Zhen Sun,Ludi Zhang,Lijian Hui
Zhen Sun
Hepatocyte-based therapies represent a promising alternative to liver transplantation, yet their clinical translation is constrained by the limited availability of functional cells and inefficient engraftment. Here, we review progress in th...
Se-In Lee,Wenjie Luo,Li Gan
Se-In Lee
In a recent study in Science, Chen et al. engineer astrocytes with anti-amyloid chimeric antigen receptors (CARs) to enable sustained, antigen-directed clearance of amyloid-β (Aβ) in vivo, revealing how CAR design can shape both pathology...
Tracking time and space: A new integrative approach in spatiotemporal transcriptomics [0.03%]
时空追踪：时空转录组学的新整合方法
Suijuan Zhong,Qian Wu,Xiaoqun Wang
Suijuan Zhong
Niu et al.1 introduce SPTEdU-seq, a strategy that integrates spatial transcriptomics with EdU-based temporal labeling to jointly capture transcriptional states and proliferative history. This approach provides a framework for resolving spat...
Elisa T Zhang
Elisa T Zhang
Menstruation entails repeated cycles of cyclical shedding and scarless regeneration of the endometrium, yet the precise cellular states underlying this process have remained poorly defined. In this issue, Nikolakopoulou et al. establish an ...
eIF4G2-mediated selective translation of chromatin regulators safeguards adult intestinal stem cell identity and differentiation [0.03%]
EIF4G2介导的染色质调节因子选择性翻译保护肠道干细胞身份和分化
Haruko Kunitomi,Aye Myat Khaine,Radia Jamee et al.
Haruko Kunitomi et al.
eIF4G2 (DAP5/NAT1) is a non-canonical translation initiation factor, but its role in homeostasis is unclear. Using inducible Eif4g2 knockout mice and intestinal organoids, we show that eIF4G2 loss collapses Lgr5+ intestinal stem cell (ISC) ...
Embryonic MGE Precursor Cells Grafted into Adult Rat Striatum Integrate and Ameliorate Motor Symptoms in 6-OHDA-Lesioned Rats [0.03%]
胚胎MGE前体细胞移植物在成年脑内整合并改善6-OHDA损毁大鼠的运动症状
Verónica Martínez-Cerdeño,Stephen C Noctor,Ana Espinosa et al.
Verónica Martínez-Cerdeño et al.
Published Erratum
Cell stem cell. 2026 Apr 28:S1934-5909(26)00151-7. DOI:10.1016/j.stem.2026.04.011 2026
An in vitro menstrual cycle using organoids captures epithelial cell transitions during menstruation and regeneration of the human endometrium [0.03%]
一种体外月经周期模型使用类器官捕捉人类子宫内膜上皮细胞在月经期间的过渡及再生现象
Konstantina Nikolakopoulou,Weand Ybañez,Lhéanna Klaeylé et al.
Konstantina Nikolakopoulou et al.
Menstruation is an unusual process in which the human endometrium undergoes cyclical shedding with scarless regeneration. Despite its pivotal role in reproductive health, the cellular states and interactions orchestrating this process remai...
Engineered CAR-monocytes coordinate fibrosis clearance and cardiac regeneration following myocardial infarction [0.03%]
基因工程CAR-单核细胞在心肌梗死后协调纤维化清除和心脏再生
Zhenguo Wu,Xiaohan Zou,Chen Chen et al.
Zhenguo Wu et al.
Overwhelming cardiomyocyte death and excessive cardiac fibrosis post myocardial infarction (MI) collectively lead to heart failure and mortality. For treating this devastating disease, it is essential to eliminate fibrosis and reconstitute ...
Transcriptional profiles of immature neurons in aged human hippocampus track Alzheimer's pathology and cognitive resilience [0.03%]
衰老人类海马区未成熟神经元的转录组谱系追踪阿尔茨海默病病理和认知韧性
Giorgia Tosoni,Dilara Ayyildiz,Sarah Snoeck et al.
Giorgia Tosoni et al.
The existence and functional significance of immature neurons in the adult human brain, particularly in the context of neurodegenerative disorders, remain an open question. Although rodent studies have highlighted active roles for adult-bor...