Modeling human prenatal adrenocortical functional zonation dynamics from pluripotent stem cells [0.03%]
从多能干细胞模拟人类胎盘肾上腺皮质功能带动力学分区模型
Michinori Mayama,Eoin C Whelan,Takeshi Sato et al.
Michinori Mayama et al.
The adrenal cortex produces essential steroid hormones through a concentric zonal architecture, established by the centripetal transdifferentiation of subcapsular progenitors within a capsule-derived niche. To capture this complexity, we es...
Birte Doludda,Warsha Barde,Francesco D&#x;Egidio et al.
Birte Doludda et al.
The 38 currently registered clinical trials with the keyword "adult neurogenesis" indicate growing interest in new neurons as a target for intervention. Today, we have strong evidence that adult neurogenesis is involved in hippocampal funct...
Two decades of induced pluripotent stem cell research: From discovery to diverse applications [0.03%]
诱导多能干细胞研究二十年：从发现到广泛应用
Shinya Yamanaka
Shinya Yamanaka
Twenty years have passed since the first demonstration of mouse induced pluripotent stem cells (iPSCs). What began as an unexpected observation in Kyoto quickly transformed stem cell biology and regenerative medicine worldwide. Over the pas...
Scott H Waddell,Luke Boulter
Scott H Waddell
In their recent Nature paper, Yuan et al. reconstruct patient-specific periportal architecture by assembling hepatocyte organoids with cholangiocytes and portal mesenchyme. Unlike previous attempts, these multicellular units recapitulate mu...
Off-the-shelf CAR natural killer progenitor cell therapies are built to last [0.03%]
即用型CAR天然杀伤细胞前体疗法可长期发挥作用
Noor Radde,Max Jan
Noor Radde
Induced pluripotent stem cell (iPSC)-derived chimeric antigen receptor (CAR) natural killer (NK) cells are an emerging class of off-the-shelf cellular immunotherapy limited by short-term persistence. Wang et al.1 develop a platform for line...
Cradles for maturation: Turning progenitor cells into functional intestinal epithelium [0.03%]
成熟的摇篮：将前体细胞转化为功能性的肠上皮细胞
Kaustav Bera,Kristi S Anseth
Kaustav Bera
Maimets et al.1 reveal that appropriate tissue shape is required during maturation of the intestinal epithelium from the fetal to adult state, and this transition is mediated by the mechanotransduction protein-YAP. The introduced method tra...
Neuronal VIP shapes intestinal stem cell activity and mucosal immunity [0.03%]
神经元VIP塑形肠干细胞活性及粘膜免疫反应
Camilla Anastasio,Lucie Peduto
Camilla Anastasio
Intestinal homeostasis and regeneration rely on intestinal stem cells (ISCs). Li et al.1 identified neuronal vasoactive intestinal peptide (VIP) as a brake on ISCs through VIPR1 to limit regeneration. In Nature Immunology, Jakob et al. and ...
Randomized phase 2b dose-escalation trial of stem cell therapy with laromestrocel for aging frailty [0.03%]
老年人衰弱细胞疗法laromestrocel随机IIb期爬坡剂量试验
Jorge G Ruiz,Anthony A Oliva Jr,Kevin N Ramdas et al.
Jorge G Ruiz et al.
Frailty, a syndrome that decreases healthspan in older individuals, lacks effective therapies. We conducted a randomized, dose-finding clinical trial to test whether human bone marrow-derived allogeneic mesenchymal stem cells (MSCs; laromes...
Pluripotent stem cell-derived CAR-NK progenitor therapy targets minimal residual disease and prevents relapse in leukemia models [0.03%]
人多能干细胞来源的CAR-NK祖细胞疗法可靶向白血病模型中的微量残余病并预防复发
Zhiqian Wang,Leqiang Zhang,Dehao Huang et al.
Zhiqian Wang et al.
Reducing relapse rates post-chemotherapy remains a major challenge for improving cancer therapy. Here, we developed a pluripotent stem cell-derived induced natural killer (NK) lineage-committed progenitor (iNKP) cell therapy in leukemia mod...
Minimizing far-extending chromatin perturbation in genome editing preserves stem cell identity [0.03%]
基因组编辑最小化染色质扰动以保持干细胞身份
Ming Zhu,Junsong Yuan,Qiuchen Meng et al.
Ming Zhu et al.
Although CRISPR-Cas9 holds therapeutic promise, broader application demands an understanding of complications in vast non-coding regions. We found that CRISPR-Cas9 can cause premature differentiation of neural stem cells in vivo and mouse e...