neuropsychiatric disorders reveals candidate therapeutic targets [0.03%]
跨神经精神疾病共有的分子失调揭示了潜在的治疗靶点
Supraja Mohan,Prasanna Kumar Selvam,Karthick Vasudevan
Supraja Mohan
Autism Spectrum Disorder (ASD), Bipolar Disorder (BD), and Schizophrenia (SCZ) are major neuropsychiatric conditions that contribute substantially to global disability. Although traditionally considered distinct disorders, increasing eviden...
Screening of prospective biofilm-inhibitory drug candidates aimed at the biofilm-associated protein (BAP) in Staphylococcus aureus: An in-silico investigation [0.03%]
针对金黄色葡萄球菌生物被膜相关蛋白(BAP)的潜在抑制药物筛选：一项基于计算机的研究
Sree Haryini,Mohanraj Gopikrishnan,Magesh Ramasamy et al.
Sree Haryini et al.
Staphylococcus aureus is the leading pathogen responsible for hospital- and community-acquired infections. The increasing prevalence of nosocomial infections in healthcare settings presents a significant challenge, particularly due to the s...
Computational exploration of high-throughput virtual screening and molecular dynamics analysis targeting BfmR in Acinetobacter baumannii: Towards anti-virulent therapeutics [0.03%]
计算高通量虚拟筛选和分子动力学分析针对鲍曼不动杆菌BfmR的靶点：迈向抗菌活性药物
Mohanraj Gopikrishnan,D Thirumal Kumar,George Priya Doss C
Mohanraj Gopikrishnan
The opportunistic pathogen Acinetobacter baumannii, a major cause of nosocomial infections, has exhibited a rapid increase in resistance to conventional antimicrobial therapies, emphasizing the urgent need for alternative strategies such as...
Precision therapeutics for wound healing: Molecular targets, signalling networks, and advanced drug design strategies [0.03%]
精准伤口愈合疗法：分子靶点、信号通路和先进的药物设计策略
Sibiya Ashokkumar,Rishi Ganesh Sonniyan Kumar,Esakkimuthu Shanmugasundaram
Sibiya Ashokkumar
The therapeutic manipulation concerning towards wound healing meets the different macroscopic levels such as immunological mechanisms, molecular signalling networks, developmental biology (regeneration) and drug discovery. From the epiderma...
Marine-Derived bioactives as precision modulators of molecular targets: Emerging paradigms in therapeutic design [0.03%]
海洋衍生生物活性物质作为精确调节分子靶点的调控剂——药物设计中的新范例
Solaiyappan Ramanathan,Kothaimanimaran Brindha,Periyasamy Vijayalakshmi et al.
Solaiyappan Ramanathan et al.
Oceanic environments represent a unique source of biologically active substances, which has a large spectrum of chemical composition, and has significant therapeutic potential. Marine-derived bioactive compounds have emerged as accuracy reg...
Energetic landscapes and fuzzy complexes: Computational targeting of viral intrinsically disordered proteins [0.03%]
能量景观和模糊复合物：计算靶向病毒内在无序蛋白
Kumar Viknesh,Periyasamy Vijayalakshmi,Asha Monica Alex et al.
Kumar Viknesh et al.
The increased recognition of intrinsically disordered proteins (IDPs) as critical mediators in viral infections has shifted attention toward fuzzy drug targets, challenging the conventional structure-based paradigms of drug discovery due to...
Molecular characterization and experimental models of chordoma: Foundations for rational therapy development [0.03%]
软骨肉瘤的分子特征和实验模型：理性药物开发的基础
Christian Godinez,Matthew Holman,Emilija Sagaityte et al.
Christian Godinez et al.
Advancing therapeutic strategies for chordoma requires a deep molecular understanding of tumor biology, supported by robust and reproducible experimental models. This chapter reviews recent progress in the development of in vitro and in viv...
Clinical challenges and therapeutic strategies in chordoma: Translating molecular insights into patient care [0.03%]
黏液瘤的临床挑战和治疗策略：将分子机理转译为病人护理的新策略
Beatrice Campilan,Weston C de Lomba,Madison J Michles et al.
Beatrice Campilan et al.
Chordoma is a rare, locally aggressive bone tumor originating from notochordal remnants. Despite advances in surgical and radiation-based approaches, effective systemic therapies remain limited, and recurrence rates are high. This chapter e...