Smooth muscle cells transiently acquire a CD34+ progenitor state upon injury to drive pathological vascular remodeling [0.03%]
损伤后平滑肌细胞会暂时获得一种CD34+干细胞状态以促进血管重塑
Yunrui Lu,Hui Ni,Jian Shen et al.
Yunrui Lu et al.
Neointimal hyperplasia, a key pathological feature of many cardiovascular diseases, is driven by vascular smooth muscle cells (SMCs), yet the role of specific SMC subtypes remains unclear. This study identifies a smooth muscle-derived trans...
Autologous macrophage therapy increases transplant-free survival in cirrhosis: Long-term follow-up of a phase 2 clinical trial [0.03%]
自身巨噬细胞治疗提高肝硬化的无移植生存率：一项二期临床试验的长期随访结果
Paul N Brennan,Alastair M Kilpatrick,Alison Glover et al.
Paul N Brennan et al.
Liver cirrhosis is a major contributor to global morbidity and mortality, and transplantation remains the only cure for end-stage disease. Preclinical studies have indicated that macrophage injections reduce inflammation, resolve fibrosis, ...
Human amygdala-like telencephalic organoids model stress circuitry in assembloid systems [0.03%]
人类似杏仁体的大脑皮层类器官在组装体系统中模拟应激环路
Woo Sub Yang,Mu Seog Choe,Cynthia Lo et al.
Woo Sub Yang et al.
Human emotional and stress responses are orchestrated by subcortical limbic circuits, with the amygdala playing a central role in integrating affective, sensory, and endocrine signals. Despite the urgent need to understand how these circuit...
Human retinal organoids functionally bridge a transected optic nerve in a rat model [0.03%]
人视网膜器官嵌合体在大鼠视神经横断模型中发挥功能连接作用
Yu Gong,Huiyu Zhu,Lingling Ge et al.
Yu Gong et al.
Functional restoration of vision in adult mammals remains unattainable following complete transection of the optic nerve. In this study, we address this challenge by heterotopically transplanting human retinal organoids into the transection...
Ferroptosis susceptibility in hippocampal neural precursor cells influences neurogenesis and memory across aging [0.03%]
海马神经前体细胞的铁死亡敏感性影响衰老过程中的神经发生和记忆能力
Zhenyu Zhang,Alison K Carlisle,Hamish P Carter et al.
Zhenyu Zhang et al.
Adult hippocampal neurogenesis declines with age, but the stress pathways that shape neural precursor cell (NPC) survival and lineage progression remain incompletely understood. Here, we tested whether ferroptosis-related vulnerability cont...
A precision product framework for context-dependent mechanisms of MSC therapy [0.03%]
一种精确的产品框架：MSC疗法依赖于上下文的机制
Donald G Phinney
Donald G Phinney
Despite decades of research, mesenchymal stem/stromal cell (MSC) therapy development has fallen short of expectations. Although regulatory convention prioritizes viability-centric metrics as proxies for potency, emerging evidence indicates ...
Human PSC-derived sinoatrial node-cardiac plexus assembloids model innervation-associated maturation of pacemaker systems [0.03%]
人PSC来源的窦房结-心脏plexus组装体模型起搏器系统的神经支配相关成熟过程
Tongdong Zhang,Lei Fan,Feibai Yao et al.
Tongdong Zhang et al.
Heart rhythm and contraction are initiated by electrical impulses generated by the sinoatrial node (SAN) and modulated by intrinsic cardiac neural inputs. Despite its physiological importance, human in vitro systems that recapitulate neural...
Genotoxicity profiling reveals distinct platform-and cell type-specific effects in therapeutic gene editing for genetic hyperinflammation [0.03%]
基因毒性谱分析揭示了遗传性高炎症治疗性基因编辑的平台和细胞类型特异性效应
Lei Lei,Masako M Kaufmann,Jessica Lao et al.
Lei Lei et al.
Base editors enable precise correction of point mutations without requiring DNA double-strand breaks, yet platform- and cell type-specific genotoxicities remain incompletely characterized. Here, we applied cytosine base editing (CBE) to dis...
A ketogenesis-ferroptosis axis maintains leukemic stem cell survival and leukemia progression [0.03%]
酮体生成-铁死亡轴维持白血病干细胞的存活和白血病的发展
Xue Han,Kexin Wang,Weiwei Ma et al.
Xue Han et al.
Hepatic ketogenesis generates ketone bodies as an alternative energy source during carbohydrate restriction or ketogenic diets, yet its role in non-hepatic cell types remains poorly defined. Here, we show that leukemic stem cells (LSCs) in ...
Leukemic stem cell subtypes determine venetoclax resistance and therapeutic vulnerabilities in AML [0.03%]
白血病干细胞亚群决定了AML中维奈托克的耐药性及治疗弱点
Alexander Waclawiczek,Aino-Maija Leppä,Simon Renders et al.
Alexander Waclawiczek et al.
The BCL-2 inhibitor venetoclax has transformed the treatment of acute myeloid leukemia (AML), but relapse due to resistance of leukemic stem cells (LSCs) remains a major challenge. By molecular and functional profiling of LSCs from >150 pat...