TCA cycle rewiring underpins histone acetylation sourcing and cell-fate transitions during exit from naive pluripotency [0.03%]
富集组蛋白乙酰化来源的三羧酸循环重编排促进全胚体诱导中的细胞命运转变
Eleni Kafkia,David Pladevall-Morera,Lidia Argemi-Muntadas et al.
Eleni Kafkia et al.
Metabolism shapes stem cell differentiation and epigenome regulation, especially during the exit from naive pluripotency in vitro. Yet how metabolic networks reorganize at implantation remains unclear. Here, we map metabolite routing in pre...
MMRN1-EGFR drives sialylglycan-Siglec immune evasion in AML leukemia stem cells [0.03%]
MMRN1-EGFR在急性髓系白血病干细胞中驱动岩藻糖基化糖类-Siglec免疫逃逸路径
Meixi Peng,Yongxiu Huang,Mengyun Zhang et al.
Meixi Peng et al.
Leukemia stem cells (LSCs) drive acute myeloid leukemia (AML) relapse and therapy resistance, predominantly through immune evasion. Here, we identify multimerin 1 (MMRN1) as being highly and specifically expressed in LSCs. Mechanistically, ...
Pre-adaptation of stem cell-derived islet organoids to hypoxia via zinc transportation inhibition drives angiogenesis [0.03%]
通过抑制干细胞衍生的胰岛类器官的锌转运来预先适应低氧诱导血管生成
Zhaoyue Wang,Minglu Xu,Rui Hu et al.
Zhaoyue Wang et al.
The clinical application of human stem cell-derived islet organoids (SC-islets) is hindered by immaturity and ischemia-induced dysfunction post-transplantation. Hypoxia-driven angiogenesis is a common adaptation, but the metabolic fragility...
Reconstructing tumor tissues in 3D: From organoids to bioengineered niches [0.03%]
从类器官到生物工程生态位：三维重建肿瘤组织
Verena J Kast,Fatemeh Navaee,Majid Halvaei et al.
Verena J Kast et al.
Tumor tissue engineering, integrating organoid, microfluidic, and biofabrication technologies, has opened new avenues for cancer research. Leveraging advanced bioengineering and biomaterials, these 3D models capture tumor architecture, cell...
Joanne I Hsu,Benjamin L Ebert
Joanne I Hsu
Detoxification of endogenous aldehydes is critical for preserving genomic integrity in hematopoietic stem cells. In this issue, Kamimae-Lanning et al.1 show that excess formaldehyde can drive clonal hematopoiesis through attrition of blood-...
Zheng-Kai Lao,Nan-Jie Xu
Zheng-Kai Lao
Hearing loss has been considered one of the key risk factors for cognitive decline and dementia. Liu et al.1 establish a causal link between hearing activity, hippocampal neurogenesis, and cognitive function and identify the locus coeruleus...
Turning drivers into regulators: In vivo CAR reprogramming of Tfh cells [0.03%]
将驾驶员细胞重编程为调节者细胞：Tfh细胞的体内CAR重组
Urmi Hofland,Maria Montes De Oca Arena,Laurence Morel
Urmi Hofland
Autoimmune hepatitis (AIH) is a progressive, life-threatening liver disease that remains treated largely with broad immunosuppression. In this issue of Cell Stem Cell, Jing and colleagues reprogram follicular helper T (Tfh) cells in vivo in...
Less is more: Reducing zinc to boost stem cell-derived islet function and survival [0.03%]
减少锌以增强干细胞衍生胰岛功能和存活量效关系的研究
Hazem Ibrahim,Diego Balboa,Timo Otonkoski
Hazem Ibrahim
Zinc is required for insulin packaging into secretory granules, yet reduced zinc transporter activity paradoxically enhances beta cell function. In this issue, Wang et al.1 show that pharmacologic inhibition of zinc transport in stem cell-d...
Haofei Wang,Li Qian
Haofei Wang
Directing the differentiation of human pluripotent stem cells into atrioventricular node-like cells is a critical strategy for restoring atrioventricular node dysfunction in patients. In this issue, Lohbihler et al. define a BMP2-driven pro...
Perturb-seq uncovers pathological obstacles to direct cardiac reprogramming in vivo [0.03%]
Perturb-seq发现体内直接心臟重新编程的病理障碍
Yihong Cai,Yang Yang,Junbo Yang et al.
Yihong Cai et al.
Direct induction of cardiomyocytes from fibroblasts represents a promising strategy for cardiac regeneration. However, the transdifferentiation efficiency in vivo remains low. Leveraging a Perturb-seq platform tailored to complex pathologic...