Andrew Lingard,Sanja Dacic
Andrew Lingard
The identification of actionable genomic alterations in lung cancer represents the established standard of care, serving as the foundation for selecting the most efficacious therapies. As the scope of molecular and biomarker testing in lung...
Boju Pan,Dong Ren,Ghulam Rasool et al.
Boju Pan et al.
Soft-tissue tumors are rare mesenchymal neoplasms characterized by extensive morphologic and genetic heterogeneity. Advances in molecular pathology have transformed their diagnosis, classification, and therapeutic management. Recurrent geno...
Floriana Jessica Di Paola,Giulia Calafato,Kerry Jane Rhoden et al.
Floriana Jessica Di Paola et al.
Endocrine gland tumors are characterized by a wide spectrum of pathologic, clinical, and molecular features. Next-generation sequencing technologies have greatly improved our knowledge of this group of neoplasms, showing robust genotype-phe...
Gabriel C Caponetti,Adam Bagg
Gabriel C Caponetti
The understanding of the biologic basis of mature lymphoid neoplasms has been impacted through the sequential integration of emerging molecular technologies. Early techniques such as Southern blotting were foundational in establishing molec...
Hannah Goulart,Sanam Loghavi
Hannah Goulart
This article summarizes the contemporary diagnostic and prognostic frameworks for myeloid neoplasms, with a focus on myelodysplastic neoplasms/syndromes and acute myeloid leukemia. The authors focus on the updated classification systems per...
Molecular Pathology of Primary Central Nervous System Tumors: When and How Immunohistochemical Surrogates Inform Diagnosis [0.03%]
原发中枢神经系统肿瘤的分子病理学：免疫组化替代诊断的信息何时以及如何发挥作用
Mariëtte E G Kranendonk,Evert-Jan Kooi,Pieter Wesseling
Mariëtte E G Kranendonk
For a subset of tumors of the central nervous system (CNS), immunohistochemistry (IHC) allows for reaching a histomolecular diagnosis conform or close to the World Health Organization classification without the necessity of performing molec...
Mine M Yilmaz,Sidra Zaheer,Mahesh M Mansukhani et al.
Mine M Yilmaz et al.
In this article, the authors review the types of molecular alterations present in cancer and molecular methods used commonly in clinical diagnostic laboratories, including technologies such as next-generation sequencing and digital polymera...
Gloria Hopkins Sura
Gloria Hopkins Sura
This article highlights best practices in molecular pathology, emphasizing the impact of preanalytical variables on nucleic acid quality and test performance. It covers optimal specimen selection, handling, and preservation strategies for t...
Breast Papillary Neoplasms [0.03%]
乳头状乳腺肿瘤
Theodore Vougiouklakis,Edi Brogi
Theodore Vougiouklakis
Breast papillary neoplasms are a heterogeneous group of proliferative epithelial lesions. Although precise classification can be challenging at times, application of established diagnostic criteria, often combined with immunohistochemical m...
Eleanor Russell-Goldman
Eleanor Russell-Goldman