Sinchita Roy-Chowdhuri
Sinchita Roy-Chowdhuri
Francesco Pepe,Alessandro Russo,Gianluca Russo et al.
Francesco Pepe et al.
In the era of precision medicine, the growing number of predictive biomarkers have modified the clinical paradigm for advanced tumor patients. Standard tissue specimens are often limited for comprehensive genomic profiling for testing bioma...
Amir Momeni-Boroujeni,Rajmohan Murali
Amir Momeni-Boroujeni
This article summarizes the molecular landscape of epithelial and non-epithelial ovarian tumors, integrating current genomic and immunophenotypic data. High-grade serous carcinomas are defined by TP53 and homologous recombination defects, w...
Amanda L Strickland,Molly Parrish,Russell R Broaddus
Amanda L Strickland
Endometrial cancer is the most frequently occurring gynecologic malignancy in the Western world. It has previously been classified using histologic determinants, but more recent classifications have incorporated features of molecular pathol...
Molecular Pathology of Genitourinary Tumors: Diagnostic, Prognostic, and Therapeutic Implications [0.03%]
泌尿生殖系统肿瘤的分子病理学：诊断、预后和治疗意义
Alessia Cimadamore,Antonio Lopez-Beltran,Rodolfo Montironi et al.
Alessia Cimadamore et al.
Recent advances in molecular profiling, including next-generation sequencing and bioinformatic approaches, have enabled detailed characterization of tumor biology and facilitated patient stratification based on prognostic and predictive fac...
Oncogenicity and Therapeutic Implications of Molecular Biomarkers in Colorectal Carcinoma [0.03%]
结直肠癌分子生物标志物的致癌作用及治疗意义
Mark G Evans,Jaclyn F Hechtman
Mark G Evans
Colorectal carcinoma (CRC) is the most prevalent malignancy of the gastrointestinal tract and remains a leading cause of cancer-related illness and death worldwide. Recently, new treatment strategies have emerged with the identification of ...
Twisted Tapestry of Tumors: Updates in Molecular Pathology of Breast Tumors [0.03%]
肿瘤扭曲的挂毯：乳腺肿瘤分子病理学的更新
Raza S Hoda,Hannah Y Wen
Raza S Hoda
This article explores the expanding role of molecular diagnostics in breast pathology. It emphasizes how immunohistochemistry, fluorescence in situ hybridization, and next-generation sequencing define tumor subtypes with recurrent genetic a...
Andrew Lingard,Sanja Dacic
Andrew Lingard
The identification of actionable genomic alterations in lung cancer represents the established standard of care, serving as the foundation for selecting the most efficacious therapies. As the scope of molecular and biomarker testing in lung...
Boju Pan,Dong Ren,Ghulam Rasool et al.
Boju Pan et al.
Soft-tissue tumors are rare mesenchymal neoplasms characterized by extensive morphologic and genetic heterogeneity. Advances in molecular pathology have transformed their diagnosis, classification, and therapeutic management. Recurrent geno...
Floriana Jessica Di Paola,Giulia Calafato,Kerry Jane Rhoden et al.
Floriana Jessica Di Paola et al.
Endocrine gland tumors are characterized by a wide spectrum of pathologic, clinical, and molecular features. Next-generation sequencing technologies have greatly improved our knowledge of this group of neoplasms, showing robust genotype-phe...