Mesenchymal Neoplasms of the Bladder and Male Genital Tract, including the Perineum and Scrotum [0.03%]
包括会阴和阴囊的膀胱和男性生殖道间叶源性肿瘤
David J Papke Jr
David J Papke Jr
Mesenchymal neoplasms of the bladder and male genital tract are uncommonly encountered in routine diagnostic practice and present diagnostic challenges. Here, I systematically survey mesenchymal tumors at each body site, including the sperm...
David J Papke Jr
David J Papke Jr
Mesenchymal neoplasms of the kidney present challenges because they are uncommon, and because perinephric soft tissue biopsies are sometimes submitted as "kidney" masses, causing diagnostic confusion. Here, the author thoroughly reviews mes...
Claudia M Salgado,Catherine K Gestrich,Miguel Reyes-Múgica
Claudia M Salgado
Pediatric cancer is relatively rare compared to cancer in adults. Most pediatric neoplasms affect the hemopoietic and central nervous systems. Of the solid extracranial tumors, renal and genitourinary lesions are among the most frequent ped...
Tissue-Based Biomarkers Important for Prognostication and Management of Genitourinary Tumors, Including Surrogate Markers of Genomic Alterations [0.03%]
基于组织的生物标志物在生殖泌尿系统肿瘤预后和管理中的重要作用，包括基因组改变替代标志物
Leonie Beauchamp,Shreeya Indulkar,Eric Erak et al.
Leonie Beauchamp et al.
A better understanding of the molecular alterations that underlie urologic malignancies and advances in targeted therapies has impacted classification, prognostication, and treatment. In bladder tumors, these advances include the developmen...
Sounak Gupta,John C Cheville
Sounak Gupta
Herein, the authors have discussed a series of uncommon familial kidney cancer syndromes (including hyperparathyroidism-jaw tumor syndrome and PTEN hamartoma tumor syndrome), sporadically occurring tumors (BRAF and MTOR pathway-mutated tumo...
What Is New in Pathologic Diagnosis and Classification of the Common Renal Cell Neoplasms? [0.03%]
常见肾细胞肿瘤的病理诊断和分类的新进展是什么？
Nicole Zalles,Sean R Williamson
Nicole Zalles
Diagnostic challenges remain among the common renal cell carcinoma (RCC) subtypes. High-grade clear cell RCC may have deceptive patterns, for example BAP1-deficient tumors. Subtyping type 1 and 2 papillary RCC is no longer recommended, as f...
Molecular Pathology and Biomarkers of Penile Squamous Cell Carcinoma: Implications for Classification and Management [0.03%]
阴茎鳞状细胞癌的分子病理和生物标志物：分类和治疗的启示
Alcides Chaux,Sofia Canete-Portillo
Alcides Chaux
This review explores the current understanding and management of penile squamous cell carcinoma, emphasizing recent advances in molecular pathology and treatment strategies. The article discusses the importance of human papillomavirus statu...
Review of Paratesticular Appendageal Tumors, Morphology, Immunohistochemistry, and Recent Molecular Advances [0.03%]
附睾旁肿瘤的形态、免疫组化和最近分子进展综述
Mathew Vega,Muhammad T Idrees
Mathew Vega
Paratesticular tumors are a rare and varied group of neoplasms arising from the tissues surrounding the testis, including the epididymis, spermatic cord, and tunica vaginalis, representing less than 10% of intrascrotal tumors. Benign tumors...
Somatic-type Malignancies of Germ Cell Origin: Molecular, Pathologic, and Clinical Features [0.03%]
体细胞性生殖细胞肿瘤的分子、病理和临床特点
Stephanie E Siegmund,Andrés Martin Acosta
Stephanie E Siegmund
Somatic-type malignancies (STMs) arising in germ cell tumors are relatively rare, affecting 3% to 8% of patients. These neoplasms show aggressive clinical behavior and are frequently resistant to systemic therapy. In the current review, we ...
Molecular Landscape of Aggressive Histologic Subtypes of Localized Prostate Cancer [0.03%]
局部前列腺癌侵袭性组织学亚型的分子图谱
Chien-Kuang C Ding,Nancy Y Greenland,Deepika Sirohi et al.
Chien-Kuang C Ding et al.
Despite incredible progress in describing the molecular underpinnings of prostate cancer over the last decades, pathologic examination remains indispensable for predicting aggressive behavior in the localized setting. Beyond pathologic grad...