ENPP1 blockade with a humanized monoclonal antibody enhances renal repair after acute kidney injury [0.03%]
人源化单克隆抗体阻断ENPP1可在急性肾损伤后促进肾脏修复
Lianjiu Su,Qihao Sun,Ziheng Zhou et al.
Lianjiu Su et al.
The kidney possesses a poor ability to robustly regenerate and repair after acute injury. We show that the ectonucleotidase ENPP1 (ectonucleotide pyrophosphatase/phosphodiesterase-1) is robustly expressed in diseased human kidneys and stron...
ZNF512B safeguards genome integrity at regulatory regions to repress the SASP and inflammation [0.03%]
锌指蛋白512B通过调控区域保护基因组完整性以抑制衰老相关分泌表型和炎症反应
Sanjeeb Kumar Sahu,Sebastian Memczak,Sudhir Thakurela et al.
Sanjeeb Kumar Sahu et al.
Cellular senescence drives aging and disease largely through the senescence-associated secretory phenotype (SASP), yet its regulatory mechanisms remain unclear. Using a SASP reporter combined with a CRISPR-Cas9 screen targeting active regul...
SPACE-seq integrates spatial transcriptomics and lineage tracing in native tissues [0.03%]
SPACE-seq使空间转录组学和谱系示踪在天然组织中融为一体
Yuemeng Jia,Dawei Sun,Jackson A Weir et al.
Yuemeng Jia et al.
Understanding how cells change state, interact with their neighbors, and organize into tissues requires recording of cellular lineage history in native spatial context. Here, we present SPACE-seq (spatial tracing enabled by CRISPR-based bar...
Jonathan A Brassard,James M Wells
Jonathan A Brassard
Principles of developmental biology have inspired efforts for directed differentiation of human pluripotent stem cells (hPSCs), leading to the first generation of organoids that are now well established as models of human development and di...
Generation of human appetite-regulating neurons and tanycytes from pluripotent stem cells [0.03%]
人多能干细胞向食欲调节神经元和致密颗粒细胞的分化生成
Zehra Abay-Nørgaard,Anika K Mueller,Erno Hänninen et al.
Zehra Abay-Nørgaard et al.
The arcuate nucleus (ARC) and ventromedial hypothalamus (VMH) are highly specialized hypothalamic nuclei controlling appetite and energy expenditure. Here, we demonstrate that human VMH and ARC neurons can be generated from pluripotent stem...
Dominique D Bailey,Jianwen Que
Dominique D Bailey
In a recent Nature Biotechnology paper, Pablo De Coppi et al. integrate tissue engineering with organ transplantation in a porcine model. They demonstrate that microinjection of autologous myogenic precursors and fibroblasts into a decellul...
Ketone bodies as guardians of leukemic stemness through ferroptosis suppression [0.03%]
酮体通过抑制铁死亡来守护白血病干细胞属性
Xi Zhao,Li Zhuang,Boyi Gan
Xi Zhao
Leukemia stem cells exploit cell-intrinsic ketogenesis to suppress ferroptosis and sustain disease propagation. In this issue, Han et al.1 uncover a β-hydroxybutyrate-epigenetic-lipid remodeling axis that protects stemness by restraining f...
Beyond replacement: Immature neurons as resilience partners in the aging hippocampus [0.03%]
超越替代：不成熟的神经元作为抵抗衰老海马体损伤的伙伴
W Todd Farmer,Juan Song
W Todd Farmer
Whether new neurons contribute to human cognition in old age remains debated. Recently in Cell Stem Cell, Tosoni et al.1 show that immature-neuron transcriptional programs persist in the aged dentate gyrus and that their molecular state, no...
Human adrenal cortex organoids unlock new frontiers in development, disease, and regenerative therapy [0.03%]
人胎盘皮质类器官解锁发育、疾病和再生治疗的新领域
Pierre Val
Pierre Val
Recent studies by Mayama et al.1 and Akkerman et al.2 established human adrenal cortex organoids that recapitulate fetal and adult adrenal development, offering unprecedented insight into differentiation pathways and allowing disease modeli...
Evolving strategies for lineage tracing: Genetic markers, synthetic barcodes, and natural variants [0.03%]
谱系示踪策略的演变：基因标记物、合成条形码和天然变异体
Zhixin Kang,Hui Chen,Siyang Li et al.
Zhixin Kang et al.
Elucidating cell fate decision-making requires linking lineage history to dynamic phenotypic states. Driven by single-cell sequencing and genome engineering, lineage tracing has evolved from observational studies into a multidimensional, hi...