Early Administration of Adjuvant β-Lactam Therapy in Combination with Vancomycin among Patients with Methicillin-Resistant Staphylococcus aureus Bloodstream Infection: A Retrospective, Multicenter Analysis [0.03%]
万古霉素联合β-内酰胺类药物早期辅助治疗甲氧西林耐药金黄色葡萄球菌血流感染：一项回顾性、多中心研究分析
Anthony M Casapao,David M Jacobs,Dana R Bowers et al.
Anthony M Casapao et al.
Study objective: To determine whether early administration of adjuvant β-lactam in combination with vancomycin (COMBO) affects clinical outcomes compared to standard vancomycin therapy alone (STAN) among patients with me...
Multicenter Study
Pharmacotherapy. 2017 Nov;37(11):1347-1356. DOI:10.1002/phar.2034 2017
The Effect of Morphine Dosing on Length of Stay in Neonatal Abstinence Syndrome - An Alternative Viewpoint [0.03%]
阿片类药物剂量对新生儿戒断综合征住院时间的影响——另一种观点
Kirsten H Ohler,Jennifer T Pham
Kirsten H Ohler
A Novel Use of Olaparib for the Treatment of Metastatic Castration-Recurrent Prostate Cancer [0.03%]
奥拉帕利治疗转移性去势抵抗性前列腺癌的一项新用途
Grace A Martin,Adrienne H Chen,Kinjal Parikh
Grace A Martin
Although mortality from prostate cancer has declined over the past 20 years as a result of early detection and treatment, the 5-year survival rate for men with prostate cancer who develop metastatic disease is only 29%. Current treatment op...
Opioid and Benzodiazepine Weaning in Pediatric Patients: Review of Current Literature [0.03%]
儿科患者阿片类和苯二氮卓类药物减量的现状及文献综述
Norman E Fenn rd,Kimberly S Plake
Norman E Fenn rd
Pediatric opioid and benzodiazepine withdrawal are avoidable complications of pain and sedation management that is well described in the literature. To prevent withdrawal from occurring, practitioners regularly use a steady decrease of pain...
Mojdeh S Heavner,Min Zhang,Chelsea E Bast et al.
Mojdeh S Heavner et al.
Pregnant women are at high risk for venous thromboembolism, including pulmonary embolism (PE), given expected changes in coagulation, fibrinolysis, and venous blood flow. In fact, PE is the leading cause of maternal death in the United Stat...
Lina Meng,Emily Mui,Marisa K Holubar et al.
Lina Meng et al.
Physiologic alterations seen in obesity commonly impact the pharmacokinetics (PK) and pharmacodynamics (PD) of antibiotics and may result in suboptimal dosing in this expanding but understudied population. Much of the published clinical and...
Intravenous-only or Intravenous Transitioned to Oral Antimicrobials for Enterobacteriaceae-Associated Bacteremic Urinary Tract Infection [0.03%]
肠杆菌血流感染性尿路感染的经验性抗菌治疗中静脉给药与序贯口服给药的效果比较研究
Krista L Rieger,John A Bosso,Shawn H MacVane et al.
Krista L Rieger et al.
Objectives: To characterize antibiotic regimens utilized for bacteremic Enterobacteriaceae urinary tract infections and assess treatment failure associated with intravenous-only compared to intravenous transitioned to ora...
Comparative Study
Pharmacotherapy. 2017 Nov;37(11):1479-1483. DOI:10.1002/phar.2024 2017
Persistence of Delirium after Cessation of Sedatives and Analgesics and Impact on Clinical Outcomes in Critically Ill Patients [0.03%]
危重症患者镇静镇痛药物停用后谵妄的持续性及其对预后的影响
Michael T Kenes,Joanna L Stollings,Li Wang et al.
Michael T Kenes et al.
Study objective: As delirium is a common manifestation in critically ill patients and is associated with worse clinical outcomes, we sought to characterize the reversibility of delirium after discontinuation of sedation a...
Comparison of Bioavailability of Single-Dose Extended-Release Venlafaxine Capsules in Obese Patients Before and After Gastric Bypass Surgery [0.03%]
肥胖患者术前术后单剂量施用盐酸文拉法辛缓释胶囊的生物利用度比较研究
Carrie A Krieger,Julie L Cunningham,Joel M Reid et al.
Carrie A Krieger et al.
Study objective: The extended-release (ER) form of venlafaxine is preferred because of improved patient adherence, but the immediate-release (IR) form is frequently used after Roux-en-Y gastric bypass (RYGB) surgery becau...
Controlled Clinical Trial
Pharmacotherapy. 2017 Nov;37(11):1374-1382. DOI:10.1002/phar.2022 2017
Jeffrey R Bishop,Vicki L Ellingrod
Jeffrey R Bishop