Antimicrobial peptides: Bridging mechanistic understanding and novel applications [0.03%]
抗菌肽研究：从机制洞察到新型应用
Wanzhen Dai,Bee K Tan,Jiamiao Hu
Wanzhen Dai
Antimicrobial peptides (AMPs), which can be derived from diverse biological sources, exhibit a broad spectrum of inhibitory activity against bacteria, fungi, parasites, and viruses, positioning them as promising alternatives to traditional ...
Computational structure-based evaluation of antimicrobial peptides against OXA-51 β-lactamase in carbapenem-resistant Acinetobacter baumannii [0.03%]
基于计算的结构评价抗菌肽对碳青霉烯耐药鲍曼不动杆菌中OXA-51β-内酰胺酶的作用
Mohanraj Gopikrishnan,George Priya Doss C
Mohanraj Gopikrishnan
Antimicrobial peptides (AMPs) constitute a promising class of next-generation therapeutics, exhibiting broad-spectrum efficacy and a diminished propensity for inducing resistance. Recent strides in computational biology have facilitated the...
The multifaceted role of antimicrobial peptides in neurodegeneration: Insights from Drosophila and beyond [0.03%]
抗菌肽在神经退行性疾病中的多面作用：来自果蝇及其他系统的启示
Priyatama Behera,Nagaraj Rangappa,Madhura Chandrashekar et al.
Priyatama Behera et al.
Antimicrobial peptides (AMPs) are tiny proteins essential for innate immunity in various taxa, including mammals and insects. They provide defence against a wide range of pathogens, including bacteria, viruses, fungi, and parasites. Apart f...
Antimicrobial peptides act as a component of brain immunity against microbes in Alzheimer's disease [0.03%]
抗菌肽在阿尔茨海默病中作为大脑免疫系统对抗微生物的成分发挥作用
Madhura Chandrashekar,Gowshika Velmurugan,Amit Mishra et al.
Madhura Chandrashekar et al.
Alzheimer's disease is a most prevalent type of dementia in elderly people. Extracellular accumulation of Amyloid-β (Aβ) and intracellular aggregation of Tau NFTs in the brain is proposed to be a key factor in the development of Alzheimer...
Antimicrobial peptides inhibit Tau aggregation and modulates its pathology [0.03%]
抗菌肽抑制Tau蛋白聚集并调节其病理状况
Subashchandrabose Chinnathambi,Nagaraj Rangappa,Sneha Malik
Subashchandrabose Chinnathambi
Alzheimer's disease is mainly caused by two proteins, Tau and Amyloid-β. While there are several cures currently being explored for it, there is no cure yet for the disease progression and prevention, but only those to alleviate the sympto...
Deciphering antimicrobial peptide (AMP) resistance mechanisms in Enterococcus faecalis through integrated RNA-Seq and hub genes identification [0.03%]
通过整合RNA-Seq和核心基因鉴定解析粪肠球菌的抗菌肽(AMP)耐药机制
J Deepika,Aishwarya C Shetty,DhanushKumar T et al.
J Deepika et al.
Antimicrobial resistance (AMR) remains a critical global health threat, necessitating innovative approaches to combat drug-resistant bacteria. This study investigates the genetic basis of resistance in Enterococcus faecalis, a Gram-positive...
Unraveling the role of antimicrobial proteins in leptospirosis: A comprehensive transcriptomic analysis [0.03%]
链球菌抗微生物蛋白的作用机制：全面的转录组分析
Nivedya Kottarath,Megha Hari,Prasanna Kumar Selvam et al.
Nivedya Kottarath et al.
Leptospirosis, caused by Leptospira bacteria, poses a significant global health threat with notable mortality rates. This study employs advanced transcriptomics to explore the complex interactions between host and pathogen, focusing on anti...
Structural insights, immunomodulatory functions, and therapeutic potential of host defense peptides in avoiding antimicrobial resistance [0.03%]
宿主防御肽在避免抗菌素耐药性方面的结构洞见、免疫调节功能及治疗潜力
Gisele Regina Rodrigues,Michel Lopes Leite,Octavio Luiz Franco
Gisele Regina Rodrigues
Antimicrobial resistance (AMR) undermines the effectiveness of antibiotic treatment, and due to this, it now worldwide health concern. In general, antibiotics are used to control or combat bacteria, their widespread and irresponsible has co...
Bacteriophage endolysins: A promising therapeutic strategy against drug- resistant Staphylococcus aureus [0.03%]
细菌溶菌酶：治疗耐甲氧西林金黄色葡萄球菌感染的潜在方法
Niranjana Rajesh,Jaya Bisht,Thulasi Sunilkumar et al.
Niranjana Rajesh et al.
Staphylococcus aureus infections are difficult to treat due to the widespread emergence of antibiotic resistant strains, complex virulence mechanisms, and the ability to form recalcitrant biofilms. Infections with multi-drug resistant varia...
Takhellambam Malemnganba,Kirti Baghel,Sanjana Mehrotra et al.
Takhellambam Malemnganba et al.
The rapid rise of antibiotic-resistant bacteria has become a major clinical challenge, creating an urgent need for alternative therapeutic strategies. Antimicrobial peptides (AMPs) have emerged as promising candidates in the fight against t...