Yu-Ju Su,Jen-Chieh Lee
Yu-Ju Su
Phosphaturic mesenchymal tumor (PMT) is a rare bone or soft tissue tumor. It exhibits distinctive morphologic features, including bland spindled cells, highly vascularized stroma, "smudgy or grungy" calcified matrix, and osteoclast-like gia...
Ahmed Shah,Andrew L Folpe
Ahmed Shah
This article discusses very rare rhabdomyosarcomas of bone, in particular, those harboring FET::TFCP2 (EWSR1 or FUS::TFCP2) or MEIS1::NCOA2 fusions. The diagnosis of these tumors may be challenging, owing to their rarity, and requires integ...
Naohiro Makise,Akihiko Yoshida
Naohiro Makise
Undifferentiated small round cell sarcomas are a heterogeneous group of high-grade sarcomas of uncertain histogenesis. In this review, the key clinicopathological, immunohistochemical, and molecular characteristics of select entities that c...
Kelsey E McHugh,John D Reith,Scott E Kilpatrick
Kelsey E McHugh
Primary tumors of bone encompass a wide array of lineages of differentiation, including osteogenic, chondrogenic, fibrogenic, vascular, hematopoietic, and notochordal, amongst other mesenchymal lineages of origin. Osteogenic neoplasms of bo...
Osteosarcoma [0.03%]
骨肉瘤
John M Gross,Meera Hameed
John M Gross
The diagnosis of osteosarcoma can be challenging, given the diverse histologic patterns, limited biopsy samples, lack of tumor-specific molecular alterations, and necessity for radiologic correlation. This review summarizes the key patholog...
Cartilage Tumors [0.03%]
软骨肿瘤
Suk Wai Lam,Judith V M G Bovée
Suk Wai Lam
Cartilage tumors consist of a heterogeneous group of neoplasms characterized by the production of cartilage. Benign cartilage tumors generally exhibit slow growth and indolent behavior, while chondrosarcoma are more aggressive. Due to the o...
Julio A Diaz-Perez,Andrew E Rosenberg
Julio A Diaz-Perez
The tissues removed in the surgical treatment of nonneoplastic musculoskeletal diseases represent the most frequent source of surgical pathology specimens in bone and soft tissue pathology. The pathologic changes in these specimens are ofte...
Advances in Pediatric Pathology: Bridging Innovation and Clinical Practice for Emerging Entities [0.03%]
儿科病理学进展：新兴实体的创新与临床实践之间的桥梁
Alyaa Al-Ibraheemi
Alyaa Al-Ibraheemi
Molecular Diagnostics in Pediatric Pathology Practice: Current Trends and Development [0.03%]
分子诊断在儿科病理学实践中的现状和展望
Lea F Surrey,Alanna J Church,Nya D Nelson
Lea F Surrey
Molecular diagnostics are rapidly evolving to support the diagnosis, prognosis, and treatment of pediatric disease. This article summarizes the recent clinically relevant technology advances and their application to constitutional, mosaic, ...
Nakul Shankar,Portia A Kreiger,Derek A Oldridge et al.
Nakul Shankar et al.
Applications of artificial intelligence (AI) and machine learning (ML) are rapidly developing to support the diagnosis and classification of pathology specimens. These tools rely on digitization of pathology glass slides as whole slide imag...