Diagnostic Significance and Reproducibility of Non-conventional Dysplasia and Serrated Epithelial Change in Inflammatory Bowel Disease [0.03%]
炎症性肠病中非典型发育不良和息肉样上皮改变的诊断意义及可重复性研究
Won-Tak Choi,Gregory Y Lauwers
Won-Tak Choi
Although most dysplastic lesions in inflammatory bowel disease resemble sporadic adenomas, several distinct morphologic patterns, collectively termed non-conventional dysplasia, have recently been described. Accurate evaluation of these les...
Complete versus Incomplete Gastric Intestinal Metaplasia: Unpacking the Role and Ongoing Controversy from the Perspective of the Gastrointestinal Pathologist [0.03%]
完整型与不完全型胃肠上皮化生：胃肠病理学家视角下的作用及持续争议解析
Osman Yilmaz,Vikram Deshpande
Osman Yilmaz
Intestinal metaplasia (IM), a precancerous precursor lesion to gastric cancer, can be subtyped as complete or incomplete, with the latter associated with a higher cancer risk. This article provides an in-depth evaluation of gross/endoscopic...
Ancillary Studies in the Diagnosis and Classification of Barrett Esophagus: What's on the Menu? [0.03%]
巴雷特食管诊断和分类的辅助研究：有哪些选择？
Danielle A Hutchings,Elizabeth A Montgomery
Danielle A Hutchings
Barrett's esophagus confers an increased risk for esophageal adenocarcinoma. Accurate detection and risk stratification of patients with Barrett's esophagus presents certain challenges. Current paradigms rely on endoscopic examination and h...
Sinchita Roy-Chowdhuri
Sinchita Roy-Chowdhuri
Francesco Pepe,Alessandro Russo,Gianluca Russo et al.
Francesco Pepe et al.
In the era of precision medicine, the growing number of predictive biomarkers have modified the clinical paradigm for advanced tumor patients. Standard tissue specimens are often limited for comprehensive genomic profiling for testing bioma...
Amir Momeni-Boroujeni,Rajmohan Murali
Amir Momeni-Boroujeni
This article summarizes the molecular landscape of epithelial and non-epithelial ovarian tumors, integrating current genomic and immunophenotypic data. High-grade serous carcinomas are defined by TP53 and homologous recombination defects, w...
Amanda L Strickland,Molly Parrish,Russell R Broaddus
Amanda L Strickland
Endometrial cancer is the most frequently occurring gynecologic malignancy in the Western world. It has previously been classified using histologic determinants, but more recent classifications have incorporated features of molecular pathol...
Molecular Pathology of Genitourinary Tumors: Diagnostic, Prognostic, and Therapeutic Implications [0.03%]
泌尿生殖系统肿瘤的分子病理学：诊断、预后和治疗意义
Alessia Cimadamore,Antonio Lopez-Beltran,Rodolfo Montironi et al.
Alessia Cimadamore et al.
Recent advances in molecular profiling, including next-generation sequencing and bioinformatic approaches, have enabled detailed characterization of tumor biology and facilitated patient stratification based on prognostic and predictive fac...
Oncogenicity and Therapeutic Implications of Molecular Biomarkers in Colorectal Carcinoma [0.03%]
结直肠癌分子生物标志物的致癌作用及治疗意义
Mark G Evans,Jaclyn F Hechtman
Mark G Evans
Colorectal carcinoma (CRC) is the most prevalent malignancy of the gastrointestinal tract and remains a leading cause of cancer-related illness and death worldwide. Recently, new treatment strategies have emerged with the identification of ...
Twisted Tapestry of Tumors: Updates in Molecular Pathology of Breast Tumors [0.03%]
肿瘤扭曲的挂毯：乳腺肿瘤分子病理学的更新
Raza S Hoda,Hannah Y Wen
Raza S Hoda
This article explores the expanding role of molecular diagnostics in breast pathology. It emphasizes how immunohistochemistry, fluorescence in situ hybridization, and next-generation sequencing define tumor subtypes with recurrent genetic a...