Microsatellite Instability, Mismatch Repair, and Tumor Mutation Burden in Lung Cancer [0.03%]
肺癌中的微卫星不稳定性、错配修复和肿瘤突变负荷
Oana C Rosca,Oana E Vele
Oana C Rosca
Since US Food and Drug Administration approval of programmed death ligand 1 (PD-L1) as the first companion diagnostic for immune checkpoint inhibitors (ICIs) in non-small cell lung cancer, many patients have experienced increased overall su...
Sanja Dacic
Sanja Dacic
Major pathologic response (MPR) and pathologic complete response (pCR) are increasingly being used in non-small cell lung carcinoma neoadjuvant clinical trials as an early endpoint of survival. MPR for all histologic types of lung cancer is...
Andre L Moreira,Fang Zhou
Andre L Moreira
Lung adenocarcinoma staging and grading were recently updated to reflect the link between histologic growth patterns and outcomes. The lepidic growth pattern is regarded as "in-situ," whereas all other patterns are regarded as invasive, tho...
Huihua Li,Aliya N Husain,David Moffat et al.
Huihua Li et al.
Spindle cell lesions of the pleura and pericardium are rare. Distinction from sarcomatoid mesothelioma, which has a range of morphologic patterns, can be difficult, but accurate diagnosis matters. This article provides practical guidance fo...
Ken-Ichi Yoshida,Akihiko Yoshida
Ken-Ichi Yoshida
Primary sarcoma of the lung and mediastinum is rare. The diagnosis requires careful exclusion of sarcomatoid carcinoma, sarcomatoid mesothelioma, and metastases from extra-thoracic sites. This review summarizes the key morphologic, immunohi...
Ridhi Sood,Deepali Jain
Ridhi Sood
Pulmonary salivary gland-type, although bear resemblance to their salivary gland counterparts, present a diagnostic challenge due to their rarity. Clinical features overlap with lung carcinoma; however, management strategies and outcomes ar...
Mary Beth Beasley
Mary Beth Beasley
Interstitial lung abnormalities (ILA) is a radiographic term, which has recently undergone clarification of definition with creation of 3 subtypes. ILA is defined as incidental identification of computed tomography abnormalities in a patien...
Alain C Borczuk
Alain C Borczuk
The pathology of severe COVID-19 lung injury is predominantly diffuse alveolar damage, with other reported patterns including acute fibrinous organizing pneumonia, organizing pneumonia, and bronchiolitis. Lung injury was caused by primary v...
Update on Silicosis [0.03%]
关于硅肺病的最新研究进展
Andrew Churg,Nestor L Muller
Andrew Churg
Although silicosis has been an established disease with a recognized cause for more than 100 years, many workers continue to be exposed to silica and new outbreaks of disease continue to occur. This article describes some of the well-establ...
Granulomatous Lung Diseases: A Practical Approach and Review of Common Entities [0.03%]
肉芽肿性肺病:常见疾病的实用方法和综述
Jackie Cheuk Ki Chan,Jennifer M Boland
Jackie Cheuk Ki Chan
Granulomas are frequently encountered by pathologists in all types of lung specimens and arise from diverse etiologies. They should always be reported as necrotizing or non-necrotizing, with microorganism stains performed to evaluate for in...