Human Pluripotent Stem Cell-Derived Neural Cells and Brain Organoids Reveal SARS-CoV-2 Neurotropism Predominates in Choroid Plexus Epithelium [0.03%]
人多能干细胞衍生的神经细胞和脑类器官表明SARS-CoV-2的嗜神经性在脉络膜上皮中占优势
Fadi Jacob,Sarshan R Pather,Wei-Kai Huang et al.
Fadi Jacob et al.
Neurological complications are common in patients with COVID-19. Although severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causal pathogen of COVID-19, has been detected in some patient brains, its ability to infect brain c...
Elaine Fuchs,Helen M Blau
Elaine Fuchs
Stem cells (SCs) maintain tissue homeostasis and repair wounds. Despite marked variation in tissue architecture and regenerative demands, SCs often follow similar paradigms in communicating with their microenvironmental "niche" to transitio...
Shinya Yamanaka
Shinya Yamanaka
Human pluripotent stem cells such as embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) provide unprecedented opportunities for cell therapies against intractable diseases and injuries. Both ESCs and iPSCs are already be...
Balancing Expectations for Success in Stem Cell-Based Clinical Trials for Parkinson's Disease [0.03%]
基于干细胞的帕金森病临床试验的成功期望的平衡策略
Olle Lindvall
Olle Lindvall
Upcoming clinical trials assessing transplantation of stem cell-derived dopaminergic neurons into the striatum in patients with Parkinson's disease could generate groundbreaking results on neuronal replacement in the human brain. However, a...
The Roadmap to Approval under Japan's Two-Track Regulatory System: Comparing Six Regenerative Medical Products [0.03%]
日本两条轨道监管体系下的审批路径：六种再生医药产品的对比分析
Shunsuke Matsushita,Keisuke Tachibana,Tetsuya Kusakabe et al.
Shunsuke Matsushita et al.
The Japanese conditional and time-limited (CTL) approval framework, a tiered system for regenerative medical products, was initiated in 2014. Here, we compare the dossiers of six regenerative medical products with either direct full approva...
Ethical and Policy Considerations for Human Embryo and Stem Cell Research in China [0.03%]
中国人类胚胎与干细胞研究的伦理及政策考虑
Yao-Jin Peng,Xiaoru Huang,Qi Zhou
Yao-Jin Peng
China's stem cell research policies are based on a cultural understanding that grants special protection to human embryos but does not assign them equivalent moral or legal status as fully developed humans. We discuss ethical considerations...
Introductions to the Community: Early-Career Researchers in the Time of COVID-19 [0.03%]
社区介绍：COVID-19时期的青年研究人员
Jason Tchieu,Noelia Urbán,Alice Soragni et al.
Jason Tchieu et al.
COVID-19 has unfortunately halted lab work, conferences, and in-person networking, which is especially detrimental to researchers just starting their labs. Through social media and our reviewer networks, we met some early-career stem cell i...
Solving the Puzzle of Immune Tolerance for β-Cell Replacement Therapy for Type 1 Diabetes [0.03%]
解决1型糖尿病β细胞替代疗法免疫耐受难题
Jeffrey A Bluestone,Qizhi Tang
Jeffrey A Bluestone
Type 1 diabetes mellitus results from autoimmune destruction of pancreatic β cells. Insulin treatment is often inadequate in preventing devastating complications. Replacing β cells using stem cell-derived islets while fostering immune tol...
Hengli Tang
Hengli Tang
Among the common flaviviruses that infect humans, Zika virus, and the contemporary Asian strain in particular, is distinctively associated with microcephaly. Zeng et al. (2020) report in this issue of Cell Stem Cell that strong binding and ...
The Hippo Show Must Go On: YAP Activation as a Therapeutic Strategy in Colorectal Cancer [0.03%]
河马秀必须继续进行：YAP活化作为结直肠癌的治疗策略
Veronica Veschi,Giorgio Stassi
Veronica Veschi
The role of Hippo pathway in colorectal cancer (CRC) initiation and progression has been controversial. In this issue of Cell Stem Cell, Cheung et al. (2020) shed new light on a distinct function of the transcriptional co-activator YAP as a...