comBO: A combined human bone and lympho-myeloid bone marrow organoid for preclinical modeling of hematopoietic disorders [0.03%]
一种结合了人类骨骼和淋巴-骨髓组织的人造器官模型，用于血液系统疾病的临床前建模
Yuqi Shen,Camelia Benlabiod,Edmund Watson et al.
Yuqi Shen et al.
The bone marrow is the primary site of blood and immune cell production in postnatal life. Current human models do not capture lympho-myeloid hematopoiesis and the stromal diversity needed for lifelong blood and immune maintenance. Here, we...
VIPR1 acts as an enteric neural checkpoint that suppresses intestinal stem cell-driven epithelial regeneration and exacerbates colitis [0.03%]
VIPR1充当肠神经检查点以抑制肠道干细胞驱动的上皮再生并加重结肠炎
Chaoliang Li,Haohao Wang,Panrui Zhang et al.
Chaoliang Li et al.
Intestinal stem cells (ISCs) drive epithelial renewal and regeneration, yet how neural cues shape ISC behavior remains unclear. Here, we identify a neuronal checkpoint that directly restrains ISC regenerative output during injury. We show t...
Distinct spatial patterning and transcriptomic landscapes of human neural organoids by localized delivery of morphogens [0.03%]
形态发生素局部递送形成人类神经器官的特异性空间分布和转录组景观
Feiyu Yang,Narciso Pavon,Tatsuya Matsubara et al.
Feiyu Yang et al.
Positional patterning during human brain development is orchestrated through highly coordinated interplays of locally produced inductive signals. Although animal models have elucidated general signaling pathways during early neurodevelopmen...
Prevention of transgene silencing during human pluripotent stem cell differentiation [0.03%]
人类多能干细胞分化过程中防止转基因沉默
Takeshi Uenaka,Alan Napole,Aninda Dibya Saha et al.
Takeshi Uenaka et al.
Transgenes are often silenced upon differentiation of pluripotent stem cells using conventional expression systems. Here, we developed the TK4 PiggyBac vector to conduct a comparative analysis to evaluate the impact of various promoters, tr...
Engineered intestinal crypt geometry uncovers YAP1-dependent fetal-to-adult transition [0.03%]
工程化肠隐窝几何结构揭示YAP1依赖的胎儿至成人转换机制
Martti Maimets,Mikhail Nikolaev,Cecilia Lövkvist et al.
Martti Maimets et al.
During morphogenesis, the intestine undergoes significant structural remodeling, transitioning from a simple tube of immature epithelium into a complex crypt-villus architecture housing mature cell types. However, the relationship between t...
Chromatin Accessibility Dynamics during Chemical Induction of Pluripotency [0.03%]
化学诱导多能性过程中染色质可及性的动态变化
Shangtao Cao,Shengyong Yu,Dongwei Li et al.
Shangtao Cao et al.
Published Erratum
Cell stem cell. 2026 Feb 5:S1934-5909(26)00034-2. DOI:10.1016/j.stem.2026.01.011 2026
Sleep disturbance triggers aberrant activation of vagus circuitry and induces intestinal stem cell dysfunction [0.03%]
睡眠障碍会引发迷走神经回路异常激活并诱导肠道干细胞功能失调
Mingxin Zhang,Xi Wu,Di Liu et al.
Mingxin Zhang et al.
Sleep disturbances are associated with pathogenesis of numerous chronic disorders, including chronic gastrointestinal diseases. However, the mechanism that transmits sleep disturbance-induced aberrant neural signaling from the brain to the ...
Nurturing eggs with hiPSC-derived cells to improve outcomes in in vitro fertilization [0.03%]
利用诱导多能干细胞衍生细胞培育卵泡以改善体外受精结果
Fang Fang,Renee A Reijo Pera
Fang Fang
Clinical success of in vitro maturation (IVM) for fertility treatment is currently limited by the lack of a reliable source of ovarian support cells (OSCs) to nurture oocytes. Kramme et al. develop "Fertilo," a scalable, clinical-grade hiPS...
Editing the skin in place: In vivo genome correction of rare skin disease [0.03%]
就地编辑皮肤：罕见皮肤病的体内基因组纠正
Rohan Palanki,Emily Fitzgerald,Alexandre J Poirier et al.
Rohan Palanki et al.
In this issue, Apaydin and Sadhnani et al. report in situ genome editing of human skin to correct a common disease-causing mutation underlying autosomal recessive congenital ichthyosis (ARCI).1 They combine a base editor, transient barrier ...
Giulia Schiroli,Pietro Genovese
Giulia Schiroli
Midena et al.1 employ a nanoengineered 3D "nichoid" substrate that mechanically supports CD34+ hematopoietic stem and progenitor cells (HSPCs) during ex vivo manipulation, reducing culture-associated stress and improving engraftment and pol...